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Cited by 411Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and ManagementPancreatic function and diabetes

The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.

The effect of aging on carbohydrate metabolism: A review of the English literature and a practical approach to the diagnosis of diabetes mellitus in the elderly

Davidson, Mayer B.·1979·Metabolism
DOI 10.1016/0026-0495(79)90024-6
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Abstract

There seems little doubt that the disposal of a glucose load is progressively impaired during aging. The mechanism(s) for this alteration remains unclear. Five possibilities have been raised: (1) poor diet, (2) physical inactivity, (3) decreased lean body mass in which to store the carbohydrate load, (4) decreased insulin secretion, and (5) insulin antagonism. Although poor diet and physical inactivity may contribute to some of the abnormal glucose tolerance tests of the older population, these two factors do not provide a full explanation. Diminished lean body mass may play some role but there is almost certainly an additional effect due to aging. A few papers have suggested that glucose-induced insulin secretion may be impaired as the population ages, but the bulk of studies in this area conclude that normal or increased amounts of insulin are released by the pancreatic beta-cell during aging. If abnormalities of insulin secretion exist, either in degree or timing, they are subtle and would not seem sufficient to account for the great number of older subjects who manifest impaired glucose tolerance. The evidence for insulin antagonism seems the strongest but the data are certainly not conclusive. In actuality, the aging effect on carbohydrate metabolism may be heterogeneous in nature. Either some or all of these five factors may contribute to the aging effect to varying degrees in individual subjects. Alternatively, the glucose intolerance of aging may represent a heterogeneous group of disorders. In any event, until better methods to identify possible subgroups of these subjects and/or a marker for diabetes mellitus independent of glucose concentration become available, this problem will remain difficult to resolve. Based on the currently available data, it seems prudent to diagnose diabetes mellitus only if fasting hyperglycemia is present.

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Citations

Cites

Show all 195 references

Research works printed but not linked: 9

  1. Deren, 1936, Dextrose tolerance in the aged, J Lab Clin Med, 22, 1135
  2. Vinik, 1968, Hyperglycemia in the elderly—Is it diabetes?, Diabetes, 17, 348
  3. Nilsson, 1964, The Kristianstad survey, Acta Med Scand, 428, 1
  4. Langs, 1965, Responses in serum insulin concentration to the cortisone glucose tolerance test (CGTT): The importance of age, Diabetes, 15, 539
  5. Fajans, 1975, Heterogeneity of insulin responses inlatent diabetes, Trans Assoc Am Physicians, 87, 83
  6. Reaven, 1979, Decreased cell insulin response in aging rats, Clin Res, 27, 87
  7. Cushman, 1977, Dietary-induced alteration in insulin-stimulated glucose transport activity in rat adipose cells in the absence of altered insulin binding, Diabetologia, 13, 388
  8. Korkushko, 1972, Age peculiarities of the effect of glucagon on blood sugar level and oxygen consumption in apparently healthy persons, Probl Endokrinol, 18, 46
  9. Lubetzki, 1976, Its evolution in correlation with some clinical and biological features. Study in 94 subjects, Diabetologia, 12, 407

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Metadata

Authors
Davidson, M. B.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Davidson, Mayer B.
ORCID
Davidson, Mayer B.
Venue
Metabolism
Publisher
Elsevier BV
Published
1979-06
Volume
28
Issue
6
Pages
688-705
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(79)90024-6
OpenAlex
W2056966934
Cited by
411
References
195
Citations by year
2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 7 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 2 · 2013: 7 · 2012: 3
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords
aging, carbohydrate metabolism, impaired glucose tolerance, diabetes diagnosis, older adults, insulin secretion, insulin antagonism, lean body mass, physical inactivity, diet, fasting hyperglycemia
MeSH terms
Insulin Secretion, Aged, Blood Glucose, Diabetes Mellitus, Fasting, Fatty Acids, Nonesterified, Female, Fructose, Galactose, Glucose Tolerance Test, Humans, Insulin, Islets of Langerhans, Male, Tolbutamide, Carbohydrate Metabolism

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