The Endocrinology of Aging

Lamberts, Steven W. J.; van den Beld, Annewieke W.; van der Lely, Aart-Jan

doi:10.1126/science.278.5337.419

Cited by 980Hormonal and reproductive studiesMenopause: Health Impacts and TreatmentsGrowth Hormone and Insulin-like Growth Factors

The Endocrinology of Aging

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Lamberts, Steven W. J., van den Beld, Annewieke W., van der Lely, Aart-Jan·1997·Science

DOI 10.1126/science.278.5337.419

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Abstract

Most aging individuals die from atherosclerosis, cancer, or dementia; but in the oldest old, loss of muscle strength resulting in frailty is the limiting factor for an individual's chances of living an independent life until death. Three hormonal systems show decreasing circulating hormone concentrations during normal aging: (i) estrogen (in menopause) and testosterone (in andropause), (ii) dehydroepiandrosterone and its sulphate (in adrenopause), and (iii) the growth hormone/insulin-like growth factor I axis (in somatopause). Physical changes during aging have been considered physiologic, but there is evidence that some of these changes are related to this decline in hormonal activity. Hormone replacement strategies have been developed, but many of their aspects remain controversial, and increasing blood hormone levels in aging individuals to those found during mid-adult life has not been uniformly proven to be safe and of benefit.

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“this has led to the conclusion that age-related changes in the endocrine system contribute to declines in lymphopoiesis.”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [43]

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Authors: Lamberts, S. W. J., van den Beld, A. W., & van der Lely, A.-J.
Affiliations: Erasmus University Rotterdam (NL)
The authors are in the Department of Medicine, Erasmus University, Rotterdam, Netherlands.
Corresponding author: Lamberts, Steven W. J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-10-17
Volume: 278
Issue: 5337
Pages: 419-424
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.278.5337.419
OpenAlex: W1986568472
Cited by: 980
References: 85
Citations by year: 2026: 8 · 2025: 14 · 2024: 24 · 2023: 18 · 2022: 12 · 2021: 15 · 2020: 19 · 2019: 25 · 2018: 18 · 2017: 26 · 2016: 21 · 2015: 25 · 2014: 24 · 2013: 27 · 2012: 51
FWCI: 6.55
Type: journal article
Language: en
Open access: green
pure.eur.nl
Licence: other-oa
Locations: Science (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, other-oa)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Keywords: aging, frailty, muscle strength, estrogen, menopause, testosterone, andropause, dehydroepiandrosterone, dehydroepiandrosterone sulfate, growth hormone, insulin-like growth factor I, somatopause, hormone replacement therapy, oldest old
MeSH terms: Adrenal Glands, Aged, Aged, 80 and over, Aging, Animals, Climacteric, Dehydroepiandrosterone, Endocrine Glands, Female, Humans, Male, Menopause, Pituitary Gland, Testosterone, Estrogen Replacement Therapy, Frail Elderly, Human Growth Hormone

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