CoChat
Sign Up
Cited by 113Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesSexual Differentiation and DisordersWilliams Syndrome Research

Cardiac malformations and hypertension, but not metabolic risk factors, are common in Turner syndrome

Landin-Wilhelmsen, Kerstin, Bryman, Inger, Wilhelmsen, Lars·2001·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.86.9.7818
Open this paper in CoChat — free account

Abstract

Turner syndrome (TS) is caused by an X chromosome aberration and is characterized by endogenous estrogen deficiency secondary to ovarian dysgenesis and short stature. Our aim was to study the prevalence of cardiovascular malformations and cardiovascular risk factors (blood pressure, blood lipids and glucose, coagulation factors, social factors, smoking habits) in adults with Turner syndrome in comparison with a female random population sample. One hundred women with Turner syndrome (aged 16-71 yr) underwent physical examination, echocardiography, electrocardiography, and blood sampling. Seventy-one of them were matched for age [mean age, 33.7 +/- 11 yr (range, 25-64)] with a random population sample (n = 213) of women [mean age, 34.8 +/- 9 yr (range, 25-64)] from the World Health Organization's Monitoring of Trends and Determinants in Cardiovascular Diseases Project, Göteborg. Six percent of Turner syndrome women were smokers compared with 25% in the population (P < 0.001). Turner syndrome women were relatively heavier and had a lower degree of leisure time physical activity than controls (P < 0.001). Diabetes and treatment for hypertension were present in 3 and 22% among Turner syndrome women vs. 2% (not significant) and 3% (P < 0.001) in controls, respectively. Cardiovascular malformations were found among 17% in Turner syndrome women (45,X dominated) vs. 0.5% in controls (P < 0.001). Systolic but not diastolic blood pressure was higher in Turner syndrome women. No differences were seen in serum total cholesterol, high- or low-density lipoprotein cholesterol, triglycerides, lipoprotein (a), or plasma fibrinogen concentrations between patients and controls. Diabetes or hypertension was not related to karyotype. In conclusion, congenital cardiovascular malformations were frequent. Most cardiovascular risk factors (glucose and lipid levels, fibrinogen, smoking habits) were not increased, but hypertension was more common in Turner syndrome women.

Integrity signals

Registry

Crossref · 10.1210/jcem.86.9.7818

Cites

30 of 30 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • While increased levels of procoagulant factors and reduced protein C and S were reported in some individuals with TS, most studies have reported normal levels of clotting factors, fibrinolytic factors, and clotting times.

    “While increased levels of procoagulant factors and reduced protein C and S were reported in some individuals with TS,129,474 most studies have reported normal levels of clotting factors, fibrinolytic factors, and clotting times.455”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [455]

  • The prevalence of hypertension is as high as 20%-40% in children and up to 60% in adults with TS.

    “The prevalence of hypertension is as high as 20%-40% in children441,453 and up to 60% in adults with TS.357,452,454-456”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [455]

  • There does not seem to be a specific dyslipidemia associated with TS.

    “There does not seem to be a specific dyslipidemia associated with TS.331,455”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [455]

  • The available literature shows that girls and women with TS do not meet current general recommendations for physical activity, which is concerning because less physical activity has been associated with excess weight gain and hypertension in adults with TS.

    “The available literature shows that girls and women with TS do not meet current general recommendations for physical activity,357,455,496-498 which is concerning because less physical activity has been associated with excess weight gain and hypertension in adults with TS.”

    From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [455]

Cites

Flagged first, then by citations

1 of the 31 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Related

Authors
Landin-Wilhelmsen, K., Bryman, I., & Wilhelmsen, L.
Affiliations
Sahlgrenska University Hospital (SE)
ORCID
Bryman, Inger
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2001-09
Volume
86
Issue
9
Pages
4166-4170
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.86.9.7818
OpenAlex
W2037242308
Cited by
113
References
31
Citations by year
2025: 1 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 3
FWCI
2.73
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Life Sciences › Neuroscience › Developmental Neuroscience › Williams Syndrome Research
Keywords
Turner syndrome, congenital heart disease, hypertension, cardiovascular risk factors, smoking, diabetes mellitus, dyslipidemia, fibrinogen, karyotype, 45,X, adult women, cardiovascular anomalies
MeSH terms
Adult, Blood Pressure, Body Weight, Cardiovascular Diseases, Chromosomes, Diabetes Mellitus, Female, Fibrinogen, Heart Defects, Congenital, Humans, Hypertension, Karyotyping, Life Style, Lipids, Male, Middle Aged, Risk Factors, Gonadal Steroid Hormones, Turner Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review