Cited by 70Adipokines, Inflammation, and Metabolic DiseasesLipid metabolism and biosynthesisAdipose Tissue and Metabolism

Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio

LANDIN, K., LÖNNROTH, P., KROTKIEWSKI, M., HOLM, G., SMITH, U.·1990·European Journal of Clinical Investigation

Abstract

Abstract. Increased lipolysis in abdominal adipocytes has been suggested to be of importance for the insulin resistance typical for abdominal obesity. In order to differentiate between fat distribution, measured as waist/hip ratio (WHR), and amount of body fat, glucose disposal during a euglycaemic clamp as well as lipolysis in isolated cells from abdominal and gluteo‐femoral regions were studied in 20 obese and 20 lean postmenopausal women with a high (n= 10) and low (n= 10) WHR, respectively. The lipolytic response was increased in cells from obese women irrespective of region. Furthermore, lipolysis was enhanced in abdominal compared with the gluteo‐femoral cells in obese women with a high WHR. Fasting blood glucose and insulin were increased in both groups of obese women while the degree of insulin resistance was most pronounced in the obese women with a high WHR. It is concluded that increased body fat is associated with both insulin resistance and increased lipolysis, and that this relationship is stronger in the presence of a high WHR. A high WHR may increase the expression of obesity as a risk for insulin resistance and this may be mediated through an increased lipolytic rate.

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Registry

Crossref · 10.1111/j.1365-2362.1990.tb01922.x

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33 of 33 references verified0 citation errors · 0 not checkable

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Authors
LANDIN, K., LÖNNROTH, P., KROTKIEWSKI, M., HOLM, G., & SMITH, U.
Affiliations
Sahlgrenska University Hospital (SE)
Venue
European Journal of Clinical Investigation
Publisher
Wiley
Published
1990-10
Volume
20
Issue
s1
Pages
530-535
ISSN
  • 0014-2972 (ISSN-L)
  • 1365-2362
OpenAlex
W2034813068
Cited by
70
References
33
Citations by year
2024: 1 · 2023: 1 · 2022: 2 · 2019: 4 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 3
FWCI
2.24
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Clinical Investigation (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Vetenskapsrådet
  • Göteborgs Läkaresällskap
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
insulin resistance, adipocyte lipolysis, waist-to-hip ratio, abdominal obesity, body fat distribution, postmenopausal women, glucose disposal, euglycaemic clamp
MeSH terms
Adipose Tissue, Blood Glucose, Female, Humans, Insulin, Insulin Resistance, Lipolysis, Middle Aged, Obesity, Somatotypes, In Vitro Techniques

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