Increased insulin resistance and fat cell lipolysis in obese but not lean women with a high waist/hip ratio
Abstract
Abstract. Increased lipolysis in abdominal adipocytes has been suggested to be of importance for the insulin resistance typical for abdominal obesity. In order to differentiate between fat distribution, measured as waist/hip ratio (WHR), and amount of body fat, glucose disposal during a euglycaemic clamp as well as lipolysis in isolated cells from abdominal and gluteo‐femoral regions were studied in 20 obese and 20 lean postmenopausal women with a high (n= 10) and low (n= 10) WHR, respectively. The lipolytic response was increased in cells from obese women irrespective of region. Furthermore, lipolysis was enhanced in abdominal compared with the gluteo‐femoral cells in obese women with a high WHR. Fasting blood glucose and insulin were increased in both groups of obese women while the degree of insulin resistance was most pronounced in the obese women with a high WHR. It is concluded that increased body fat is associated with both insulin resistance and increased lipolysis, and that this relationship is stronger in the presence of a high WHR. A high WHR may increase the expression of obesity as a risk for insulin resistance and this may be mediated through an increased lipolytic rate.
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The mean glucose disposal rate was similar in abdominally obese women without PCOS in a previous study (11 mg/kg LBM/min) as in the women with PCOS with similar body composition in the present study.
“The mean glucose disposal rate was similar in abdominally obese women without PCOS in that study (11 mg/kg LBM/min) as in the women with PCOS with similar body composition of the present study.”
From Type 2 diabetes mellitus in women with polycystic ovary syndrome during a 24-year period: importance of obesity and abdominal fat distribution (2020) · cites this paper as Landin et al., 1990
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- Authors
- LANDIN, K., LÖNNROTH, P., KROTKIEWSKI, M., HOLM, G., & SMITH, U.
- Affiliations
- Sahlgrenska University Hospital (SE)
- ORCID
- SMITH, U.
- Venue
- European Journal of Clinical Investigation
- Publisher
- Wiley
- Published
- 1990-10
- Volume
- 20
- Issue
- s1
- Pages
- 530-535
- ISSN
- 0014-2972 (ISSN-L)
- 1365-2362
- OpenAlex
- W2034813068
- Cited by
- 70
- References
- 33
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2019: 4 · 2017: 1 · 2016: 3 · 2014: 3 · 2013: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vetenskapsrådet
- Göteborgs Läkaresällskap
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- insulin resistance, adipocyte lipolysis, waist-to-hip ratio, abdominal obesity, body fat distribution, postmenopausal women, glucose disposal, euglycaemic clamp
- MeSH terms
- Adipose Tissue, Blood Glucose, Female, Humans, Insulin, Insulin Resistance, Lipolysis, Middle Aged, Obesity, Somatotypes, In Vitro Techniques
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