The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The exogenous origin of trimethylamine in the mouse
Abstract
Although it is now generally regarded that the origin of urinary trimethylamine (TMA) is via the action of intestinal microflora on precursors such as choline, little direct evidence exists. The normal production of urinary TMA was shown to be absent in germ-free mice and greatly reduced in antibiotic-pretreated animals. Cohabitation of germ-free mice with conventional animals restored their ability to excrete TMA. This study invokes a fundamental role for the intestinal microflora in the provision of TMA from precursors within the food.
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“We know that gut microbiota are required for these nutrients to be converted to TMA because gnotobiotic mice do not produce such TMA (1,96), and antibiotic treatment of standard mice decreases TMA formation (1).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [1]
Citations
Cites
The metabolism of14C-labelled trimethylamine and its N-oxide in man
Al-waiz, M., Mitchell, S. C., Idle, J. R., & Smith, R. L. (1987) · Xenobiotica · doi:10.3109/00498258709043962 · Cited by 143
Self-citationde la Huerga, J., & Popper, H. (1951) · Journal of Clinical Investigation · doi:10.1172/jci102463 · Cited by 129
Endogenous formation of dimethylamine
Zeisel, S. H., daCosta, K.-A., & Fox, J. G. (1985) · Biochemical Journal · doi:10.1042/bj2320403 · Cited by 93
Metabolic effects of oral neomycin.
Asatoor, A. M., Mj, C., Emmerson, B. T., Johnson, J. R., Levi, A. J., & MILNE, M. D. (1967) · PubMed · Cited by 61
STUDIES ON TRIMETHYLAMINE OXIDE
Norris, E. R., & Benoit, G. J. (1945) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)43150-x · Cited by 34
Lowis, S., Eastwood, M. A., & Brydon, W. G. (1983) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)84764-7 · Cited by 19
Trimethylamine as a Normal Constituent of Human Blood, Urine and Cerebrospinal Fluid
Dorée, C., & Golla, F. (1911) · Biochemical Journal · doi:10.1042/bj0050306 · Cited by 16
Filippi, F. D. (1906) · Hoppe-Seyler´s Zeitschrift für physiologische Chemie · doi:10.1515/bchm2.1906.49.4-6.433 · Cited by 15
On the Alleged Occurrence of Trimethylamine in Urine
Erdmann, C. C. (1910) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)91541-3 · Cited by 13
Trimethylamin aus Menschenharn
Dessaignes (1856) · Justus Liebig s Annalen der Chemie · doi:10.1002/jlac.18561000208 · Cited by 12
Research works printed but not linked: 3
- Takeda, 1909, The determination of trimethylamine in the urine, Arch Ges Physiol, 129, 8
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- Fomin, 1936, The origin of trimethylamine in the urine of man and animals, Ukrainia Biochem J, 9, 143
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Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400
Dumas, M.-E., Barton, R. H., Toye, A., Cloarec, O., Blancher, C., Rothwell, A., Fearnside, J., Tatoud, R., Blanc, V., Lindon, J. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601056103 · Cited by 1,042
Self-citationNogal, A., Valdes, A. M., & Menni, C. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1897212 · Cited by 917
Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
Craciun, S., & Balskus, E. P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215689109 · Cited by 701
Metadata
- Authors
- Al-Waiz, M., Mikov, M., Mitchell, S. C., & Smith, R. L.
- Affiliations
- St Mary's Hospital (GB)
- Corresponding author
- Mitchell, S.C.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 41
- Issue
- 2
- Pages
- 135-136
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2089502105
- Cited by
- 196
- References
- 11
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- trimethylamine, gut microbiota, germ-free mice, antibiotic therapy, choline metabolism, dietary precursors
- MeSH terms
- Animals, Germ-Free Life, Male, Methylamines, Mice, Inbred Strains, Neomycin, Reference Values, Mice
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