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The exogenous origin of trimethylamine in the mouse
Abstract
Although it is now generally regarded that the origin of urinary trimethylamine (TMA) is via the action of intestinal microflora on precursors such as choline, little direct evidence exists. The normal production of urinary TMA was shown to be absent in germ-free mice and greatly reduced in antibiotic-pretreated animals. Cohabitation of germ-free mice with conventional animals restored their ability to excrete TMA. This study invokes a fundamental role for the intestinal microflora in the provision of TMA from precursors within the food.
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“We know that gut microbiota are required for these nutrients to be converted to TMA because gnotobiotic mice do not produce such TMA (1,96), and antibiotic treatment of standard mice decreases TMA formation (1).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [1]
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Metadata
- Authors
- Al-Waiz, M., Mikov, M., Mitchell, S. C., & Smith, R. L.
- Affiliations
- St Mary's Hospital (GB)
- Corresponding author
- Mitchell, S.C.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 41
- Issue
- 2
- Pages
- 135-136
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2089502105
- Cited by
- 196
- References
- 11
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 9 · 2023: 11 · 2022: 13 · 2021: 13 · 2020: 19 · 2019: 16 · 2018: 14 · 2017: 9 · 2016: 12 · 2015: 10 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- trimethylamine, gut microbiota, germ-free mice, antibiotic therapy, choline metabolism, dietary precursors
- MeSH terms
- Animals, Germ-Free Life, Male, Methylamines, Mice, Inbred Strains, Neomycin, Reference Values, Mice
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