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Cited by 143Pharmacogenetics and Drug MetabolismPolyamine Metabolism and ApplicationsAmino Acid Enzymes and Metabolism

The metabolism of14C-labelled trimethylamine and its N-oxide in man

Al-waiz, M., Mitchell, S. C., Idle, J. R., Smith, R. L.·1987·Xenobiotica
DOI 10.3109/00498258709043962
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Abstract

The metabolism and elimination of 14C-labelled trimethylamine and its N-oxide (100 mg orally) were studied in three male volunteers. For both compounds the urine was the major route of elimination, with 95% of the administered 14C being voided in the first 24 h. No radioactivity was found in expired air. The majority (greater than 95%) of the urinary 14C from both compounds was excreted as trimethylamine N-oxide.

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Crossref · 10.3109/00498258709043962

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28 of 28 references verified0 citation errors · 0 not checkable

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  • After radiolabeled TMA or TMAO is given to people, 94.5% of the dose label is excreted in urine within 24 h, 4% in feces, and less than 1% in breath.

    “After administration of radiolabeled TMA or TMAO to people, 94.5% of the dose label was excreted in the urine within 24 h; only 4% of the dose was excreted in the feces and <1% in the breath (2).”

    From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [2]

  • When radiolabeled trimethylamine or trimethylamine N-oxide were orally administered to human volunteers, 95% of the dose label was excreted via the kidneys with the majority being trimethylamine N-oxide.

    “When radiolabeled TMA or TMAO were orally administered to human volunteers, 95% of the dose label was excreted via the kidneys with the majority being TMAO77.”

    From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [77]

  • Healthy volunteers orally supplemented with choline exhibited higher levels of trimethylamine N-oxide and concomitant enhanced platelet responsiveness and aggregation.

    “In a subsequent human feeding study, healthy volunteers (both omnivore and vegan/vegetarian) that were orally supplemented with choline exhibited higher levels of TMAO and concomitant enhanced platelet responsiveness and aggregation77, 118.”

    From Gut microbiota and cardiovascular disease. (2020) · cites this paper as [77]

  • Under normal physiologic conditions, circulating TMAO is rapidly cleared almost exclusively by urinary excretion.

    “Under normal physiologic conditions, circulating TMAO is rapidly cleared almost exclusively by urinary excretion [44].”

    From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [44]

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Authors
Al-waiz, M., Mitchell, S. C., Idle, J. R., & Smith, R. L.
Affiliations
St Mary's Hospital (GB)
ORCID
Venue
Xenobiotica
Publisher
Informa UK Limited
Published
1987-01
Volume
17
Issue
5
Pages
551-558
ISSN
  • 0049-8254 (ISSN-L)
  • 1366-5928
DOI
10.3109/00498258709043962
OpenAlex
W2042398122
Cited by
143
References
28
Citations by year
2026: 5 · 2025: 9 · 2024: 10 · 2023: 6 · 2022: 13 · 2021: 10 · 2020: 11 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 6 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
3.43
Type
journal article
Language
en
Open access
closed
Locations
  • Xenobiotica (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Arabian Gulf University
  • Wellcome Trust
  • Flinders University
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Keywords
trimethylamine, trimethylamine N-oxide, urinary excretion, radiolabeled compounds, human metabolism, expired air
MeSH terms
Biotransformation, Chromatography, Thin Layer, Humans, Kinetics, Male, Methylamines, Mass Spectrometry

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