The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Carbohydrate fermentation decreases hepatic glucose output in healthy subjects
Abstract
Fermentation of undigested carbohydrate produces short-chain fatty acids (SCFA), some of which have been shown to reduce hepatic glucose production (HGP) in animals. The aim of this study was to examine whether carbohydrate fermentation decreases HGP in man. Ten healthy subjects consumed 90-g carbohydrate portions of either brown rice or barley for dinner in random order 1 week apart. The following morning, glucose kinetics were measured basally and during an oral glucose tolerance test (OGTT). HGP was calculated as the difference between the total rate of glucose appearance (calculated from % enrichment of 6,6 dideuterated glucose [6,6 D2 glucose]) and the rate of appearance of gut-derived glucose (calculated from 6-3H glucose in the glucose drink). To detect fermentation, breath H2 content was measured by end-expiratory sampling of alveolar air. Significantly more breath H2 was produced after barley consumption (24 +/- 4 v 4 +/- 1 ppm, P < .001), indicating that barley contains more fermentable carbohydrate than rice. Glucose tolerance improved after the barley meal, with the peak OGTT plasma glucose concentration being 0.7 mmol/L lower than that after the rice meal (7.7 +/- 0.4 v 8.4 +/- 0.3 mmol/L, P < .05). This was primarily due to a 30% reduction in HGP (area under the curve, 909 +/- 116 v 1,295 +/- 157 mumol/kg; P < .01). No difference in the rates of glucose disappearance or gut glucose absorption was observed. However, serum free fatty acid (FFA) concentrations were…
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“Evening meals of low GI produce better glucose tolerance the following morning compared with evening meals of high GI (Wolever et al. 1988b;Thorburn et al. 1993).”
From Glycaemic index methodology (2005) · cites this paper as Thorburn et al. 1993
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TOXIC-SHOCK SYNDROME NOT ASSOCIATED WITH MENSTRUATION
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Gut flora in health and disease
Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,480
Brouns, F., Bjorck, I., Frayn, K. N., Gibbs, A. L., Lang, V., Slama, G., & Wolever, T. M. S. (2005) · Nutrition Research Reviews · doi:10.1079/nrr2005100 · Cited by 1,093
Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults
Pereira, M. A., Jacobs, D. R., Pins, J. J., Raatz, S. K., Gross, M. D., Slavin, J. L., & Seaquist, E. R. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/75.5.848 · Cited by 548
Fiber and Magnesium Intake and Incidence of Type 2 Diabetes: A Prospective Study and Meta-analysis
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The potential use of cereal (1→3,1→4)-β-d-glucans as functional food ingredients
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Metadata
- Authors
- Thorburn, A., Muir, J., & Proietto, J.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Corresponding author
- Thorburn, Anne
- ORCID
- Muir, Jane
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 42
- Issue
- 6
- Pages
- 780-785
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2043515140
- Cited by
- 178
- References
- 40
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 6 · 2017: 1 · 2016: 5 · 2015: 5 · 2014: 9 · 2013: 9 · 2012: 5
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- carbohydrate fermentation, hepatic glucose production, short-chain fatty acids, barley, brown rice, breath hydrogen, glucose tolerance, free fatty acids, oral glucose tolerance test
- MeSH terms
- Adult, Analysis of Variance, Hordeum, Blood Glucose, Dietary Carbohydrates, Female, Fermentation, Glucose, Glucose Tolerance Test, Humans, Liver, Male, Reference Values, Oryza, Time Factors
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