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Cited by 129Thyroid Disorders and TreatmentsAdrenal Hormones and DisordersHormonal and reproductive studies

Reduced tissue thyroid hormone levels in fatal illness

Arem, Ridha, Wiener, Gregory J., Kaplan, S.Ginda, Kim, Han-Seob, Reichlin, Seymour, Kaplan, Michael M.·1993·Metabolism
DOI 10.1016/0026-0495(93)90266-q
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Abstract

Patients with severe nonthyroidal illnesses (NTIs) frequently have decreased serum concentrations of triiodothyronine (T3) and less often of thyroxine (T4) without clear evidence of hypothyroidism. To determine whether T3 and T4 levels are also reduced in the tissues, we analyzed autopsy samples from 12 patients dying of NTI and 10 previously healthy individuals dying suddenly from trauma. Mean serum T3, T4, and free T4 index values were lower by 79%, 71%, and 49%, respectively, in the NTI group than in controls, but serum thyrotropin (TSH) values did not differ significantly. Mean T3 concentrations in cerebral cortex, hypothalamus, pituitary, liver, kidney, and lung were lower in the NTI group than in controls by 43% to 76%, but mean values in heart and skeletal muscle did not differ significantly between the groups. The mean liver T4 concentration was 66% lower in the NTI group, but mean T4 concentrations in the cerebral cortex were similar in the two groups. These results indicate that many tissues may be deficient in thyroid hormones in patients with fatal NTI, although the severity of the reduction in thyroid hormone concentrations may vary from one organ to another.

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  • T3 concentrations in post mortem human hypothalamic samples of NTIS patients are lower compared to patients with acute death from trauma.

    “T3 concentrations in post mortem human hypothalamic samples of NTIS patients are lower compared to patients with acute death from trauma [38].”

    From An update on non-thyroidal illness syndrome (2021) · cites this paper as [38]

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Authors
Arem, R., Wiener, G. J., Kaplan, S. G., Kim, H.-S., Reichlin, S., & Kaplan, M. M.
Affiliations
Tufts University (US)
Corresponding author
Arem, Ridha
Venue
Metabolism
Publisher
Elsevier BV
Published
1993-09
Volume
42
Issue
9
Pages
1102-1108
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/0026-0495(93)90266-q
OpenAlex
W2038496971
Cited by
129
References
46
Citations by year
2025: 3 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 3 · 2017: 3 · 2016: 1 · 2015: 5 · 2014: 7 · 2013: 5 · 2012: 1
FWCI
1.74
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01am016684-14)
  • National Center for Research Resources (RR00054, M01RR000054)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
low T3 syndrome, triiodothyronine, thyroxine, hypothyroidism, serum thyroid hormones, thyroid-stimulating hormone, autopsy, liver, cerebral cortex, hypothalamus, pituitary gland
MeSH terms
Adult, Child, Female, Humans, Male, Middle Aged, Osmolar Concentration, Thyroxine, Tissue Distribution, Triiodothyronine, Critical Illness

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