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Cited by 222Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats

Niesink, R.J.M., Van Ree, J.M.·1989·Neuropharmacology
DOI 10.1016/0028-3908(89)90038-5
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Abstract

Pinning, as a measure for play, and social grooming were simultaneously studied in juvenile rats. Short-term social isolation increased both behavioural responses. This increase was attenuated by the opioid antagonist naltrexone, whilst the opiate, morphine, and the opioid peptide beta-endorphin, increased the responses. Pinning was more sensitive to the effects of naltrexone, whilst beta-endorphin stimulated particularly social grooming. Small doses of the dopaminergic drug, apomorphine, decreased both pinning and grooming behaviour of the short-term isolated rats. Some of the effects were partially antagonized by the dopamine antagonist haloperidol, and the neurolepticum-like peptide, desenkephalin-gamma-endorphin (DE-gamma-E). A small dose of haloperidol and DE-gamma-E stimulated social grooming in particular, whilst a larger dose of haloperidol decreased pinning and social grooming. It is concluded that both opioid and dopaminergic systems are implicated in the increase of pinning and social grooming induced by short-term social isolation. The differences in sensitivity of pinning and social grooming for opioid and dopaminergic drugs and peptides are discussed in relation to possible differences in the neural systems underlying both social activities.

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Crossref · 10.1016/0028-3908(89)90038-5

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1 of 1 references verified0 citation errors · 0 not checkable

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  • Social isolation increases the motivation to initiate play in adolescent rats.

    “Though individual play motivation can be influenced by several factors, social isolation increases the motivation to initiate play in adolescent rats, and the increase in play depends on the duration of isolation (Niesink & van Ree, 1989;Vanderschuren, Stein et al., 1995).”

    From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Niesink & van Ree, 1989

  • The increase in play after social isolation depends on the duration of isolation.

    “Though individual play motivation can be influenced by several factors, social isolation increases the motivation to initiate play in adolescent rats, and the increase in play depends on the duration of isolation (Niesink & van Ree, 1989;Vanderschuren, Stein et al., 1995).”

    From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Niesink & van Ree, 1989

  • A period of social isolation is often used to induce high rates of play behavior in rats within a short time interval.

    “A period of social isolation is often used to induce high rates of play behavior in rats within a short time interval (Niesink & van Ree, 1989;Panksepp & Beatty, 1980;Vanderschuren, Niesink, Spruijt, 1995;Vanderschuren, Stein, Wiegant, & van Ree, 1995).”

    From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Niesink & van Ree, 1989

  • The Play-In-Pairs test can be a useful tool for a relatively quick assessment of playfulness.

    “This result supports previous research suggesting that the Play-In-Pairs test can be a useful tool for a relatively quick assessment of playfulness (Niesink & van Ree, 1989;Pellis & McKenna, 1992;Vanderschuren, Stein et al., 1995).”

    From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Niesink & van Ree, 1989

  • The 3 hr isolation period was chosen because it was shown to induce a substantial increase of social play in rats without reaching a ceiling effect.

    “This isolation period was chosen because it was shown to induce a substantial increase of social play in rats, without reaching a ceiling effect (Niesink & van Ree, 1989;Vanderschuren, Niesink et al., 1995;Vanderschuren, Stein et al., 1995).”

    From Play in Rats: Association across Contexts and Types, and Analysis of Structure (2014) · cites this paper as Niesink & van Ree, 1989

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Authors
Niesink, R. J. M., & Van Ree, J. M.
Affiliations
Utrecht University (NL)
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
1989-04
Volume
28
Issue
4
Pages
411-418
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/0028-3908(89)90038-5
OpenAlex
W2043925850
Cited by
222
References
1
Citations by year
2026: 1 · 2025: 6 · 2024: 8 · 2023: 14 · 2022: 5 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 13 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 8 · 2013: 12 · 2012: 6
FWCI
1.50
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
social grooming, social isolation, opioid system, dopaminergic system, naltrexone, morphine, beta-endorphin, apomorphine, haloperidol, young rats, play behavior, social behavior
MeSH terms
Animals, Behavior, Animal, Dose-Response Relationship, Drug, Endorphins, Grooming, Haloperidol, Male, Morphine, Naltrexone, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Opioid, Social Behavior, Social Isolation, Rats

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