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Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo
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Cites
Yung-Chi, C., & Prusoff, W. H. (1973) · Biochemical Pharmacology · doi:10.1016/0006-2952(73)90196-2 · Cited by 12,922
Huettner, J. E., & Bean, B. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1307 · Cited by 751
Research works printed but not linked: 57
- Andine, 1991, Intra- and extracellular changes of amino acids in the cerebral cortex of the neonatal rat during hypoxic ischemi, Dev. Brain Res., 64, 155, 10.1016/0165-3806(91)90214-4 · doi:10.1016/0165-3806(91)90214-4
- Benveniste, 1984, Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43, 1369, 10.1111/j.1471-4159.1984.tb05396.x · DOI · Paper page
- Buisson, 1992, Striatal protection induced by lesioning the substantia-nigra of rats subjected to focal ischemia, J. Neurochem., 59, 1153, 10.1111/j.1471-4159.1992.tb08358.x · DOI
- Chen, 1992, Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity, J. Neurosci., 12, 4427, 10.1523/JNEUROSCI.12-11-04427.1992 · DOI · Paper page
- Clements, 1992, The time course of glutamate in the synaptic cleft, Science, 258, 1498, 10.1126/science.1359647 · DOI · Paper page
- Collingridge, 1990, Excitatory amino acid receptors and synaptic plasticity, Trends Pharmac. Sci., 11, 290, 10.1016/0165-6147(90)90011-V · DOI · Paper page
- Danysz, 1988, Learning impairment in rats by N-methyl-D-aspartate receptor antagonists, Neuropharmacology, 27, 653, 10.1016/0028-3908(88)90189-X · DOI · Paper page
- Danysz, 1994, Are NMDA antagonistic properties relevant for antiparkinsonian activity in rats? Case of amantadine and memantine, J. Neural Transm.—Parkinsons Sect., 7, 155, 10.1007/BF02253435 · DOI
- Danysz, 1995, Glutamate in CNS disorders — a revived target for drug development?, Drug News & Perspectives, 8, 261
- Dansyz, 1995, Modulation of learning processes by ionotropic glutamate receptor ligands, Behav. Pharmac.
- Dimpfel, 1995, Effects of memantine on synaptic transmission in the hippocampus in vitro, Arzneim. Forsch./Drug Res., 45, 773
- Ditzler, 1991, Efficacy and tolerability of memantine in patients with dementia syndrome, Arzneim. Forsch./Drug Res., 41, 773
- Erdö, 1991, Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and,N-methyl-D-aspartate, Eur. J. Pharmac., 198, 215, 10.1016/0014-2999(91)90625-Z · DOI
- Foster, 1987, The novel anticonvulsant (+)-MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain, Br. J. Pharmac., 91, 403, 10.1111/j.1476-5381.1987.tb10295.x · DOI · Paper page
- Globus, 1991, Comparative effect of transient global ischemia on extracellular levels of glutamate, glycine, and gamma-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat, J. Neurochem., 57, 470, 10.1111/j.1471-4159.1991.tb03775.x · DOI · Paper page
- Görtelmeyer, 1992, Memantine in the treatment of mild to moderate dementia syndrome. A double-blind placebo-controlled study, Arzneim. Forsch./Drug Res., 42, 904
- Grant, 1992, Comparison of the effects of the uncompetitive N-methyl-D-aspartate antagonist (+ / −)- 5 — aminocarbonyl -10,11- dihydro — 5H — dibenzo (c, d — cyclo — hepten-5, 10-imine (ADCI) with its structural analogs dizocilpine ((+)-MK-801) and carbamazepine on ethanol withdrawal seizures, J. Pharmac. Exp. Ther., 260, 1017
- Hashimoto, 1994, Dopamine has inhibitory and accelerating effects on ischemia-induced neuronal cell damage in the rat striatum, Brain Res. Bull., 33, 281, 10.1016/0361-9230(94)90195-3 · DOI
- Herron, 1986, Frequency-dependent involvement of NMDA receptors in the hippocampus: a novel synaptic mechanism, Nature, 322, 265, 10.1038/322265a0 · DOI · Paper page
- Jackisch, 1994, The antiparkinsonian drugs budipine and biperiden are use-dependent (uncompetitive) NMDA receptor antagonists, Eur. J. Pharmac., 264, 207, 10.1016/0014-2999(94)00528-1 · DOI
- Johnson, 1987, Glycine potentiates the NMDA response in cultured mouse brain neurons, Nature, 325, 529, 10.1038/325529a0 · DOI · Paper page
- Keilhoff, 1992, Memantine prevents quinolinic acid-induced hippocampal damage, Eur. J. Pharmac., 219, 451, 10.1016/0014-2999(92)90487-O · DOI
- Kemp, 1987, Non-competitive antagonists of excitatory amino acid receptors, Trends Pharmac. Sci., 10, 294
- Kornhuber, 1991, Effects of the 1 -amino-adamantanes at the (+)-MK-801-binding site of the NMDA-receptor-gated ion channel—a human postmortem brain study, Eur. J. Pharmac., 206, 297, 10.1016/0922-4106(91)90113-V · DOI · Paper page
- Kornhuber, 1994, Amantadine and memantine are NMDA receptor antagonists, J. Neural Transm. -Gen. Sect., 43, 91
- Leander, 1988, N-methyl-D-aspartate acid-induced lethality in mice: selective antagonism by phencyclidine-like drugs, Brain Res., 448, 115, 10.1016/0006-8993(88)91107-9 · DOI
- Leppik, 1988, MK-801 for epilepsy: a pilot study, Neurology, 38, 405
- Litchfield, 1949, A simple method of evaluating dose-effect experiments, J. Pharmac. Exp. Ther., 96, 99
- Lodge, 1990, Noncompetitive excitatory amino acid receptor antagonists, Trends Pharmac. Sci., 11, 81, 10.1016/0165-6147(90)90323-Z · DOI · Paper page
- Löscher, 1990, High doses of memantine (l-amino-3,5-dimethyladamantane) induce seizures in kindled but not in non-kindled rats, Naunyn-Schmiedbergs Arch. Pharmac., 341, 476
- Löscher, 1994, Over-additive anticonvulsant effect of memantine and NBQX in kindled rats, Eur. J. Pharmac., 259, R3, 10.1016/0014-2999(94)90514-2 · doi:10.1016/0014-2999(94)90514-2
- Luby, 1959, Study of a new schizophrenomimetic drug: Sernyl, Arch. Neurol. Psychiat., 81, 363, 10.1001/archneurpsyc.1959.02340150095011 · DOI · Paper page
- Lysko, 1992, Neuroprotective effects of carvedilol, a new antihypertensive, at the N-methyl-D-aspartate receptor, Neurosci. Lett., 148, 34, 10.1016/0304-3940(92)90798-C · DOI
- Mayer, 1984, Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurons, Nature, 309, 261, 10.1038/309261a0 · DOI · Paper page
- Meldrum, 1986, Anticonvulsantaction of l,3-dimethyl-5-aminoadamantane. Pharmacological studies in rodents and baboon, Papio Papio, Naunyn-Schmiedbergs Arch. Pharmac, 332, 93, 10.1007/BF00633204 · doi:10.1007/bf00633204
- Misztal, 1994, Learning impairment induced by chronic intraventricular infusion of quinolinic acid—a model of progressive excitotoxicity, Behav. Pharmac., 5, 55
- Mitani, 1992, Selective vulnerability of hippocampal CA1 neurons cannot be explained in terms of an increase in glutamate concentration during ischemia in the gerbil: Brain microdialysis study, Neuroscience, 48, 307, 10.1016/0306-4522(92)90492-K · DOI
- Nowak, 1984, Magnesium gates glutamate-activated channels in mouse central neurons, Nature, 307, 462, 10.1038/307462a0 · DOI · Paper page
- Nozawa, 1993, The neuroprotective properties of ES-242s, novel NMDA receptor antagonists, in neuronal cell culture toxicity studies, Eur. J. Pharmac., 236, 263, 10.1016/0014-2999(93)90597-B · doi:10.1016/0014-2999(93)90597-b
- Palmer, 1992, Biological profile of the metabolites and potential metabolites of the anticonvulsant remacemide, Epilepsy Res., 12, 9, 10.1016/0920-1211(92)90086-9 · doi:10.1016/0920-1211(92)90086-9
- Pantev, 1993, Clinical and behavioural evaluation in long-term care patients with mild to moderate dementia under Memantine treatment, Zeitschr. Gerontol. Psychiat., 6, 103
- Parsons, 1993, Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (1- amino-3,5-dimethyladamantan), Neuropharmacology, 32, 1337, 10.1016/0028-3908(93)90029-3 · DOI · Paper page
- Parsons, 1994, Comparative studies on NMDA receptor antagonism by amantadine (1-amino-adamantane) and memantine (1-amino-3,5-dimethyladamantane), Soc. Neurosci. Abstr., 20, 1144
- Rho, 1994, Mechanism of action of the anticonvulsant felbamate—opposing effects on N-methyl-D-aspartate and gamma-aminobutyric acid, receptors, Ann. Neurol., 35, 229, 10.1002/ana.410350216 · DOI · Paper page
- Rogawski, 1992, The NMDA receptor, NMDA antagonists and epilepsy therapy, Drugs, 44, 279, 10.2165/00003495-199244030-00001 · DOI · Paper page
- Rogawski, 1993, Therapeutic potential of excitatory amino acid antagonists: channel blockers and 2,3-benzodiazepines, Trends Pharmac. Sci., 14, 325, 10.1016/0165-6147(93)90005-5 · DOI · Paper page
- Rogawski, 1990, Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds, Pharmac. Rev., 42, 223
- Seif el Nasr, 1990, Neuroprotective effect of memantine demonstrated in vivo and in vitro, Eu. J. Pharmac., 185, 19, 10.1016/0014-2999(90)90206-L · DOI · Paper page
- Stieg, 1993, Post-stroke neuroprotection by memantine minimally affects behaviour and does not block LTP, Neurosci. Abstr., 19, 1503
- Sveinbjornsdottir, 1993, The excitatory amino acid antagonist D-CPP-ene (SDZ EAA-494) in patients with epilepsy, Epilepsy Res, 16, 165, 10.1016/0920-1211(93)90031-2 · DOI · Paper page
- Urbanska, 1992, Antiparkinsonian drugs memantine and trihexyphenidyl potentiate the anticonvulsant activity of valproate against maximal electroshock-induced seizures, Neuropharmacology, 31, 1021, 10.1016/0028-3908(92)90103-V · doi:10.1016/0028-3908(92)90103-v
- Weller, 1993, NMDA receptor-mediated glutamate toxicity of cultured cerebellar, cortical and mesencephalic neurons: neuroprotective properties of amantadine and memantine, Brain Res., 613, 143, 10.1016/0006-8993(93)90464-X · DOI
- Wenk, 1994, Investigations of neuroprotection within the nucleus basalis of the rat, Brain Res., 655, 7, 10.1016/0006-8993(94)91590-3 · DOI
- Wenk, 1995, MK-801, memantine and amantadine show potent neuroprotective activity against NMDA toxicity in the nucleus basalis—a dose response study, Eur. J. Pharmac., 10.1016/0926-6917(95)00028-3 · DOI
- Willets, 1990, The behavioural pharmacology of NMDA receptor antagonists, Trends Pharmac. Sci., 11, 423, 10.1016/0165-6147(90)90150-7 · DOI · Paper page
- Williams, 1991, Modulation of the NMDA receptor by polyamines, Life Sci., 48, 469, 10.1016/0024-3205(91)90463-L · DOI · Paper page
- Wong, 1988, [3H](+)-MK-801 labels a site on the N-methyl-d-aspartate receptor channel complex in rat, J. Neurochem., 50, 274, 10.1111/j.1471-4159.1988.tb13260.x · DOI · Paper page
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Self-citation
Metadata
- Authors
- Parsons, C. G., Quack, G., Bresink, I., Baran, L., Przegalinski, E., Kostowski, W., Krzascik, P., Hartmann, S., & Danysz, W.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 1995-10
- Volume
- 34
- Issue
- 10
- Pages
- 1239-1258
- ISSN
- 0028-3908 (ISSN-L)
- OpenAlex
- W2020789218
- Cited by
- 311
- References
- 2
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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- Parsons, C. G., Quack, G., Bresink, I., Baran, L., Przegalinski, E., Kostowski, W., Krzascik, P., Hartmann, S., & Danysz, W. (1995). Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo. Neuropharmacology. https://doi.org/10.1016/0028-3908(95)00092-k
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