Cited by 197Adipose Tissue and MetabolismLipid metabolism and biosynthesisAdipokines, Inflammation, and Metabolic Diseases

Postprandial Oxidative Metabolism of Human Brown Fat Indicates Thermogenesis

Open access
U Din, Mueez, Saari, Teemu, Raiko, Juho, Kudomi, Nobu, Maurer, Stefanie F., Lahesmaa, Minna, Fromme, Tobias, Amri, Ez-Zoubir +4 more·2018·Cell Metabolism

Abstract

Human studies suggest that a meal elevates glucose uptake in brown adipose tissue (BAT). However, in postprandial state the thermogenic activity and the metabolism of non-esterified fatty acids (NEFAs) in BAT remain unclear. Using indirect calorimetry combined with positron emission tomography and computed tomography (PET/CT), we showed that whole-body and BAT thermogenesis (oxygen consumption) increases after the ingestion of a mixed carbohydrate-rich meal, to the same extent as in cold stress. Postprandial NEFA uptake into BAT is minimal, possibly due to elevated plasma insulin inhibiting lipolysis. However, the variation in postprandial NEFA uptake is linked to BAT thermogenesis. We identified several genes participating in lipid metabolism to be expressed at higher levels in BAT compared with white fat in postprandial state, and to be positively correlated with BAT UCP1 expression. These findings suggest that substrates preferred by BAT in postprandial state are glucose or LPL-released NEFAs due to insulin stimulation.

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Crossref · 10.1016/j.cmet.2018.05.020

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Authors
U Din, M., Saari, T., Raiko, J., Kudomi, N., Maurer, S. F., Lahesmaa, M., Fromme, T., Amri, E.-Z., Klingenspor, M., Solin, O., Nuutila, P., & Virtanen, K. A.
Affiliations
  • University of Turku (FI)
  • Kagawa University (JP)
  • Technical University of Munich (DE)
  • Centre National de la Recherche Scientifique (FR)
  • Åbo Akademi University (FI)
Corresponding author
Virtanen, Kirsi A.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2018-08
Volume
28
Issue
2
Pages
207-216.e3
ISSN
1550-4131 (ISSN-L)
OpenAlex
W2808196629
Cited by
196
References
57
Citations by year
2026: 16 · 2025: 9 · 2024: 24 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 38 · 2019: 24 · 2018: 6
FWCI
17.26
Type
journal article
Language
en
Open access
Locations
  • Cell Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
  • Åbo Akademi University Research Portal (submittedVersion)
Funders
  • Academy of Finland (259926, 265204, 292839, 269977)
  • Paulo Foundation
  • Finnish Cultural Foundation Southwest Finland Regional
  • Turku University Hospital Research
  • European Union
  • ANR
  • DFG
  • University of Turku
  • Åbo Akademi University
Topics
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Keywords
brown adipose tissue, thermogenesis, postprandial state, free fatty acids, glucose uptake, oxygen consumption, insulin, lipolysis, UCP1, lipid metabolism genes, white adipose tissue, cold stress
MeSH terms
Diet, Carbohydrate Loading, Uncoupling Protein 1, Positron Emission Tomography Computed Tomography, Adult, Adipose Tissue, Brown, Fatty Acids, Nonesterified, Female, Humans, Insulin, Lipolysis, Male, Middle Aged, Obesity, Oxygen Consumption, Case-Control Studies, Postprandial Period, Thermogenesis, Adipose Tissue, White, Cold-Shock Response

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