Dose-dependent effects of hydrocortisone on memory in human males
Abstract
Eighty male undergraduates were administered either glucose or 5, 10, 20, or 40 mg of hydrocortisone in a double-blind procedure. After 60 min they were asked to listen to eight 12 word lists and then asked to recall the words. In addition to the expected effects of rate of presentation, serial position, and practice there was a significant interaction between dose of hydrocortisone and practice. Early recall was facilitated by all doses used whereas later recall was facilitated by treatment with 40 mg and impaired by treatment with 5 mg. These findings are discussed in the context of the effects of pituitary adrenocortical hormones and memory function.
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The physiological effects of glucocorticoids act in a curvilinear, or inverted U-shaped, manner on several cognitive systems, where moderate levels are optimal, while very low or high concentrations have distinct adverse cognitive outcomes.
“It appears that the physiological effects of glucocorticoids act in a curvilinear, or ‘inverted U-shaped’, manner on several cognitive systems, where moderate levels are optimal, while very low or high concentrations have distinct adverse cognitive outcomes (444, 445).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [444]
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- Authors
- Beckwith, B. E., Petros, T. V., Scaglione, C., & Nelson, J.
- Affiliations
- University of North Dakota (US)
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 36
- Issue
- 2
- Pages
- 283-286
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W2016813987
- Cited by
- 69
- References
- 25
- Citations by year
- 2025: 1 · 2023: 1 · 2019: 5 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cortisol, memory, word list recall, dose-response relationship, practice effects, serial position, presentation rate, adrenal cortex hormones, memory impairment
- MeSH terms
- Adolescent, Adult, Animals, Dose-Response Relationship, Drug, Double-Blind Method, Extinction, Psychological, Glucocorticoids, Humans, Hydrocortisone, Male, Memory, Rats
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