Prebiotic co-evolution of self-replication and translation or RNA world?
Abstract
A prebiotic scenario is proposed, based on the recent "domain hypothesis" model (Lahav, 1989, J. molec. Evol. 29, 475-479), suggested for domain propagation of RNA-like molecules in a fluctuating environment. The same system is suggested now not only for the evolution of ribozymes, but also for the evolution of directed peptide synthesis, as follows: Short, self-structured strands (termed prebioectons), each possessing a templatable domain which is chargeable by an amino acid, are the predecessors of tRNA (proto-tRNA). Complementary domains are formed on these prebioectons during an environmental cycle such as wetting-drying, followed by their dissociation from their template domain and ligation, to form the predecessor of mRNA (proto-mRNA). The evolution of directed peptide synthesis is suggested to be based on the ability of the charged prebioectons to attach preferentially to their complementary domains on the proto-mRNA. Two stages of this process are envisioned, namely: (a) Template-directed, random peptide synthesis taking place when non-specifically-charged prebioectons are sequentially attached each to its complementary domain on the proto-mRNA, followed by peptide bond formation. (b) Template-and-sequence-directed peptide synthesis, which can be realized after the "invention" of a catalytic molecule capable of specifically charging a proto-tRNA by an amino acid; this is the crucial evolutionary stage, where a crude genetic code becomes functional. Gradually, catalytic peptides and ribozymes are selected for their functions and evolve, while being encoded in the primitive "memory" of the emerging system. Thus, rather than the RNA monopoly postulated by the RNA World hypothesis, an early co-evolution of primitive enzymes and ribozymes is suggested.(ABSTRACT TRUNCATED AT 250 WORDS)
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The GNC code was promoted by the pre-tRNA/pre-mRNA interaction and coevolution.
“Perhaps GNC code was promoted by the pre-tRNA/pre-mRNA interaction and coevolution [116,117] (Figure 5A).”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [116]
The interaction between pre-tRNA and amino acids led to the development of the pre-mRNA strand and the primitive GNC genetic code.
“Here, we propose that the interaction between pre-tRNA and amino acids led to the development of the pre-mRNA strand and the primitive GNC genetic code [88,116].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [116]
These new generations of amino acids are not only template directed but also sequence-directed.
“These new generations of amino acids are not only template directed but also sequence-directed [116].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [116]
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- Authors
- Lahav, N.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Corresponding author
- Lahav, Noam
- Venue
- Journal of Theoretical Biology
- Publisher
- Elsevier BV
- Published
- 1991-08
- Volume
- 151
- Issue
- 4
- Pages
- 531-539
- ISSN
- 0022-5193 (ISSN-L)
- OpenAlex
- W1977185318
- Cited by
- 28
- References
- 42
- Citations by year
- 2024: 1 · 2023: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 2
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Theoretical Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- prebiotic evolution, RNA world, ribozymes, origin of the genetic code, wetting-drying cycles, aminoacylation, origin of translation
- MeSH terms
- Animals, Enzymes, Biological Evolution, Molecular Biology, Peptides, Ribosomes, RNA, Protein Biosynthesis
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