Animal model of depression: Pharmacological sensitivity of a hedonic deficit

Computational Handbook of Statistics.

Crofts, A., Bruning, J. L., & Kintz, B. L. (1969) · Journal of the American Statistical Association · doi:10.2307/2283756 · Cited by 2,328

Endogenomorphic Depression

Klein, D. F. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760160005001 · Cited by 601

GUSTATORY NERVE IMPULSES IN RAT, CAT AND RABBIT

Pfaffmann, C. (1955) · Journal of Neurophysiology · doi:10.1152/jn.1955.18.5.429 · Cited by 279

Amitriptyline and scopolamine in an animal model of depression

Katz, R. J., & Hersh, S. I. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90008-7 · Cited by 105

Further studies on a novel animal model of depression: Therapeutic effects of a tricyclic antidepressant

Roth, K. A., & Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90006-3 · Cited by 73

The Water Taste in Mammals.

Liljestrand, G., & Zotterman, Y. (1954) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1954.tb01177.x · Cited by 56

Manic depressive syndrome: a physiologic disease.

Sh, K. (1966) · PubMed · Cited by 9

Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats

Laeken, N. V., Pauwelyn, G., Dockx, R., Descamps, B., Brans, B. T., Peremans, K. Y., Baeken, C., Goethals, I., Vanhove, C., & Vos, F. D. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1899-8 · Cited by 18

Korean red ginseng water extract produces antidepressant-like effects through involving monoamines and brain-derived neurotrophic factor in rats

Chou, T.-W., Huang, H., Panyod, S., Huang, Y., & Sheen, L. (2023) · Journal of Ginseng Research · doi:10.1016/j.jgr.2023.01.003 · Cited by 14

Cytokines and glucocorticoid receptors are associated with the antidepressant-like effect of alarin

Zhuang, F., Zhou, X. P., Gao, X., Lou, D. W., Bi, X., Qin, S.-J., Sun, C., Ye, P., Wang, Y., Ma, T., et al. (2016) · Peptides · doi:10.1016/j.peptides.2016.01.002 · Cited by 16

Effects of chronic mild stress on rats selectively bred for behavior related to bipolar disorder and depression

Murray, R., Boss-Williams, K. A., & Weiss, J. M. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.05.042 · Cited by 14

Directional Indicator on Neural Oscillations as a Measure of Synaptic Plasticity in Chronic Unpredictable Stress Rats

Zhang, M., Zheng, C., Quan, M., An, L., Yang, Z., & Zhang, T. (2011) · Neurosignals · doi:10.1159/000329302 · Cited by 14

Effect of chronic variable stress on corticosterone levels and hippocampal extracellular 5-HT in rats with persistent differences in positive affectivity

Raudkivi, K., Mällo, T., & Harro, J. (2011) · Acta Neuropsychiatrica · doi:10.1111/j.1601-5215.2011.00619.x · Cited by 14

The Role of the Anterodorsal Thalami Nuclei in the Regulation of Adrenal Medullary Function, Beta-adrenergic Cardiac Receptors and Anxiety Responses in Maternally Deprived Rats under Stressful Conditions

Suárez, M. M., Rivarola, M. A., Molina, S. M., Levin, G. M., Enders, J., & Paglini, P. A. (2004) · Stress · doi:10.1080/10253890400010705 · Cited by 14

Brief periods of positive peer interactions mitigate the effects of total social isolation in young Octodon degus

Colonnello, V., Iacobucci, P., Anderson, M. P., & Panksepp, J. (2011) · Developmental Psychobiology · doi:10.1002/dev.20520 · Cited by 13

The effect of acupuncture on lateral habenular nucleus and intestinal microflora in depression model rats

Chen, W., Chen, Y., Aslam, M. S., Shen, J., Tong, T., Yan, S., Cheng, W., Huang, Z., Li, J., Liu, S., et al. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114627 · Cited by 14

Systematic review and meta-analysis of 10 years of unpredictable chronic stress in zebrafish

Gallas‐Lopes, M., Bastos, L. M., Benvenutti, R., Panzenhagen, A. C., Piato, Â., & Herrmann, A. P. (2023) · Lab Animal · doi:10.1038/s41684-023-01239-5 · Cited by 15

Peganum harmala L. seed extract attenuates anxiety and depression in rats by reducing neuroinflammation and restoring the BDNF/TrkB signaling pathway and monoamines after exposure to chronic unpredictable mild stress

Tekşen, Y., Gündüz, M. K., Berikten, D., Özatik, F. Y., & Aydın, H. E. (2024) · Metabolic Brain Disease · doi:10.1007/s11011-024-01416-6 · Cited by 13

Anti-depressive effect of Shuangxinfang on rats with acute myocardial infarction: Promoting bone marrow mesenchymal stem cells mobilization and alleviating inflammatory response

Wang, C., Hou, J., Du, H., Yan, S., Yang, J., Wang, Y., Zhang, X., Zhu, L., & Zhao, H. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.11.113 · Cited by 13

Assessing activity onset time and efficacy for clinically effective antidepressant and antimanic drugs in animal models based on dominant–submissive relationships

Malatyńska, E., Pinhasov, A., Creighton, C. J., Crooke, J. J., Reitz, A. B., Brenneman, D. E., & Lubomirski, M. S. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.05.004 · Cited by 13

Modeling hypohedonia following repeated social defeat: Individual vulnerability and dopaminergic involvement

Spierling, S. R., Mattock, M., & Zorrilla, E. P. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.04.016 · Cited by 15

Effects of (R)-(−)-1-(benzofuran-2-yl)-2-propylaminopentane hydrochloride [(−)-BPAP] in animal models of mood disorders

Tsunekawa, H., Noda, Y., Miyazaki, M., Yoneda, F., Nabeshima, T., & Wang, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.12.016 · Cited by 13

Carvacrol alleviates CUMS-induced depressive-like behaviors and cognitive impairment by reducing oxidative stress and neuroinflammation in mice

Valentim, J. T., da Silva, D. M. A., Capibaribe, V. C. C., Lopes, I. S., Rebouças, M. D. O., Araújo, L. A., Chaves, R. D. C., Campelo, M. D. S., Ribeiro, M. E. N. P., & de Sousa, F. C. F. (2024) · Behavioural Brain Research · doi:10.1016/j.bbr.2024.115135 · Cited by 12

Methods for Evaluating Sensory, Affective and Cognitive Disorders in Neuropathic Rodents

Palazzo, E., Marabese, I., Gargano, F., Guida, F., Belardo, C., & Maione, S. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200831153117 · Cited by 12

Achyranthes aspera ameliorates stress induced depression in mice by regulating neuroinflammatory cytokines

Gawande, D. Y., Barewar, S., Taksande, J., Umekar, M. J., Ghule, B., Taksande, B. G., & Kotagale, N. R. (2022) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2022.06.001 · Cited by 14

The Effects of Restraint Stress on Intake of Preferred and Nonpreferred Solutions in Rodents

Howell, L. A., Harris, R. B. S., Clarke, C., Youngblood, B. D., Ryan, D. H., & Gilbertson, T. A. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00223-6 · Cited by 12

EFFECTS OF NALOXONE, GLYCYRRHIZIC ACID, DEXAMETHASONE AND DEOXYCORTICOSTERONE IN REPETITIVE STRESS

Ainsah, O., Nabishah, B. M., Cb, O., & Khalid, B. (1999) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.1999.03052.x · Cited by 12

Taste and diet preferences as predictors of drug self-administration.

Gosnell, B. A., & Krahn, D. D. (1998) · PubMed · Cited by 12

Stress selectively reduces sugar + saccharin mixture intake but increases proportion of calories consumed as sugar by rats

Dess, N. K., & Choe, S. (1994) · Psychobiology · doi:10.3758/bf03327083 · Cited by 12

An overview of the behavioral, neurobiological and morphological effects of topiramate in rats exposed to chronic unpredictable mild stress

Aydın, S., Yazici, Z. G., KILIÇ, C., Ozozturk, B. E., & Kılıç, F. S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174578 · Cited by 13

Post-operative environmental enrichment improves spatial and motor deficits but may not ameliorate anxiety- or depression-like symptoms in rats following traumatic brain injury

Moritz, K. E., Geeck, K., Underly, R. G., Searles, M. A., & Smith, J. S. (2014) · Restorative Neurology and Neuroscience · doi:10.3233/rnn-140414 · Cited by 11

Similarities and Differences Between "Proactive" and "Passive" Stress-Coping Rats in Responses to Sucrose, NaCl, Citric Acid, and Quinine

Treesukosol, Y., Boersma, G. J., Oros, H., Choi, P. P., Tamashiro, K. L., & Moran, T. H. (2014) · Chemical Senses · doi:10.1093/chemse/bju002 · Cited by 11

Zhile Capsule Exerts Antidepressant-Like Effects through Upregulation of the BDNF Signaling Pathway and Neuroprotection

Wu, J., Zhang, T., Yu, L., Huang, S., Yu, Y., Yu, S., Li, J., Cao, Y., Wei, Z., Li, X., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010195 · Cited by 11

Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior

Rice, R. C., Gil, D. V., Baratta, A. M., Frawley, R. R., Hill, S. Y., Farris, S. P., & Homanics, G. E. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100603 · Cited by 12

Neuropeptide Y Reverses Chronic Stress-induced Baroreflex Hypersensitivity in Rats

Xie, F., Sun, L., Su, X., Wang, Y., Liu, J., Zhang, R., Wang, N., Zhao, J., Ban, T., Niu, H., et al. (2012) · Cellular Physiology and Biochemistry · doi:10.1159/000338500 · Cited by 10

Occlusal Disharmony—A Potential Factor Promoting Depression in a Rat Model

Zhang, S., Wu, L., Zhang, M., He, K., Wang, X., Lin, Y., Li, S., & Chen, J. (2022) · Brain Sciences · doi:10.3390/brainsci12060747 · Cited by 10

Psychiatric Disorders as Vulnerability Factors for Nicotine Addiction: What Have We Learned from Animal Models?

Foll, B. L., Ng, E., Ciano, P. D., & Trigo, J. M. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-319-13482-6_6 · Cited by 10

Affective Disruption During Forced Ethanol Abstinence in C57BL/6J and C57BL/6NJ Mice

Hartmann, M. C., Haney, M. M., Smith, C. G., Kumar, V., & Rosenwasser, A. M. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14443 · Cited by 10

The anhedonias: Clinical and neurobiological aspects

Olivares, J. M., & Berríos, G. E. (1998) · International Journal of Psychiatry in Clinical Practice · doi:10.3109/13651509809115352 · Cited by 10

Repeated treatment with selective serotonin reuptake inhibitors but not anxiolytics prevents the stress-induced deficit of fighting behavior.

Ossowska, G., Zebrowska-Łupina, I., Danilczuk, Z., & Klenk-Majewska, B. (2002) · PubMed · Cited by 10

Chronic fluoxetine treatment up‐regulates dopamine receptors in the mesolimbic forebrain of the rat

Hammer, R. P., Margulies, J. E., Lynn, A. B., & Brady, L. S. (1993) · Depression · doi:10.1002/depr.3050010204 · Cited by 10

Molecular programs underlying differences in the expression of mood disorders in males and females

Mena, F., & Benoit, L. (2019) · Brain Research · doi:10.1016/j.brainres.2019.05.016 · Cited by 9

Chronic stress sensitizes amphetamine-elicited 50-kHz calls in the rat: Dependence on positive affective phenotype and effects of long-term fluoxetine pretreatment

Vares, M., Metelitsa, M., Kõiv, K., Kaldmäe, M., Laugus, K., Tiitsaar, K., Shimmo, R., & Harro, J. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.05.014 · Cited by 10

Glutamate Chemical Exchange Saturation Transfer ( GluCEST ) MRI to Evaluate the Rapid Antidepressant Effects of Ketamine in the Hippocampus of Rat Depression Model

Li, H., Luo, X., Qi, K., Lv, Y., Kan, J., Yang, C., Lin, X., Tao, J., Zhang, W., Liu, Y., et al. (2023) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.28921 · Cited by 9

Combination Therapy of Salvianolic Acid and Fluoxetine Improves the Cognitive Function of Rats with Chronic Stress-induced Depression

Yu, L., An, C., Jia, L., Li, Y., Chen, Q., Zhen, F., Wang, S., & Wang, M. (2015) · World Neurosurgery · doi:10.1016/j.wneu.2015.09.071 · Cited by 9

Unpredictable and repeated negative stimuli increased emotional reactivity in male quail

Favreau-Peigné, A., Calandreau, L., Constantin, P., Bertin, A., Arnould, C., Laurence, A., Richard‐Yris, M., Houdelier, C., Lumineau, S., Boissy, A., et al. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.07.010 · Cited by 9

Stress causes cognitive impairment by affecting cholesterol efflux and reuptake leading to abnormalities in lipid metabolism of rats

Ye, R., Zhang, M., Zhang, S., Bai, S., Jiang, Z., Cai, Q., Cao, K., Shen, C., Shi, Y., Zhang, R., et al. (2020) · Journal of Integrative Neuroscience · doi:10.31083/j.jin.2020.01.1249 · Cited by 7

Neuroendocrine and behavioral consequences of untreated and treated depression in pregnancy and lactation.

Császár, E., Melicherčíková, K., & Dubovický, M. (2014) · PubMed · Cited by 8

Corticosterone Induces Depressive-Like Behavior in Female Peri-Pubescent Rats, but Not in Pre-Pubescent Rats

Nickle, T. R., Stanley, E. M., & Middlemas, D. S. (2020) · Chronic Stress · doi:10.1177/2470547020923711 · Cited by 8

Chronic ecologically relevant stress effects on reverse‐translated touchscreen assays of reward responsivity and attentional processes in male rats: Implications for depression

Gonzalez, P. M., Jenkins, A. R., LaMalfa, K. S., & Kangas, B. D. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16157 · Cited by 7

Repetitive transcranial magnetic stimulation (rTMS) for depressive-like symptoms in rodent animal models

Zoicas, I., Licht, C., Mühle, C., & Kornhuber, J. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105726 · Cited by 7

Modelos animais em psiquiatria: avanços e desafios

Nunes, E. A., & Hallak, J. E. C. (2014) · Revista Latinoamericana de Psicopatologia Fundamental · doi:10.1590/1415-4714.2014v17n3p528-10 · Cited by 8

Virgin coconut oil abrogates depression-associated cognitive deficits by modulating hippocampal antioxidant balance, GABAergic and glutamatergic receptors in mice

Edem, E. E., Ihaza, B. E., Fafure, A. A., Ishola, A. O., Nebo, K. E., Enye, L. A., & Akinluyi, E. T. (2021) · Drug Metabolism and Personalized Therapy · doi:10.1515/dmpt-2021-0126 · Cited by 7

Animal Models of Depression – Where Are We Going?

Slattery, D. A., & Cryan, J. F. (2010) · Modern trends in psychiatry · doi:10.1159/000319511 · Cited by 7

Effects of social housing on hippocampal dendrites and behavior in ovariectomized rats

Leedy, G. M., Barrows, L. F., & Clark, S. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.11.006 · Cited by 7

Modeling Affective Symptoms of Schizophrenia

Čulig, L., & Belzung, C. (2015) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-12-800981-9.00007-9 · Cited by 8

Emotional Reactivity to Incentive Downshift in Adult Rats Exposed to Binge-Like Ethanol Exposure During Adolescence

Lerma-Cabrera, J. M., Arévalo-Romero, C. A., Cortés-Toledo, G. A., Adriasola-Carrasco, A. A., & Carvajal, F. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00315 · Cited by 7

AVP and Glu systems interact to regulate levels of anxiety in BALB/cJ mice.

An, X., & Tai, F. (2014) · PubMed Central · doi:10.13918/j.issn.2095-8137.2014.4.319 · Cited by 7

The Effect of Stress on Spontaneous Nest Leaving Behavior in the Mouse: An Improved Model of Stress-Induced Behavioral Pathology

Stone, E. A., Zhang, Y., & Quartermain, D. (1997) · Stress · doi:10.3109/10253899709001104 · Cited by 7

Animal Models for Assessing Anxiolytic, Neuroleptic, and Antidepressant Drug Action

Greenshaw, A. J., Nguyen, T. V., & Sanger, D. J. (2003) · Humana Press eBooks · doi:10.1385/0-89603-121-7:379 · Cited by 7

Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model

Lin, Y., Lin, H.-P., Lu, K., Huang, Y., Panyod, S., Liu, W.-T., Lu, Y.-S., Chen, M.-H., & Sheen, L. (2024) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2024.05.003 · Cited by 6

Dehydroepiandrosterone increases the number and dendrite maturation of doublecortin cells in the dentate gyrus of middle age male Wistar rats exposed to chronic mild stress

Herrera‐Perez, J. J., Martı́nez-Mota, L., Jiménez-Rubio, G., Ortiz-López, L. I., Cabrera-Muñoz, E. A., Galindo-Sevilla, N., Zambrano, E., Hernández‐Luis, F., Ramírez-Rodríguez, G. B., & Flores‐Ramos, M. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.01.007 · Cited by 7

Stress, Conflict, and Depression

Katz, R. J. (1983) · Springer eBooks · doi:10.1007/978-3-642-69129-4_8 · Cited by 6

Affective Behavior in Withdrawal Seizure–Prone and Withdrawal Seizure–Resistant Mice during Long‐Term Alcohol Abstinence

Hartmann, M. C., Holbrook, S. E., Haney, M. M., Crabbe, J. C., & Rosenwasser, A. M. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14074 · Cited by 5

Cytokine-Induced Sickness Behavior and Depression

Chang, Q., Szegedi, S. S., O’Connor, J. C., Dantzer, R., & Kelley, K. W. (2008) · Springer eBooks · doi:10.1007/978-0-387-84851-8_9 · Cited by 5

Treatment interventions following prenatal stress and neonatal cortical injury

Halliwell, C. (2011) · Open ULeth Scholarship (OPUS) (University of Lethbridge) · Cited by 5

Blunted anticipation but not consummation of food rewards in depressionPreprint

Schulz, C., Klaus, J., Peglow, F., Ellinger, S., Kühnel, A., Walter, M., & Kroemer, N. B. (2024) · medRxiv · doi:10.1101/2024.03.26.24304849 · Cited by 8

Glabridin Improves Depression-Like Behaviors in Mice by Modulating Neuroinflammation via MAPK/NF-κB Signaling Pathway

Shan, M., Zhang, J., Yang, F., Cao, F., Yang, Y., Li, W., & Wang, L. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04593-7 · Cited by 6

Blunted anticipation but not consummation of food rewards in depression

Schulz, C., Klaus, J., Peglow, F., Ellinger, S., Kühnel, A., Walter, M., & Kroemer, N. B. (2024) · Cell Reports Medicine · doi:10.1016/j.nsa.2024.103981 · Cited by 4

Neural Basis of Anhedonia Associated with Stress-Induced Eating Disorders

Jahng, J. W. (2014) · Springer eBooks · doi:10.1007/978-94-017-8591-4_13 · Cited by 4

Behavioural and neurobiological consequences of 2 different chronic stressors in rats

Dönmez, R. A., Yertutanol, F. D. K., Derinöz, O., EMMEZ, Ö. H., Candansayar, S., & Bolay, H. (2014) · TURKISH JOURNAL OF MEDICAL SCIENCES · doi:10.3906/sag-1309-24 · Cited by 4

5-HT4 Receptor Subtype, β-Arrestin Level, and Rapid-Onset Effects of Antidepressant Drugs

Mendez-David, I., David, D. J., Guilloux, J.-P., Hen, R., & Gardier, A. M. (2015) · Neuromethods · doi:10.1007/978-1-4939-2187-4_6 · Cited by 4

Optimizing Choice and Timing of Behavioral Outcome Tests After Repetitive Mild Traumatic Brain Injury: A Machine Learning-Based Approach on Multiple Pre-Clinical Experiments

Lassarén, P., Conley, G. M., Boucher, M. L., Conley, A. N., Morriss, N. J., Qiu, J., Mannix, R., & Thelin, E. P. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0486 · Cited by 4

Animal Models for Depression: The Anhedonic Rat - Theory and Practice

Matthews, K., & Reid, I. (1998) · KARGER eBooks · doi:10.1159/000058881 · Cited by 4

The Role of Animal Models in Reward Deficit Disorders: Views from Academia

Koob, G. F. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00024-2 · Cited by 4

[Influence of experimental context on the development of anhedonia in male mice exposed to chronic social stress].

Bondar, N. P., Kovalenko, I. L., Avgustinovich, D. F., & Nn, K. (2008) · PubMed · Cited by 4

Effects of a single inescapable swim on long-term brain stimulation reward thresholds

Valentino, D. A., Dufresne, R. L., & Riccitelli, A. J. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90303-l · Cited by 4

The Role of Slow Changes in Catecholamine Receptor Function in The Action Of Antidepressant Drugs

Willner, P. (1990) · International Review of Psychiatry · doi:10.3109/09540269009028279 · Cited by 4

Adult crowding induces sexual dimorphism in chronic stress-response in Drosophila melanogasterPreprint

Lall, S., Mudunuri, A., Santhosh, S., Malwade, A., Thadi, A., Kondakath, G., & Dey, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/702357 · Cited by 4

Predicting Future Development of Stress-Induced Anhedonia From Cortical Dynamics and Facial ExpressionPreprint

Coley, A. A., Batra, K., Delahanty, J., Keyes, L. R., Pamintuan, R., Ramot, A., Hagemann, J., Lee, C. R., Liu, V., Adivikolanu, H., et al. (2024) · Research Square · doi:10.1101/2024.12.18.629202 · Cited by 3

Neuroimmunomodulation: The History of Science in Psychoneuroimmunology

Kuhn, A. M., Bosis, K. E., & Wohleb, E. S. (2024) · NeuroImmunoModulation · doi:10.1159/000541592 · Cited by 5

IMPAIRED OBJECT RECOGNITION MEMORY AND ACETYLCHOLINESTERASE ACTIVITY IN ANIMAL MODEL OF POST-TRAUMATIC STRESS DISORDER-RESTORED BY ECLIPTA ALBA LINN. A DIETARY HERB.

Vinay, V. S., Malathi, S., & Ravindran, R. (2016) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2016.v9s3.14190 · Cited by 3

The Therapeutic Effect and Potential Pharmacological Mechanisms of Ding-Zhi-Xiao-Wan on Depression were Investigated by Meta-analysis, Network Pharmacology and Molecular Docking

Lin, L., Wu, H.-B., & Qiu, Z.-K. (2023) · Current Computer - Aided Drug Design · doi:10.2174/1573409919666230417103355 · Cited by 4

Nerolidol reduces depression-like behavior in mice and suppresses microglia activation by down-regulating DNA methyltransferase 1

Zhang, G., Zhou, X., Feng, Q., Ke, W., Pan, J., Zhang, H., Luan, Y., & Lei, B. (2024) · Neuroreport · doi:10.1097/wnr.0000000000002029 · Cited by 3

Two paradigms of research and their influence on the study of animal behaviour

Fraser, D. J. (2025) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2025.106550 · Cited by 3

Sex-dependent effects of stress on aIC-NAc circuit neuroplasticity: Role of the endocannabinoid system

Gauthier, M., Hebert, L.-P., Dugast, E., Lardeux, V., Letort, K., Thiriet, N., Belnoue, L., Balado, É., Solinas, M., & Belujon, P. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111335 · Cited by 3

Region-Specific Long-Term Transcriptional Changes in the Plasminogen Activation System and Neuroinflammation in the Rat Brain After Status Epilepticus: Association with Depressive-like Behavior

Karan, A. A., Selivanova, E., Spivak, Y. S., & Suleymanova, E. M. (2025) · Brain Sciences · doi:10.3390/brainsci15101083 · Cited by 3

The internal link of serum steroid hormones levels in insomnia, depression, and Alzheimer's disease rats: Is there an effective way to distinguish among these three diseases based on potential biomarkers?

Yang, X., Wang, Z., Zhang, Q., Liu, R., Xu, H., Bi, K., & Li, Q. (2019) · Journal of Separation Science · doi:10.1002/jssc.201801298 · Cited by 3

Antidepressant-like effects of Jieyu Chufan capsules in the olfactory bulbectomy rat model

Zhao, C. Y., Wang, M., Li, T., Song, T., Cui, W., Zhang, Q.-Y., & Hou, Y. (2023) · Brain Research · doi:10.1016/j.brainres.2023.148676 · Cited by 3

CHRONIC UNPREDICTABLE STRESS-INDUCED BEHAVIORAL AND ELECTROPHYSIOLOGICAL ALTERATIONS AND ITS AMELIORATIVE EFFECT BY MYRICETIN MICROEMULSION

Govindaraj, S., Deva Karunya, M., Prajisha, P., Cs, K., & Rajan, R. (2018) · Asian Journal of Pharmaceutical and Clinical Research · doi:10.22159/ajpcr.2018.v11i3.23364 · Cited by 3

Non-Response to Initial Antidepressant Therapy

Guilloux, J., David, D. J. P., Samuels, B. A., Mendez‐David, I., Gardier, A. M., & Guiar, B. P. (2012) · InTech eBooks · doi:10.5772/37783 · Cited by 4

Behavioral and Neurohormonal Sequelae of Prenatal Stress: A Suggested Model of Depression

Weinstock, M. (2000) · Neurobiological foundation of aberrant behaviors · doi:10.1007/978-1-4757-4860-4_4 · Cited by 3

Differential effects of chronic restraint stress on two active avoidance tasks in rats

López-Moraga, A., Ceuninck, M. D., der Heyden, Y. V., Vercammen, L., Palme, R., Vervliet, B., Beckers, T., & Luyten, L. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111586 · Cited by 2

Comparative analysis of multiple chronic unpredictable mild stress paradigms in mice: Behavioural and physiological validity

Erkizia-Santamaría, I., Fernández, L., Horrillo, I., Meana, J. J., & Ortega, J. E. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100815 · Cited by 4

Etiopathogenesis of depression and experimental depression models used in preclinical studies

Kandemir, Ü. (2023) · European Journal of Life Sciences · doi:10.55971/ejls.1327521 · Cited by 2

DEVELOPING CHRONIC UNPREDICTABLE/ALTERNATING STRESS MODEL IN WISTAR ALBINO RATS

Khattak, M., Malik, M. O., Usman, R., Habib, S. H., & Saddique, U. (2023) · Journal of Population Therapeutics and Clinical Pharmacology · doi:10.53555/jptcp.v30i19.3623 · Cited by 2

The potential biological mechanisms of obesity effects on depression: A systematic review of the literature and knowledge mining

Gong, Y., Wang, D., Zhang, X., Qu, Z., Liu, P., & Zou, H. (2013) · Health · doi:10.4236/health.2013.511244 · Cited by 2

Animal Models for Psychological Disorders

Murison, R. C. C., & Milde, A. M. (2011) · CRC Press eBooks · doi:10.1201/b10837-4 · Cited by 2

Experimental Models of Depression: An Overview to Validity and Reliability Criteria

Özkartal, C. Ş., & Arıcıoğlu, F. (2017) · Turkiye Klinikleri Journal of Laboratory Animals · doi:10.5336/jlabanim.2017-59277 · Cited by 2

Reduction of Submissive Behavior Model for Antidepressant Drug Testing in Mice

Malatyńska, E., Pinhasov, A., & Knapp, R. J. (2009) · Neuromethods · doi:10.1007/978-1-60761-303-9_15 · Cited by 2

[Validation of a rapid urease test for the diagnosis of Helicobacter pylori infection].

Cifuentes, P., Topor, J., Avagnina, A., Elsner, B., Moore, R. G., Barberis, C. M., Albarenga, K., & Antelo, P. (2002) · PubMed · Cited by 2

Experimental research

Montero, A., Fernández, B., & Romero, L. I. (2007) · Wiley eBooks · doi:10.1002/9783527619337.ch4 · Cited by 2

Ten years of unpredictable chronic stress in zebrafish: a systematic review and meta-analysisPreprint

Gallas‐Lopes, M., Bastos, L. M., Benvenutti, R., Panzenhagen, A. C., Piato, Â., & Herrmann, A. P. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.12.520151 · Cited by 2

Chronic mild stress - an anmial model of depression : from behavior to molecules

Grønli, J. (2006) · NORA - Norwegian Open Research Archives · Cited by 2

Aberrant Light-Induced Depression is Associated with Impaired Sensorimotor Gating in Mice

Haga, T., Toei, J., Mitsui, K., Ohtsuji, M., Kodera, Y., Osada, K., & Nishimura, H. (2017) · World Journal of Neuroscience · doi:10.4236/wjns.2018.81001 · Cited by 1

Transcription-Driven Repurposing of Cardiotonic Steroids for Lithium Treatment of Severe Depression

Killick, R., Hooper, C., Fernandes, C., Elliott, C., Aarsland, D., Kjosavik, S. R., Oesterhus, R., & Williams, G. H. (2025) · Cells · doi:10.3390/cells14080575 · Cited by 1

Royal Jelly Effect on Chronic Unpredictable Stress‐Induced Pancreatic Oxidative and Endoplasmic Reticulum Stress and Insulin Secretion Impairment in Adult Male Rats

Shahsavar, P., Binayi, F., Izadi, M. S., Salimi, M., Hedayati, M., Ghasemi, R., & Zardooz, H. (2025) · Journal of Food Biochemistry · doi:10.1155/jfbc/8812441 · Cited by 1

Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine

Monleón, S., Parra, A., SIMON, V. M., Brain, P. F., D’Aquila, P. S., & Willner, P. (1995) · Psychopharmacology · doi:10.1007/bf02246218 · Cited by 242

Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine

Harkin, A., Houlihan, D. D., & Kelly, J. P. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600201 · Cited by 102

Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant

Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993

Pharmacological validation of the chronic mild stress model of depression

Papp, M., Moryl, E., & Willner, P. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00697-4 · Cited by 205

Dopaminergic mechanism of imipramine action in an animal model of depression

Muscat, R., Sampson, D., & Willner, P. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90577-o · Cited by 126