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Animal model of depression: Pharmacological sensitivity of a hedonic deficit
Open accessAbstract
A reduction in sucrose and saccharine consumption following chronic stress is reported for the rat. This deficit may be related to consummatory deficits seen in endogenous depression. To further examine this state pharmacologically, stressed rats were treated with the antidepressant imipramine. Despite a general absence of appetitive effects (or in some cases mild anorexia) imipramine significantly restored saccharine consumption in a variety of tests. The pharmacological similarity of the deficit to the changes accompanying affective disorders further supports the potential applicability of the chronic stress model.
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Citations
Cites
Computational Handbook of Statistics.
Crofts, A., Bruning, J. L., & Kintz, B. L. (1969) · Journal of the American Statistical Association · doi:10.2307/2283756 · Cited by 2,328
Klein, D. F. (1974) · Archives of General Psychiatry · doi:10.1001/archpsyc.1974.01760160005001 · Cited by 601
GUSTATORY NERVE IMPULSES IN RAT, CAT AND RABBIT
Pfaffmann, C. (1955) · Journal of Neurophysiology · doi:10.1152/jn.1955.18.5.429 · Cited by 279
Amitriptyline and scopolamine in an animal model of depression
Katz, R. J., & Hersh, S. I. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90008-7 · Cited by 105
Self-citationRoth, K. A., & Katz, R. J. (1981) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(81)90006-3 · Cited by 73
Self-citationLiljestrand, G., & Zotterman, Y. (1954) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1954.tb01177.x · Cited by 56
Manic depressive syndrome: a physiologic disease.
Sh, K. (1966) · PubMed · Cited by 9
Cited by
Sorted by citations
Items 401–478 of 478
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Ilmer, I., & Smoleń, T. (2025) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2025.106753 · Cited by 2
Mukhoti, A., Annapoorna, P. K., Kumar, A., Wadnerkar, P., Khan, A. A., Pathak, S. S., Chakravarty, S., & Kumar, A. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-025-01597-3 · Cited by 1
Pérez, T. G. O., Pérez-Sánchez, E., Garduño, V. G. N., Corona‐Pérez, A., Arteaga, L., Lucio, R. A., Rodríguez‐Antolín, J., & Nicolás‐Toledo, L. (2025) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2025.114823 · Cited by 1
Assessment of serum leptin and thyroid hormone levels among depressed women.
Ahmadi, S. M., Eftekhari, M. H., Firoozabadi, A. D., & Keshavarzi, S. (2012) · Shiraz E-Medical Journal · Cited by 1
München, L.-M.-U. (2013) · Cited by 1
Mental stress studies in animals
Ding, Y., Guo, S., & Elmadhoun, O. (2018) · Environmental Disease · doi:10.4103/ed.ed_10_18 · Cited by 1
Interactions of Stress, Psychology, and Cardiovascular Function
Grippo, A. J., & Ciosek, S. (2023) · Masterclass in neuroendocrinology · doi:10.1007/978-3-031-39995-4_8 · Cited by 1
Chen, Y., Su, Z., Tang, B., Cao, J., Chen, Z., Cai, W., Li, C., Guo, Z., Cai, J. Q., Zhou, T., et al. (2023) · International Journal of Pharmacology · doi:10.3923/ijp.2023.673.690 · Cited by 1
A high salt intake in early life affects stress-coping response in males but not in female rats
Lago, M. W., Marques, L. S., Jung, J. T. K., Felipeto, V., & Nogueira, C. W. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114498 · Cited by 1
Sanchez, J. P. B., Wilzopolski, J., Hohlbaum, K., & Kalliokoski, O. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115483 · Cited by 1
Lima, C. N. D. C., da Silva, F. E. R., de Carvalho, M. A. J., Lima, J. E. D. C., Chaves-Filho, A. J. M., Fries, G. R., Sobreira-Neto, M. A., Costa, D. V. D. S., Fonteles, M. M. D. F., & Macêdo, D. S. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111443 · Cited by 1
Teal, L. B., Ingram, S., Bubser, M., McClure, E. W., & Jones, C. K. (2023) · Advances in neurobiology · doi:10.1007/978-3-031-21054-9_3 · Cited by 2
Possíveis inter-relações entre a submissão ao Chronic Mild Stree(CMS) e o desempenho operante
Thomaz, C. R. D. C. (2009) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.47.2009.tde-26112009-135126 · Cited by 1
Rodent Models as Tools for Discovering Novel Therapeutic Targets in the Brain: The Case of Epilepsy
Botterill, J. J., Guskjolen, A. J., Kalynchuk, L. E., & Caruncho, H. J. (2012) · doi:10.1002/9781118185537.ch13 · Cited by 1
Models of Affective Illness: Chronic Mild Stress
Papp, M. (1998) · Current Protocols in Pharmacology · doi:10.1002/0471141755.ph0509s01 · Cited by 1
Monoaminergic mechanisms in mood-associated behaviours and neurochemistry in rats
Häidkind, R. (2004) · DSpace repository (University of Tartu) · Cited by 1
(Pharmako-)Biologische und psychologische Grundlagenforschung
Schuurman, T., van der Staay, F. J., Traber, J., Spiegel, R., Saletu, B., Janke, W., & Erdmann, G. (1992) · Springer eBooks · doi:10.1007/978-3-7091-6674-1_3 · Cited by 1
Animal Models for Affective Disorders
McKinney, W. T. (1988) · Springer eBooks · doi:10.1007/978-1-4684-5430-7_4 · Cited by 1
MacKay, J. C. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5621 · Cited by 1
Psychopharmacological analysis of some behavioural models of depression
Porsolt, R. D. (1986) · Psychiatry and Psychobiology · doi:10.1017/s0767399x00003230 · Cited by 1
Chen, Z. (2019) · Työväentutkimus Vuosikirja · Cited by 1
Demin, K. A., Kolesnikova, T. O., Galstyan, D. S., Krotova, N. A., Ilyin, N. P., Derzhavina, K. A., Seredinskaya, M. V., Kositsyn, Y. M., Sorokin, D. V., Nerush, M. O., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.05.471274 · Cited by 1
Matthews, K., & Stewart, C. A. (2007) · Elsevier eBooks · doi:10.1016/b978-012373947-6.00118-5 · Cited by 1
Mendez‐David, I. (2013) · theses.fr (ABES) · doi:10.70675/3b74ce4cz68acz4446zbe46zb1542d4e9391 · Cited by 1
de Vasconcellos, A. P. S. (2005)
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Onksen, J. L. (2011) · ScholarlyCommons (University of Pennsylvania)
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Baþar, K., & Ertuðrul, A. (2005)
Animal Models of Affective Behaviors and Drug Addiction
Drews, E., Becker, A., Bilkei‐Gorzó, A., & Zimmer, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-79251-4_10
Drs. Harkness and Monroe Reply
Harkness, K. L., & Monroe, S. M. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1188-a
Caldecott-Hazard, S., & Weissman, A. D. (1992) · Springer eBooks · doi:10.1007/978-94-011-2712-7_13
Kanarik, M. (2007) · DSpace repository (University of Tartu)
ESTRESSE MODERADO CRÔNICO: EFEITOS SOBRE A ATIVIDADE GERAL EM RATOS
Oliveira, A. C. D. F. (2009)
Modeling Depression in the Rat: The Development and Usefulness of a Female-centric Approach
Baker, S. (2011) · uO Research (University of Ottawa) · doi:10.20381/ruor-4807
(2013) · De Gruyter eBooks · doi:10.1515/9783110814569.285
Social separation models of depression
Matthews, K. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511550072.017
Quetiapina: recenti sviluppi della ricerca preclinica
Orsetti, M., DiBrisco, F., Mauro, M., Dallorto, D., & Ghi, P. (2010) · Institutional Research Information System University of Turin (University of Turin)
Heart rate variability in animal models of psychological-cardiovascular comorbidity
Trombini, M. (2012) · DSpaceUnipr (University of Parma)
Moreines, J. L. (2017) · D-Scholarship@Pitt (University of Pittsburgh)
Odem, M. A. (2018) · Digital Commons-TMC (Texas Medical Center)
Translational research from animal models
Grippo, A. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815015-3.00003-9
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Giacometti, L. L., Buck, L. A., & Raghupathi, R. (2020) · Springer eBooks · doi:10.1007/978-3-030-44754-0_17
Chen, X., Liu, X., Zuo, X., Cheng, C., Huang, W. C., & Xie, P. (2020) · PubMed Central
RetractedExperimental Models of Depression
Albayrak, İ. (2021) · Journal of Experimental and Basic Medical Sciences · doi:10.5606/jebms.2020.75626
Reuveni, N. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/9989-0442
Thouaye, M., Fillinger, C., & Yalçın, İ. (2022) · Douleur et Analgésie · doi:10.3166/dea-2022-0228
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Yamanaka, H., Ishibashi, H., & Nakamura, K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.08.602574
Wang, L., Yuan, F., Yuan, Q., Dai, G., Lu, X., Zhou, L., Zheng, Y., Wu, Y., Wang, M., & Chen, G. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40428
Demin, K. A., Kolesnikova, T. O., Galstyan, D. S., Krotova, N. A., Ilyin, N. P., Derzhavina, K. A., Seredinskaya, M. V., Nerush, M. O., Pushkareva, S. A., Masharsky, A., et al. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70025 · Cited by 1
Conrad, C. D., Peay, D. N., Sladkova, S., Kim, J. L., Donnay, M. E., Acuña, A. M., & Whittaker, K. E. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1553501
Sofla, M. A. M., Gholami, M., Vaseghi, S., Barikrow, N., & Yekta, B. G. (2025) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000842 · Cited by 1
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Erkizia-Santamaría, I., Fernández, L., Horrillo, I., Meana, J. J., & Ortega, J. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.11.30.691402
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Liu, J., Bulin, S. E., & Morilak, D. A. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03380-8 · Cited by 1
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Sharma, A. N. (2011) · OhioLink ETD Center (Ohio Library and Information Network)
Shanker, S., Saroj, N., Manjarrez‐Gutiérrez, G., López-Sánchez, P., & Terrón, J. A. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150233
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Hu, K., Wang, X., Yu, W., Liu, Q., Cheng, Y., Song, Y., Liang, L., Liu, W., Zhang, J., Chang, S., et al. (2026) · Current Drug Targets · doi:10.2174/0113894501438555260211105139
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Tchenio, A. (2017) · theses.fr (ABES) · doi:10.70675/981419c3z06f5z440dz9e73ze1d620709914
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Becker, L. J. (2021) · theses.fr (ABES) · doi:10.70675/cdeda10fz3bbdz4a8cza740z361352fc379b
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Carmon, A., Hilber, P., Castel, H., & Dubois, M. (2026) · Contemporary clinical neuroscience · doi:10.1007/978-3-032-18296-8_9
Pitcairn, S. R., Tapp, A. E., Drenan, R. M., & Weiner, J. L. (2026) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2026.1771722
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Abdallah, K., & Yalçın, İ. (2025) · Dunod eBooks · doi:10.3917/dunod.poisb.2025.01.0841
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Gündoğdu, E. D., & ÖZAÇMAK, H. S. (2026) · Brain Research · doi:10.1016/j.brainres.2026.150512
Rod, A. (2014) · NORA - Norwegian Open Research Archives
Metadata
- Authors
- Katz, R. J.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Katz, Richard J.
- ORCID
- Katz, Richard J.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1982-06
- Volume
- 16
- Issue
- 6
- Pages
- 965-968
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2099660163
- Cited by
- 480
- References
- 7
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 21 · 2023: 22 · 2022: 16 · 2021: 20 · 2020: 22 · 2019: 20 · 2018: 20 · 2017: 17 · 2016: 16 · 2015: 11 · 2014: 26 · 2013: 15 · 2012: 18
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- animal models of depression, chronic stress, sucrose intake, imipramine, antidepressant sensitivity, anorexia, mood disorders
- MeSH terms
- Animals, Depressive Disorder, Disease Models, Animal, Drinking, Eating, Humans, Imipramine, Male, Motivation, Rats, Inbred Strains, Stress, Physiological, Rats
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