The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Opiate antagonists stimulate affiliative behaviour in monkeys
Abstract
The effects of treating captive talapoin monkeys acutely (twice daily for 7 days) with naltrexone hydrochloride (0.25 mg 0.5 mg and 1 mg/kg intramuscular injections twice daily), naloxone hydrochloride (0.5 mg/kg IM twice daily) and sulpiride (1.5 mg/kg IM twice daily) was studied in social pairs and singly caged animals. The behaviour of social pairs and endocrine changes in all treated monkeys were monitored before, during and after withdrawal of the course of drug treatment. Naltrexone and naloxone, but not sulpiride, significant increased grooming and grooming invitations while aggressive behaviour, self grooming, scratching and general locomotor activity were unaffected. There was an overall increase in LH, testosterone and cortisol in plasma samples taken 60 mins after opiate receptor blockade. Prolactin was unchanged but increased dramatically in animals treated with sulpiride. No significant endocrine changes were observed to precede the increased grooming behaviour which opiate receptor blockade induced. The behavioural changes reported for this primate support the view that positive affect arising from social bonds may be mediated by cerebral endorphin containing systems.
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“opioid agonists, such as morphine, decrease physical contact between social partners, whereas NAL administration increases solicitation for social contact, such as grooming and proximity (16–19).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [17]
In the citing paper
“The μ -opioid receptor (16) has been of particular interest because it is the target of β -endorphin, which seems to play an important role in maintaining social bonds in primates (including humans) (17 -19).”
From Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality (2017) · cites this paper as [17]
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“Opiates depress testosterone in both rats (Cicero er aL, 1976) and the human (Mendelson et aL, 1975), and in this study, as in studies on talapoin monkeys ( Fabre-Nys et al., 1982; Meller er al., 1980), opiate antagonists elevated testosterone.”
BackgroundResultSocial influences on behaviour and neuroendocrine responsiveness of talapoin monkeys
Keverne, E. B., Meller, R. E., & EBERHART, J. A. (1982) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.1982.tb00450.x · Cited by 13
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“58,59 This suggests that mu-opioid receptors help establish and reinforce affiliative relationships through physical interaction.”
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“and the receiver ( Fabre-Nys et al. 1982; Boccia 1987; Boccia et al. 1989; Keverne et al. 1989; Shutt et al. 2007).”
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“, 1995), grooming solicitations in adult primates (Fabre-Nys et al., 1982; Martel et al., 1995) and tail-wagging in dogs (a behaviour that serves to maintain group cohesion) (Knowles et al.”
BackgroundThe Neurochemical Basis of Motivation for Affiliative Touch
Løseth, G. E., Leknes, S., & Ellingsen, D. (2016) · Springer eBooks · doi:10.1007/978-1-4939-6418-5_15 · Cited by 5
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Dunbar, R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/354068 · Cited by 4
“…grooming is the central engine in building relationships for primates: grooming triggers the release of endorphins in the brain in both primates (Fabre-Nys et al. 1982; Keverne et al. 1989; Martel et al. 1993) and humans (Nummenmaa et al. 2016), and endorphins are central to the creation and…”
BackgroundSex Differences in Primate Social Behavior
Keverne, E. B. (1993) · Springer eBooks · doi:10.1007/978-94-011-1709-8_13 · Cited by 4
Oxytocin and opioid antagonists: A dual approach to improving social behavior
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“151,152 OT also influences social behaviors, typically enhancing attention to social stimuli and promoting prosocial choices.”
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Chen, J., Putkinen, V., Seppälä, K., Hirvonen, J., Ioumpa, K., Gazzola, V., Keysers, C., & Nummenmaa, L. (2024) · Communications Biology · doi:10.1038/s42003-024-07084-7 · Cited by 3
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“Data from both nonhuman primates (23-25) and humans suggest that the endogenous opioid system and particularly the mu-opioid receptors (MORs) support multitude of prosocial functions including social bonding and attachment (26-29) and empathy (30, 31).”
BackgroundAdult Social Relationships in Primates
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Kimble, V. M. (2026) · Oxford Open Neuroscience · doi:10.1093/oons/kvag009
Buehler, R., Ulrich Ansorge, A., Willeit, M., & Silani, G. (2026) · Research Square · doi:10.21203/rs.3.rs-10805669/v1
Metadata
- Authors
- Fabre-Nys, C., Meller, R. E., & Keverne, E. B.
- Affiliations
- University of Cambridge (GB)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1982-04
- Volume
- 16
- Issue
- 4
- Pages
- 653-659
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2083065545
- Cited by
- 141
- References
- 38
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 13 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- opioid antagonists, naltrexone, naloxone, sulpiride, affiliative behavior, grooming, social bonds, endorphin system, luteinizing hormone, testosterone, cortisol, prolactin, primate social behavior
- MeSH terms
- Animals, Behavior, Animal, Cercopithecidae, Eating, Female, Grooming, Hydrocortisone, Luteinizing Hormone, Male, Motor Activity, Naloxone, Naltrexone, Prolactin, Receptors, Opioid, Social Behavior, Stimulation, Chemical, Sulpiride, Testosterone
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