Cited by 141Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

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Opiate antagonists stimulate affiliative behaviour in monkeys

Fabre-Nys, Claude, Meller, Rachael E., Keverne, E.B.·1982·Pharmacology Biochemistry and Behavior

DOI 10.1016/0091-3057(82)90432-4

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Abstract

The effects of treating captive talapoin monkeys acutely (twice daily for 7 days) with naltrexone hydrochloride (0.25 mg 0.5 mg and 1 mg/kg intramuscular injections twice daily), naloxone hydrochloride (0.5 mg/kg IM twice daily) and sulpiride (1.5 mg/kg IM twice daily) was studied in social pairs and singly caged animals. The behaviour of social pairs and endocrine changes in all treated monkeys were monitored before, during and after withdrawal of the course of drug treatment. Naltrexone and naloxone, but not sulpiride, significant increased grooming and grooming invitations while aggressive behaviour, self grooming, scratching and general locomotor activity were unaffected. There was an overall increase in LH, testosterone and cortisol in plasma samples taken 60 mins after opiate receptor blockade. Prolactin was unchanged but increased dramatically in animals treated with sulpiride. No significant endocrine changes were observed to precede the increased grooming behaviour which opiate receptor blockade induced. The behavioural changes reported for this primate support the view that positive affect arising from social bonds may be mediated by cerebral endorphin containing systems.

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Neurobiology of Affiliative Behavior in Nonhuman Primates**Partial support for this research has been obtained from the Research Council, Rutgers University; Veterans Administration Research funds; the Harry Frank Guggenheim Foundation, New York; and The Epilepsy Foundation of America. We thank Dr. M.J. Raleigh for commenting on an earlier version of this chapter and Ms. Sylva Grossman for typing the manuscript.
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“Furthermore, in Rhesus macaques, acute administration of an opiate antagonist increases maternal and affiliative behavior, while morphine decreases these behaviors (Fabre-Nys et al., 1982, Kalin et al., 1988, Martel et al., 1993).”
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“For instance, in non-human primates, the opioid antagonist naltrexone increases social motivation while decreasing sexual motivation [25,26], while in humans opioid agonists lead to increased social motivation [27].”
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Authors: Fabre-Nys, C., Meller, R. E., & Keverne, E. B.
Affiliations: University of Cambridge (GB)
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 1982-04
Volume: 16
Issue: 4
Pages: 653-659
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/0091-3057(82)90432-4
OpenAlex: W2083065545
Cited by: 141
References: 38
Citations by year: 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 13 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 4
FWCI: 6.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: opioid antagonists, naltrexone, naloxone, sulpiride, affiliative behavior, grooming, social bonds, endorphin system, luteinizing hormone, testosterone, cortisol, prolactin, primate social behavior
MeSH terms: Animals, Behavior, Animal, Cercopithecidae, Eating, Female, Grooming, Hydrocortisone, Luteinizing Hormone, Male, Motor Activity, Naloxone, Naltrexone, Prolactin, Receptors, Opioid, Social Behavior, Stimulation, Chemical, Sulpiride, Testosterone

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Opiate antagonists stimulate affiliative behaviour in monkeys

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