The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Opiate antagonists stimulate affiliative behaviour in monkeys
Abstract
The effects of treating captive talapoin monkeys acutely (twice daily for 7 days) with naltrexone hydrochloride (0.25 mg 0.5 mg and 1 mg/kg intramuscular injections twice daily), naloxone hydrochloride (0.5 mg/kg IM twice daily) and sulpiride (1.5 mg/kg IM twice daily) was studied in social pairs and singly caged animals. The behaviour of social pairs and endocrine changes in all treated monkeys were monitored before, during and after withdrawal of the course of drug treatment. Naltrexone and naloxone, but not sulpiride, significant increased grooming and grooming invitations while aggressive behaviour, self grooming, scratching and general locomotor activity were unaffected. There was an overall increase in LH, testosterone and cortisol in plasma samples taken 60 mins after opiate receptor blockade. Prolactin was unchanged but increased dramatically in animals treated with sulpiride. No significant endocrine changes were observed to precede the increased grooming behaviour which opiate receptor blockade induced. The behavioural changes reported for this primate support the view that positive affect arising from social bonds may be mediated by cerebral endorphin containing systems.
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“opioid agonists, such as morphine, decrease physical contact between social partners, whereas NAL administration increases solicitation for social contact, such as grooming and proximity (16–19).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [17]
In the citing paper
“The μ -opioid receptor (16) has been of particular interest because it is the target of β -endorphin, which seems to play an important role in maintaining social bonds in primates (including humans) (17 -19).”
From Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality (2017) · cites this paper as [17]
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“This is further supported by the finding that endogenous opiate withdrawal by receptor blockade with naltrexone enhances the need for social attachment (Meller et al., 1980; Fabre-Nys et al., 1982).”
BackgroundThe compulsion to repeat the trauma. Re-enactment, revictimization, and masochism.
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Metadata
- Authors
- Fabre-Nys, C., Meller, R. E., & Keverne, E. B.
- Affiliations
- University of Cambridge (GB)
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1982-04
- Volume
- 16
- Issue
- 4
- Pages
- 653-659
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2083065545
- Cited by
- 141
- References
- 38
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 6 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 13 · 2016: 7 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 4
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- opioid antagonists, naltrexone, naloxone, sulpiride, affiliative behavior, grooming, social bonds, endorphin system, luteinizing hormone, testosterone, cortisol, prolactin, primate social behavior
- MeSH terms
- Animals, Behavior, Animal, Cercopithecidae, Eating, Female, Grooming, Hydrocortisone, Luteinizing Hormone, Male, Motor Activity, Naloxone, Naltrexone, Prolactin, Receptors, Opioid, Social Behavior, Stimulation, Chemical, Sulpiride, Testosterone
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