Locomotor effects of cocaine, cocaine congeners, and local anesthetics in mice
Abstract
Spontaneous locomotor activity of mice was stimulated by IP administration of cocaine and its closely related phenyltropane analogs. In contrast, locomotion was inhibited by IP administration of cocaine congeners such as norcocaine, (+)-pseudococaine, and tropacocaine, and of isomers of phenyltropane analogs. Also inhibitory were the local anesthetics procaine, tetracaine, benzocaine, lidocaine, and prilocaine. The locomotor inhibition induced by IP norcocaine or tetracaine could be reversed by subsequent treatment with cocaine. Both cocaine and norcocaine were centrally stimulatory when injected intracerebroventricularly. The rank order of potencies of cocaine congeners and local anesthetics in depressing locomotion was similar to that of their potencies in interacting with sodium channels. From these results we infer that the locomotor depression induced by systemic administration of cocaine congeners results from a local anesthetic action involving inhibition of the ion conductance of sodium channels.
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Intraperitoneal administration of procaine induces conditioned place preference and does not increase but instead decreases forward locomotion.
“Interestingly, intraperitoneal administration of procaine, which induces conditioned place preference, does not increase but instead decreases forward locomotion (Wiechman et al., 1981; Reith et al., 1985).”
From Dopamine reward circuitry: Two projection systems from the ventral midbrain to the nucleus accumbens–olfactory tubercle complex (2007) · cites this paper as Reith et al., 1985
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Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
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- Authors
- Reith, M. E. A., Meisler, B. E., & Lajtha, A.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- ORCID
- Reith, Maarten E.A.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1985-11
- Volume
- 23
- Issue
- 5
- Pages
- 831-836
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2030615926
- Cited by
- 53
- References
- 29
- Citations by year
- 2020: 1 · 2018: 1 · 2016: 1 · 2015: 2
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA03025)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- cocaine, norcocaine, local anesthetics, procaine, tetracaine, benzocaine, lidocaine, prilocaine, locomotor activity, locomotor inhibition, sodium channel blockade, intracerebroventricular administration
- MeSH terms
- Anesthetics, Local, Animals, Cocaine, Dose-Response Relationship, Drug, Drug Interactions, Injections, Intraperitoneal, Injections, Intraventricular, Ion Channels, Male, Mice, Inbred BALB C, Motor Activity, Structure-Activity Relationship, Tetracaine, Mice
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