The DOI matches its Crossref record; 19 of the 21 references it cites were found in a registry or an index.
Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by Rhesus monkeys
Abstract
Rhesus monkeys were surgically prepared with chronic intravenous catheters and allowed to self-administer the indirect dopamine (DA) agonist cocaine (0.03 or 0.1 mg/kg/inj) or the direct D2 agonist piribedil (0.1 or 0.2 mg/kg/inj) on a fixed-ratio 10 schedule of drug delivery during daily 2 hour experimental sessions. When responding was stable, they were injected IV with SCH 23390, a selective D1 antagonist (0.003-0.3 mg/kg, 30 min pre-session) or pimozide, a selective D2 antagonist (0.003-0.3 mg/kg, 2 hours pre-session). Intermediate doses of pimozide generally increased self-administration of cocaine or piribedil, though increases in piribedil self-administration were more reliable. In contrast, intermediate doses of SCH 23390 either did not affect or decreased cocaine and piribedil self-administration. High doses of each antagonist decreased the rate of self-administration of each compound and produced catalepsy. The selective increase in responding maintained by cocaine or piribedil following pimozide pretreatment suggests a role for a D2-like receptor in psychomotor stimulant self-administration.
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“D2R is also necessary for reward and incentive learning, as well as maintenance of reward- and incentive-related responding, and rats will readily self-administer drugs that activate these receptors (Woolverton et al 1984; Sanger 1986; Woolverton 1986; Hoffman et al 1988; for an early review of the roles of D1R and D2R in reward and reinforcement, see Beninger et al 1989).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Woolverton 1986
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Cites
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Drug abuse: hedonic homeostatic dysregulation
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Metadata
- Authors
- Woolverton, W. L.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Woolverton, William L.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1986-03
- Volume
- 24
- Issue
- 3
- Pages
- 531-535
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W1977382144
- Cited by
- 181
- References
- 21
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2018: 2 · 2016: 6 · 2015: 1 · 2014: 7 · 2013: 7 · 2012: 3
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Massachusetts Department of Agricultural Resources
- National Institute on Drug Abuse (DA00250)
- Janssen Pharmaceuticals
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- cocaine self-administration, piribedil, dopamine D1 receptor, dopamine D2 receptor, dopamine antagonists, pimozide, SCH 23390, psychostimulants, rhesus monkeys, catalepsy, fixed-ratio schedules
- MeSH terms
- Animals, Benzazepines, Cocaine, Drug Interactions, Female, Macaca mulatta, Male, Pimozide, Piperazines, Piribedil, Receptors, Dopamine, Self Administration, Antipsychotic Agents
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