Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide, but not with the noradrenergic blockers phentolamine or phenoxybenzamine.

Antipsychotic Drugs: Direct Correlation Between Clinical Potency and Presynaptic Action on Dopamine Neurons

Seeman, P., & Lee, T. (1975) · Science · doi:10.1126/science.1145194 · Cited by 869 · see citing works

Dopamine Receptors in the Brain

Iversen, L. L. (1975) · Science · doi:10.1126/science.2976 · Cited by 530 · see citing works

Studies on the distinction between uptake inhibition and release of [3H]dopamine in rat brain tissue slices

Heikkila, R. E., Orlansky, H., & Cohen, G. (1975) · Biochemical Pharmacology · doi:10.1016/0006-2952(75)90152-5 · Cited by 468 · see citing works

COCAINE-REINFORCED BEHAVIOR IN RATS: EFFECTS OF REINFORCEMENT MAGNITUDE AND FIXED-RATIO SIZE

Pickens, R. W., & Thompson, T. (1968) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27954-x · Cited by 427 · see citing works

Self-injection of apomorphine in the rat: Positive reinforcement by a dopamine receptor stimulant

Baxter, B. L., Gluckman, M. I., Stein, L., & Scerni, R. A. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90085-9 · Cited by 146 · see citing works

Role of noradrenergic and dopaminergic processes in amphetamine self-administration

Risner, M. E., & Jones, B. E. (1976) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(76)90113-1 · Cited by 142 · see citing works

Aminergic influences on intravenous cocaine self-administration by rhesus monkeys

Wilson, M. C., & Schuster, C. R. (1974) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(74)90021-5 · Cited by 80 · see citing works

Blockade by pimozide of a noradrenaline sensitive adenylate cyclase in the limbic forebrain: possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics

Blumberg, J. B., Taylor, R. E., & Sulser, F. (1975) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1975.tb09420.x · Cited by 70 · see citing works

Chemical Interactions in Methamphetamine Reinforcement

Pickens, R. W., Meisch, R. A., & Dougherty, J. A. (1968) · Psychological Reports · doi:10.2466/pr0.1968.23.3f.1267 · Cited by 65 · see citing works

FIXED‐INTERVAL SCHEDULES OF INTRAVENOUS COCAINE PRESENTATION IN RATS1

Dougherty, J. A., & Pickens, R. W. (1973) · Journal of the Experimental Analysis of Behavior · doi:10.1901/jeab.1973.20-111 · Cited by 45 · see citing works

What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?

Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works

Dopamine, learning and motivation.

Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works

Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine

Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works

Drugs of abuse: anatomy, pharmacology and function of reward pathways

Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works

Acute effects of cocaine on human brain activity and emotion

Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270 · see citing works

Dopamine in drug abuse and addiction: results from imaging studies and treatment implications

Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101 · see citing works

Decreased dopamine D₂ receptor availability is associated with reduced frontal metabolism in cocaine abusers

Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works

The role of dopamine in locomotor activity and learning

Beninger, R. J. (1983) · Brain Research Reviews · doi:10.1016/0165-0173(83)90038-3 · Cited by 848 · see citing works

Neurobiological similarities in depression and drug dependence: a self-medication hypothesis

Markou, A. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00113-9 · Cited by 767 · see citing works

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730 · see citing works

Drug-activation of brain reward pathways

Wise, R. A. (1998) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(98)00063-5 · Cited by 684 · see citing works

Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines

Morón, J. A., Brockington, A., Wise, R. A., Rocha, B. A., & Hope, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00389.2002 · Cited by 681 · see citing works

Dopamine, schizophrenia, mania, and depression: Toward a unified hypothesis of cortico-striatopallido-thalamic function

Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674 · see citing works

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F. (1984) · Psychopharmacology · doi:10.1007/bf00427441 · Cited by 651 · see citing works

New concepts in cocaine addiction: The dopamine depletion hypothesis

Dackis, C. A., & Gold, M. S. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90022-3 · Cited by 607 · see citing works

Dopamine and reward: The anhedonia hypothesis 30 years on

Wise, R. A. (2008) · Neurotoxicity Research · doi:10.1007/bf03033808 · Cited by 580 · see citing works

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

Ettenberg, A., Pettit, H. O., Bloom, F. E., & Koob, G. F. (1982) · Psychopharmacology · doi:10.1007/bf00428151 · Cited by 563 · see citing works

Role of dopamine, the frontal cortex and memory circuits in drug addiction: insight from imaging studies

Volkow, N. (2002) · Neurobiology of Learning and Memory · doi:10.1006/nlme.2002.4099 · Cited by 514 · see citing works

Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

Roberts, D. C. S., & Koob, G. F. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90469-5 · Cited by 448 · see citing works

Effects of chronic cocaine abuse on postsynaptic dopamine receptors

(1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.6.719 · Cited by 421 · see citing works

Prediction of Reinforcing Responses to Psychostimulants in Humans by Brain Dopamine D₂ Receptor Levels

Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Gifford, A., Hitzemann, R., Ding, Y.-S., & Pappas, N. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.9.1440 · Cited by 406 · see citing works

Role of dopamine in drug reinforcement and addiction in humans: results from imaging studies

Volkow, N. D., Fowler, J. S., & Wang, G.-J. (2002) · Behavioural Pharmacology · doi:10.1097/00008877-200209000-00008 · Cited by 398 · see citing works

Involvement of cAMP-dependent protein kinase in the nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior

Self, D. W., Genova, L. M., Hope, B. T., Barnhart, W. J., Spencer, J. J., & Nestler, E. J. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-05-01848.1998 · Cited by 325 · see citing works

Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings

Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works

Dopamine D₃Receptor Antagonism Inhibits Cocaine-Seeking and Cocaine-Enhanced Brain Reward in Rats

Vorel, S. R., Ashby, C. R., Paul, M., Liu, X., Hayes, R., Hagan, J. J., Middlemiss, D. N., Stemp, G., & Gardner, E. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09595.2002 · Cited by 269 · see citing works

Progression of changes in dopamine transporter binding site density as a result of cocaine self-administration in rhesus monkeys

Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239 · see citing works

Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists

Caine, S. B., Negus, S. S., Mello, N. K., Patel, S., Bristow, L., Kulagowski, J., Vallone, D., Saiardi, A., & Borrelli, E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02977.2002 · Cited by 234 · see citing works

The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat

Hubner, C. B., & Koob, G. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91112-t · Cited by 218 · see citing works

Opponent Process Model and Psychostimulant Addiction

Koob, G. F., Caine, S. B., Parsons, L., Markou, A., & Weiss, F. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00438-8 · Cited by 196 · see citing works

Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse

Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193 · see citing works

Amphetamine-type reinforcement by dopaminergic agonists in the rat

Yokel, R. A., & Wise, R. A. (1978) · Psychopharmacology · doi:10.1007/bf00427393 · Cited by 181 · see citing works

Effects of a D1 and a D2 dopamine antagonist on the self-administration of cocaine and piribedil by Rhesus monkeys

Woolverton, W. L. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90553-8 · Cited by 181 · see citing works

Habit-forming actions of nomifensine in nucleus accumbens

Carlezon, W. A., Devine, D. P., & Wise, R. A. (1995) · Psychopharmacology · doi:10.1007/bf02246095 · Cited by 170 · see citing works

The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food

Woolverton, W. L., & Virus, R. M. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90019-1 · Cited by 129 · see citing works

Blockade of striatal dopamine transporters by intravenous methylphenidate is not sufficient to induce self-reports of “high”

Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Dewey, S. L., Hitzemann, R., Gifford, A. N., & Pappas, N. R. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37918-2 · Cited by 125 · see citing works

Cocaine uptake is decreased in the brain of detoxified cocaine abusers

Volkow, N. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00073-m · Cited by 120 · see citing works

Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

Phillips, G. D., Robbins, T. W., & Everitt, B. J. (1994) · Psychopharmacology · doi:10.1007/bf02249339 · Cited by 116 · see citing works

Sex differences in behavioral and neural cross-sensitization and escalated cocaine taking as a result of episodic social defeat stress in rats

Holly, E. N., Shimamoto, A., DeBold, J. F., & Miczek, K. A. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2846-2 · Cited by 98 · see citing works

Intravenous cocaine-induced place preference: attenuation by haloperidol

Spyraki, C., Nomikos, G. G., & Varonos, D. D. (1987) · Behavioural Brain Research · doi:10.1016/0166-4328(87)90016-7 · Cited by 87 · see citing works

Acetylcholine release in the mesocorticolimbic dopamine system during cocaine seeking: conditioned and unconditioned contributions to reward and motivation

You, Z.-B., Wang, B., Zitzman, D., & Wise, R. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0694-08.2008 · Cited by 71 · see citing works

Lack of effect of acute dopamine precursor depletion in nicotine-dependent smokers

Casey, K. F., Benkelfat, C., Young, S. N., & Leyton, M. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2006.02.002 · Cited by 54 · see citing works

New perspectives on cocaine addiction: recent findings from animal research

Bozarth, M. A. (1989) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y89-185 · Cited by 47 · see citing works

Chronic cocaine administration reduces striatal dopamine terminal density and striatal dopamine release which leads to drug-seeking behaviour

Lee, J., Parish, C. L., Tomas, D., & Horne, M. K. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2010.11.055 · Cited by 19 · see citing works

Mechanisms involved in the blocking effects of pimozide on smooth muscle contraction

Celuch, S. M., & Enero, M. A. (1983) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(83)90164-7 · Cited by 3 · see citing works

Enhancement of noradrenaline depletion in the cat spleen by phenoxybenzamine and phentolamine

Cripps, H., Dearnaley, D. P., & Howe, P. R. C. (1972) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1972.tb06883.x · Cited by 8 · see citing works

The effect of two alpha-receptor blocking agents on skin-flap survival in rats

Wexler, M. R., Yeshua, R., & Neuman, Z. (1974) · European Journal of Plastic Surgery · doi:10.1007/bf00276612 · Cited by 3 · see citing works

PROTECTION BY PHENTOLAMINE AGAINST THE EFFECTS OF PHENOXYBENZAMINE ON TRANSMITTER RELEASE ELICITED BY NERVE STIMULATION IN THE PERFUSED CAT HEART

Farah, M. B., & Langer, S. Z. (1974) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1974.tb09723.x · Cited by 37 · see citing works

Interaction of OC and β-Adrenoceptor Blocking Agents in the Conscious Rat

Oates, H. F. (1979) · Clinical and Experimental Hypertension · doi:10.3109/10641967909068633