Cited by 448Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeuroscience and Neuropharmacology Research

Disruption of cocaine self-administration following 6-hydroxydopamine lesions of the ventral tegmental area in rats

Roberts, David C.S., Koob, George F.·1982·Pharmacology Biochemistry and Behavior

Abstract

6-Hydroxydopamine-induced destruction of dopaminergic terminals in the nucleus accumbens have been shown previously to disrupt cocaine and amphetamine self-administration. We sought to determine whether lesions of the DA cell bodies in the ventral tegmental area (VTA) which give rise to the DA innervation of the n. accumbens, would also disrupt cocaine self-administration behavior. Rats were trained to self-inject cocaine (0.75 mg/kg) for 4 hr/day. After a stable baseline was established, one group of rats received bilateral injections of 6-OHDA (4 micrograms/l microliter) into the VTA. Control rats received vehicle injections. When retested on the fifth day post-lesion, all of the 6-OHDA treated animals showed a long lasting reduction in cocaine intake. Three animals did not reinitiate cocaine self-administration after the lesion, although each showed stable post-lesion responding for apomorphine. The surgery had no effect on cocaine self-administration in control animals. These data support the hypothesis that dopaminergic mechanisms are necessary for the normal expression of cocaine self-administration.

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Crossref · 10.1016/0091-3057(82)90469-5

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Authors
Roberts, D. C. S., & Koob, G. F.
Affiliations
  • Carleton University (CA)
  • Salk Institute for Biological Studies (US)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1982-11
Volume
17
Issue
5
Pages
901-904
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2077153133
Cited by
448
References
20
Citations by year
2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 7 · 2019: 5 · 2018: 8 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 7 · 2013: 14 · 2012: 9
FWCI
2.25
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
cocaine self-administration, ventral tegmental area, 6-hydroxydopamine lesion, dopaminergic neurons, nucleus accumbens, dopamine, amphetamine self-administration, apomorphine
MeSH terms
Animals, Cocaine, Conditioning, Operant, Dopamine, Hydroxydopamines, Limbic System, Male, Nucleus Accumbens, Rats, Inbred Strains, Receptors, Cholinergic, Receptors, Dopamine, Self Administration, Tegmentum Mesencephali, Oxidopamine, Rats

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