Cited by 69Alzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesNeurological Disease Mechanisms and Treatments

Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats

Bensimon, G., Chermat, R.·1991·Pharmacology Biochemistry and Behavior

Abstract

Neuropathological findings in Alzheimer's disease (AD) suggest a possible involvement of microtubule dysfunction in neurodegenerative process pathogenesis. Because microtubules have a major role in neuronal plasticity, microtubule disruption could be also directly responsible for cognitive defects in AD. We report that in rats, continuous microtubule disruption induced by chronic colchicine administration results in a dose-dependent learning deficit. In addition, retention is also impaired. These cognitive defects are specific, as chronic colchicine induces no other behavioral toxicity within the study dose range. Colchicine-induced cognitive defects resemble those of AD, which are characterised by amnesia of recent learning and loss of formerly established memories. This new procedure of pharmacologically induced cognitive impairment may prove useful, both towards understanding AD pathogenesis and towards drug screening.

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Crossref · 10.1016/0091-3057(91)90602-x

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37 of 37 references verified0 citation errors · 0 not checkable

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  • Colchicine infused directly into the brains of animals causes severe cognitive impairment and apparent loss of consciousness.

    “Colchicine infused directly into the brains of animals does cause severe cognitive impairment and apparent loss of consciousness [154].”

    From Consciousness in the universe (2014) · cites this paper as [154]

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Authors
Bensimon, G., & Chermat, R.
Affiliations
Pitié-Salpêtrière Hospital (FR)
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
1991-01
Volume
38
Issue
1
Pages
141-145
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2012713745
Cited by
69
References
38
Citations by year
2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 4
FWCI
1.24
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
microtubule disruption, colchicine, Alzheimer's disease, learning deficits, memory impairment, cognitive impairment, neuroplasticity, drug screening
MeSH terms
Animals, Behavior, Animal, Cognition, Colchicine, Conditioning, Operant, Dose-Response Relationship, Drug, Learning, Lumicolchicines, Male, Memory, Microtubules, Motor Activity, Rats, Inbred Strains, Rats

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