Microtubule disruption and cognitive defects: Effect of colchicine on learning behavior in rats
Abstract
Neuropathological findings in Alzheimer's disease (AD) suggest a possible involvement of microtubule dysfunction in neurodegenerative process pathogenesis. Because microtubules have a major role in neuronal plasticity, microtubule disruption could be also directly responsible for cognitive defects in AD. We report that in rats, continuous microtubule disruption induced by chronic colchicine administration results in a dose-dependent learning deficit. In addition, retention is also impaired. These cognitive defects are specific, as chronic colchicine induces no other behavioral toxicity within the study dose range. Colchicine-induced cognitive defects resemble those of AD, which are characterised by amnesia of recent learning and loss of formerly established memories. This new procedure of pharmacologically induced cognitive impairment may prove useful, both towards understanding AD pathogenesis and towards drug screening.
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Colchicine infused directly into the brains of animals causes severe cognitive impairment and apparent loss of consciousness.
“Colchicine infused directly into the brains of animals does cause severe cognitive impairment and apparent loss of consciousness [154].”
From Consciousness in the universe (2014) · cites this paper as [154]
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- Authors
- Bensimon, G., & Chermat, R.
- Affiliations
- Pitié-Salpêtrière Hospital (FR)
- ORCID
- Bensimon, G.
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 1991-01
- Volume
- 38
- Issue
- 1
- Pages
- 141-145
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2012713745
- Cited by
- 69
- References
- 38
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 3 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- microtubule disruption, colchicine, Alzheimer's disease, learning deficits, memory impairment, cognitive impairment, neuroplasticity, drug screening
- MeSH terms
- Animals, Behavior, Animal, Cognition, Colchicine, Conditioning, Operant, Dose-Response Relationship, Drug, Learning, Lumicolchicines, Male, Memory, Microtubules, Motor Activity, Rats, Inbred Strains, Rats
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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