Neuroprotective effects of Bacopa monnieri in experimental model of dementia
Abstract
Alzheimer disease (AD) is characterized by dementia that begins as mild short term memory deficit and culminates in total loss of cognitive and executive functions. The present study was conducted to evaluate the neuroprotective potential of Bacopa monnieri (BM), an Indian traditional medicinal plant effective against cognitive impairment, in colchicine-induced dementia. Intracerebroventricular administration of colchicine (15 μg/5 μl) induced cognitive impairment in rats as assessed by elevated plus maze. This was accompanied by a significant increase in oxidative stress in term of enhanced levels of lipid peroxidation and protein carbonyls. Concomitantly, decrease in activity of antioxidant enzymes was observed in colchicine treated animals. BM (50 mg/kg body weight) supplementation reversed memory impairment observed in the colchicine treated rats. BM administration attenuated oxidative damage, as evident by decreased LPO and protein carbonyl levels and restoration in activities of the antioxidant enzymes. The activity of membrane bound enzymes (Na(+)K(+) ATPase and AChE) was altered in colchicine treated brain regions and BM supplementation was able to restore the activity of enzymes to comparable values observed in controls. The results suggest therapeutic potential of BM in the treatment of AD associated cognitive decline.
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Bacopa monnieri supplementation improves Alzheimer's like characteristics in mouse models, such as colchicine treatment, olfactory bulbectomy, and APP(SWE) expressing mice.
“and improves the Alzheimer’s like characteristics in mouse models, such as colchicine treatment,13 olfactory bulbectomy,14 and APP(SWE) expressing mice.14”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [13]
B. monnieri's ability to protect mitochondria from ROS insult may explain why studies have shown positive behavioral changes in Alzheimer's experimental models but no change in size of plaques, even when amyloid β load is reduced.
“B.monnieri’s ability to protect the mitochondria from ROS insult may explain why studies have shown positive behavioral changes in Alzheimer’s experimental models but no change in the size of plaques, even when amyloid β load is reduced.13”
From Bacopa monnieri (L.) wettst. Extract protects against glutamate toxicity and increases the longevity of Caenorhabditis elegans (2020) · cites this paper as [13]
Bacopa at a dose of 50 mg/kg demonstrated a neuroprotective effect in the colchicine model of dementia through its antioxidant effect and restored the activity of Na+K+ATPase and AChE.
“Bacopa, at the dose of 50 mg/kg, demonstrated the neuroprotective effect in the colchicine model of dementia through its antioxidant effect and restored the activity of Na+K+ATPase and AChE [85].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [85]
Bacopa monnieri extracts attenuated oxidative damage caused by colchicine via reduction in protein carbonyl content while restoring antioxidant enzyme activity.
“Similarly, B. monnieri extracts attenuated oxidative damage caused by colchicine via the reduction in the protein carbonyl content while also restoring antioxidant enzyme activity [105].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [105]
Bacopa monnieri extracts backtracked colchine-induced cognitive impairments.
“Another conducted study demonstrated the backtracking of colchine-induced cognitive impairments by B. monnieri extracts [105].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [105]
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- Authors
- Saini, N., Singh, D., & Sandhir, R.
- Affiliations
- Panjab University (IN)
- Punjabi University (IN)
- Corresponding author
- Sandhir, Rajat
- ORCID
- Sandhir, Rajat
- Venue
- Neurochemical Research
- Published
- 2012-06-15
- Volume
- 37
- Issue
- 9
- Pages
- 1928-1937
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W1987953841
- Semantic Scholar
- 9804c3dfdd7047b413e81faf3be80e88cff4e2fa
- Cited by
- 95
- References
- 90
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 4 · 2017: 3 · 2016: 7 · 2015: 1 · 2014: 7 · 2013: 7 · 2012: 2
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Bacopa monnieri, Alzheimer's disease, dementia, neuroprotection, oxidative stress, lipid peroxidation, protein carbonyls, antioxidant enzymes, memory impairment, Na+/K+-ATPase, acetylcholinesterase, traditional medicinal plants
- MeSH terms
- Acetylcholinesterase, Sodium-Potassium-Exchanging ATPase, Animals, Antioxidants, Anxiety, Behavior, Animal, Brain Chemistry, Cognition Disorders, Colchicine, Dementia, Postural Balance, Glutathione, Male, Plant Extracts, Psychomotor Performance, Suspensions, Synaptosomes, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Neuroprotective Agents, Bacopa, Protein Carbonylation, Rats
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