Cited by 553Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchCholinesterase and Neurodegenerative Diseases

Alzheimer's disease

Wilcock, G.K., Esiri, M.M., Bowen, D.M., Smith, C.C.T.·1982·Journal of the Neurological Sciences

Abstract

We have examined the choline acetyltransferase [CAT] activity in autopsy samples of frontal and temporal lobe cortex from 47 patients (31 with Alzheimer's disease, 4 with dementia due to cerebrovascular disease and 12 undemented controls) and compared it with the severity of dementia during life and with the numbers of argyrophilic plaques and neurofibrillary tangles in the corresponding areas of cortex in the contralateral cerebral hemisphere. CAT activity was significantly reduced, most severely in the temporal lobe, in patients with Alzheimer's disease but not in patients with a cerebrovascular cause for their dementia, and CAT activity showed no significant reduction with age in the undemented control patients. In the patients with Alzheimer's disease the reduction in CAT activity was significantly correlated with the severity of dementia and with the numbers of neurofibrillary tangles, but not argyrophilic plaques, present in the corresponding contralateral cortex.

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Crossref · 10.1016/0022-510x(82)90045-4

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20 of 20 references verified0 citation errors · 0 not checkable

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Authors
Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Smith, C. C. T.
Affiliations
  • University of Oxford (GB)
  • National Hospital for Neurology and Neurosurgery (GB)
Venue
Journal of the Neurological Sciences
Publisher
Elsevier BV
Published
1982-12
Volume
57
Issue
2-3
Pages
407-417
ISSN
0022-510X (ISSN-L)
OpenAlex
W1550759106
Cited by
553
References
20
Citations by year
2026: 3 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 8
FWCI
22.45
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of the Neurological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Keywords
Alzheimer's disease, choline acetyltransferase, temporal cortex, dementia severity, vascular dementia, neurofibrillary tangles, cholinergic dysfunction, age-related enzyme activity
MeSH terms
Aged, Alzheimer Disease, Cerebral Cortex, Choline O-Acetyltransferase, Dementia, Frontal Lobe, Humans, Middle Aged, Neurofibrils, Temporal Lobe

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