Alzheimer's disease
Abstract
We have examined the choline acetyltransferase [CAT] activity in autopsy samples of frontal and temporal lobe cortex from 47 patients (31 with Alzheimer's disease, 4 with dementia due to cerebrovascular disease and 12 undemented controls) and compared it with the severity of dementia during life and with the numbers of argyrophilic plaques and neurofibrillary tangles in the corresponding areas of cortex in the contralateral cerebral hemisphere. CAT activity was significantly reduced, most severely in the temporal lobe, in patients with Alzheimer's disease but not in patients with a cerebrovascular cause for their dementia, and CAT activity showed no significant reduction with age in the undemented control patients. In the patients with Alzheimer's disease the reduction in CAT activity was significantly correlated with the severity of dementia and with the numbers of neurofibrillary tangles, but not argyrophilic plaques, present in the corresponding contralateral cortex.
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Previous studies helped establish the connection between amyloid-beta plaques, neurofibrillary tangles, and antemortem cognitive impairment.
“and previous studies that had also helped to establish the connection between AβPs, NFTs, and antemortem cognitive impairment (311-320).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [320]
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- Authors
- Wilcock, G. K., Esiri, M. M., Bowen, D. M., & Smith, C. C. T.
- Affiliations
- University of Oxford (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Venue
- Journal of the Neurological Sciences
- Publisher
- Elsevier BV
- Published
- 1982-12
- Volume
- 57
- Issue
- 2-3
- Pages
- 407-417
- ISSN
- 0022-510X (ISSN-L)
- OpenAlex
- W1550759106
- Cited by
- 553
- References
- 20
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 7 · 2012: 8
- FWCI
- 22.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the Neurological Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
- Keywords
- Alzheimer's disease, choline acetyltransferase, temporal cortex, dementia severity, vascular dementia, neurofibrillary tangles, cholinergic dysfunction, age-related enzyme activity
- MeSH terms
- Aged, Alzheimer Disease, Cerebral Cortex, Choline O-Acetyltransferase, Dementia, Frontal Lobe, Humans, Middle Aged, Neurofibrils, Temporal Lobe
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