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Orchestrated reduction of quantum coherence in brain microtubules: A model for consciousness
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Neural MTs are identified as the substrate of the quantum conscious process by the Orch OR theory because they appear to offer an ideal candidate medium for intracellular integration and adaptive responding.
“Beyond that, neural MTs are identified as the substrate of the quantum conscious process by the Orch OR theory (Penrose and Hameroff 1995, Hameroff and Penrose 1996, 2014, Hameroff 2021) because they appear to offer an ideal candidate medium for intracellular integration and adaptive responding.”
From A quantum microtubule substrate of consciousness is experimentally supported and solves the binding and epiphenomenalism problems (2025) · cites this paper as Hameroff and Penrose 1996
Penrose and Hameroff responded to Grush and Churchland by explaining that colchicine does not cross the blood brain barrier, so it does not reach the brain, and that brain neurons do not disassemble and reassemble anyway.
“Penrose and Hameroff [12] responded point-by-point to every objection, e.g.explaining that colchicine does not cross the blood brain barrier, and so doesn't reach the brain, and that brain neurons don't disassemble/re-assemble anyway.”
From Consciousness in the universe (2014) · cites this paper as [12]
MTs have been proposed to process information, encode memory, and mediate consciousness.
“MTs have also been proposed to process information, encode memory, and mediate consciousness (S. R. Hameroff et al., 1982; S. Hameroff and Penrose, 1996; S. Hameroff, 2022).”
From Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats (2024) · cites this paper as S. Hameroff and Penrose, 1996
Another class of quantum model understands consciousness in terms of physical vibrational states of MTs in neurons.
“In contrast, another class of quantum model understands consciousness in terms of physical vibrational states of MTs in neurons (S. Hameroff and Penrose, 1996, 2014; Craddock et al., 2017; S. Hameroff, 2022).”
From Microtubule-stabilizer epothilone B delays anesthetic-induced unconsciousness in rats (2024) · cites this paper as S. Hameroff and Penrose, 1996
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McFadden, J. (2021) · NeuroSci · doi:10.3390/neurosci2030021 · Cited by 13
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Mathematical proof of the Fisher-Escolà Q statistical distribution in quantum consciousness modeling
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Quantum-Inspired and Non-Classical Approaches to Consciousness: Models, Evidence and Constraints
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“At the cellular scale, the Orch OR theory posits that quantum-coherent states form within neuronal microtubules and undergo objective reduction, thereby generating discrete conscious moments [42].”
Metadata
- Authors
- Hameroff, S., & Penrose, R.
- Affiliations
- University of Arizona (US)
- University of Oxford (GB)
- Corresponding author
- Hameroff, Stuart
- ORCID
- Hameroff, Stuart
- Venue
- Mathematics and Computers in Simulation
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 40
- Issue
- 3-4
- Pages
- 453-480
- ISSN
- 0378-4754 (ISSN-L)
- OpenAlex
- W2164333417
- Semantic Scholar
- e73054e11d4555f7bbca1cafa1731e2aa494c582
- Cited by
- 641
- References
- 110
- Citations by year
- 2026: 52 · 2025: 62 · 2024: 30 · 2023: 32 · 2022: 31 · 2021: 20 · 2020: 20 · 2019: 30 · 2018: 37 · 2017: 20 · 2016: 20 · 2015: 21 · 2014: 33 · 2013: 35 · 2012: 32
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Mathematics and Computers in Simulation (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Social Sciences › Arts and Humanities › Philosophy › Philosophy and Theoretical Science
- Health Sciences › Medicine › Complementary and alternative medicine › Biofield Effects and Biophysics
- Physical Sciences › Physics and Astronomy › Atomic and Molecular Physics, and Optics › Quantum Mechanics and Applications
- Keywords
- Orchestrated Objective Reduction, consciousness, quantum coherence, microtubules, objective reduction, Penrose, quantum gravity, microtubule-associated proteins, quantum consciousness, spacetime geometry, neuronal activity, synaptic function, brain information processing, quantum superposition, decoherence
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