The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
Open accessAbstract
cDNAs for the bcl-2 mRNA were cloned from a human common acute lymphoblastic leukemia cell line. Nucleotide sequence analyses showed that the 6 kb bcl-2 mRNA potentially encodes a 26 kd protein that is homologous to a predicted Epstein-Barr virus protein. Most t(14;18) translocation breakpoints cluster within a narrow region of a 5.4 kb exon that contains a long 3'-untranslated region of the bcl-2 mRNA. As a result of t(14;18) translocation, hybrid bcl-2/immunoglobulin heavy chain transcripts are produced that consist of the 5' half of the bcl-2 mRNA fused to a "decapitated" immunoglobulin heavy chain mRNA. Nucleotide sequence analyses confirmed that the hybrid transcripts continue to encode a normal bcl-2 protein. Our results suggest that t(14;18) translocations alter expression of the bcl-2 gene both by transcriptional activation and by abnormal posttranscriptional regulation of bcl-2 mRNA.
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Metadata
- Authors
- Cleary, M. L., Smith, S. D., & Sklar, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1986-10
- Volume
- 47
- Issue
- 1
- Pages
- 19-28
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2024582476
- Cited by
- 1,217
- References
- 3
- FWCI
- 25.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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