Cited by 38Medicinal Plants and NeuroprotectionNeurological Disorders and TreatmentsPhytochemicals and Antioxidant Activities

Neuroprotective effect of trans-N-caffeoyltyramine from Lycium chinense against H2O2 induced cytotoxicity in PC12 cells by attenuating oxidative stress

Olatunji, Opeyemi J., Chen, Hongxia, Zhou, Yifeng·2017·Biomedicine & Pharmacotherapy

Abstract

Natural products play a critical role in the promotion of good health as regards the prevention and management of oxidative stress related and neurodegenerative disorders. Oxidative stress has been implicated in several apoptotic pathways associated with cell damages in neuronal disorders. The aim of this study was to investigate the antioxidant effect of trans-N-caffeoyltyramine (TNC) isolated from Cortex lycii against hydrogen peroxide (H 2 O 2) induced cell damages in PC12 cells as well as its mechanism of action. The results obtained indicated that pretreatment with TNC before the exposure of cells to H 2 O 2 toxicity lead to a significant increase in the cell viability and the antioxidant enzyme activities catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and reduced the level of malondialdehyde (MDA). Furthermore, TNC attenuated the influx of Ca 2+, ROS formation and restored the impaired mitochondria membrane potential (MMP). Thus TNC may be used as an alternative therapy for the prevention and treatment of neuronal disorders elicited by oxidative stress.

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Crossref · 10.1016/j.biopha.2017.07.013

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Authors
Olatunji, O. J., Chen, H., & Zhou, Y.
Affiliations
  • Prince of Songkla University (TH)
  • Jiangsu University (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
Zhou, Yifeng
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2017-09
Volume
93
Pages
895-902
ISSN
0753-3322 (ISSN-L)
OpenAlex
W2736089300
Cited by
38
References
38
Citations by year
2026: 1 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 2
FWCI
4.89
Type
journal article
Language
en
Open access
closed
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Public Science and Technology Research Funds Project of Oceans (201505023)
  • Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm (BM2014047)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
Lycium chinense, neuroprotection, oxidative stress, hydrogen peroxide cytotoxicity, PC12 cells, antioxidant enzymes, catalase, superoxide dismutase, glutathione, malondialdehyde, reactive oxygen species, mitochondrial membrane potential, calcium influx, neurodegenerative diseases, natural products
MeSH terms
Animals, Antioxidants, Caffeic Acids, Catalase, Cell Survival, Glutathione, Glutathione Peroxidase, Hydrogen Peroxide, Malondialdehyde, Neurons, Plant Extracts, Superoxide Dismutase, Tyramine, PC12 Cells, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents, Lycium, Cell Line, Tumor, Rats, Membrane Potential, Mitochondrial

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