Cited by 583Hematopoietic Stem Cell TransplantationT-cell and B-cell ImmunologyDevelopmental Biology and Gene Regulation

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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

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Ikuta, Koichi, Kina, Tatsuo, MacNeil, Ian, Uchida, Nobuko, Peault, Bruno, Chien, Yueh-hsiu, Weissman, Irving L.·1990·Cell

DOI 10.1016/0092-8674(90)90262-d

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Abstract

Hematopoietic stem cells (HSCs) isolated from mouse fetal liver, like adult HSCs, are Thy-1lo Lin- Sca-1+. Donor-derived V gamma 3+ T cells were detected in fetal thymic lobes repopulated in vitro with fetal liver HSCs, but not in those with adult bone marrow HSCs. Single clonogenic fetal HSCs gave rise to thymic progeny that include V gamma 3+, other gamma delta+, and alpha beta+ T cells. No V gamma 3+ T cells were detected in adult thymus injected intrathymically with either fetal or adult HSCs. These results support the hypothesis that only fetal HSCs have the capacity to differentiate into V gamma 3+ T cells in the fetal thymic microenvironment and that the developmental potential of HSCs may change during ontogeny.

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Authors: Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y.-H., & Weissman, I. L.
Affiliations: Howard Hughes Medical Institute (US)
Kyoto University (JP)
Stanford Medicine (US)
ORCID: Ikuta, Koichi
Chien, Yueh-hsiu
Weissman, Irving L.
Venue: Cell
Publisher: Elsevier BV
Published: 1990-09
Volume: 62
Issue: 5
Pages: 863-874
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(90)90262-d
OpenAlex: W2008661167
Cited by: 583
References: 51
Citations by year: 2026: 2 · 2025: 6 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 7 · 2020: 17 · 2019: 10 · 2018: 5 · 2017: 9 · 2016: 10 · 2015: 10 · 2014: 9 · 2013: 11 · 2012: 15
FWCI: 21.13
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 5355 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ca042551-13)
National Cancer Institute (CA 42551)
National Institute of Allergy and Infectious Diseases (AI 09072)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: hematopoietic stem cells, fetal liver, γδ T cells, alpha beta T cells, fetal thymus, thymic microenvironment, ontogeny, developmental potential, Sca-1, CD90, clonogenic activity
MeSH terms: Animals, Antibodies, Monoclonal, Antigens, Differentiation, T-Lymphocyte, Base Sequence, Bone Marrow, Cell Differentiation, Cell Division, Colony-Forming Units Assay, Fetus, Flow Cytometry, Hematopoietic Stem Cells, Liver, Mice, Inbred C57BL, Molecular Sequence Data, Organ Culture Techniques, Phenotype, Poly A, Receptors, Antigen, T-Cell, RNA, Messenger, Spleen, T-Lymphocytes, Oligonucleotide Probes, Polymerase Chain Reaction, CD8 Antigens, CD3 Complex, Mice

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A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells

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