Progression of regulatory gene expression states in fetal and adult pro-T-cell development
Open accessAbstract
Summary: Precursors entering the T‐cell developmental pathway traverse a progression of states characterized by distinctive patterns of gene expression. Of particular interest are regulatory genes, which ultimately control the dwell time of cells in each state and establish the mechanisms that propel them forward to subsequent states. Under particular genetic and developmental circumstances, the transitions between these states occur with different timing, and environmental feedbacks may shift the steady‐state accumulations of cells in each state. The fetal transit through pro‐T‐cell stages is faster than in the adult and subject to somewhat different genetic requirements. To explore causes of such variation, this review presents previously unpublished data on differentiation gene activation in pro‐T cells of pre‐T‐cell receptor‐deficient mutant mice and a quantitative comparison of the profiles of transcription factor gene expression in pro‐T‐cell subsets of fetal and adult wildtype mice. Against a background of consistent gene expression, several regulatory genes show marked differences between fetal and adult expression profiles, including those encoding two basic helix‐loop‐helix antagonist Id factors, the Ets family factor SpiB and the Notch target gene Deltex1. The results also reveal global differences in regulatory alterations triggered by the first T‐cell receptor‐dependent selection events in fetal and adult thymopoiesis.
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Gene expression differences have been noted between normal first-wave fetal and adult pro-T cells in the thymus at corresponding stages which indicate that the fetal program drives accelerated development.
“Gene expression differences have been noted between the normal first-wave fetal and adult pro-T cells in the thymus at corresponding stages which indicate that the fetal program drives accelerated development (148, 149).”
From Mechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development (2019) · cites this paper as [148]
Cites
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Self-citationNotch/Delta signaling constrains reengineering of pro-T cells by PU.1
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Self-citationMechanisms of Action of Hematopoietic Transcription Factor PU.1 in Initiation of T-Cell Development
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“Gene expression differences have been noted between the normal first-wave fetal and adult pro-T cells in the thymus at corresponding stages which indicate that the fetal program drives accelerated development (148, 149).”
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- Authors
- David‐Fung, E., Yui, M. A., Morales, M., Wang, H., Taghon, T., Diamond, R. A., & Rothenberg, E. V.
- Affiliations
- California Institute of Technology (US)
- Notre Dame of Maryland University (US)
- Corresponding author
- Rothenberg, Ellen V.
- ORCID
- Venue
- Immunological Reviews
- Publisher
- Wiley
- Published
- 2006-01-31
- Volume
- 209
- Issue
- 1
- Pages
- 212-236
- ISSN
- 0105-2896 (ISSN-L)
- 1600-065X
- PMC
- PMC4157939
- OpenAlex
- W1974305953
- Cited by
- 60
- References
- 14
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Immunological Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- National Institute on Aging (R01AG021588)
- National Cancer Institute (CA98925, R01CA090233, CA90233, R01CA098925)
- National Institute of Allergy and Infectious Diseases (R01AI064590)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- thymopoiesis, T cell differentiation, gene expression regulation, transcription factors, Spi-B, Deltex1, Notch signaling
- MeSH terms
- Aging, Animals, Hematopoietic Stem Cells, Thymus Gland, Transcriptional Activation, T-Lymphocyte Subsets, Gene Expression Regulation, Developmental, Lymphopoiesis, Core Binding Factor alpha Subunits, Proto-Oncogene Proteins c-ets, Mice, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, TCF Transcription Factors
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