Cited by 201Microtubule and mitosis dynamicsNeurobiology and Insect Physiology ResearchDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

Saxton, William M., Hicks, Jennifer, Goldstein, Lawrence S.B., Raff, Elizabeth C.·1991·Cell

DOI 10.1016/0092-8674(91)90264-y

Open this paper in CoChat — free account

Abstract

The in vivo function of the microtubule motor protein kinesin was examined in Drosophila using genetics and immunolocalization. Kinesin heavy chain mutations (khc) cause abnormal behavior and lethality. Mutant larvae exhibit loss of mobility and tactile responsiveness in the most posterior segments, followed by general paralysis and death during larval or pupal development. Adults homozygous for a temperature-sensitive allele also exhibit a loss in mobility and sensory responses. The data indicate that kinesin function is essential and suggest that kinesin has an important role in the neuromuscular system, perhaps as a motor for axonal transport. The possibility of more general cellular functions remains open, but observation of embryogenesis and morphogenesis in khc mutants suggests that mitosis and the cell cycle can proceed in spite of impaired kinesin function. Immunolocalization suggests that kinesin may have some general cellular functions but that it is not a major component of mitotic spindles.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(91)90264-y

Cites

41 of 41 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Genetic variations of Drosophila melanogaster.
Lindsley, D. L., & Grell, E. H. (1968) · Biodiversity Heritage Library (Smithsonian Institution) · doi:10.5281/zenodo.10755360 · Cited by 2,623
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility
VALE, R., REESE, T., & SHEETZ, M. (1985) · Cell · doi:10.1016/s0092-8674(85)80099-4 · Cited by 1,993
Transposition of Cloned P Elements into Drosophila Germ Line Chromosomes
Spradling, A. C., & Rubin, G. M. (1982) · Science · doi:10.1126/science.6289435 · Cited by 1,563
A stable genomic source of P element transposase in Drosophila melanogaster.
Robertson, H. M., Preston, C. R., Phillis, R. W., Johnson-Schlitz, D. M., Benz, W. K., & Engels, W. R. (1988) · Genetics · doi:10.1093/genetics/118.3.461 · Cited by 1,333
Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis
Foe, V. E., & Alberts, B. (1983) · Journal of Cell Science · doi:10.1242/jcs.61.1.31 · Cited by 1,056
Properties of the larval neuromuscular junction in Drosophila melanogaster.
Jan, L. Y., & Jan, Y. N. (1976) · The Journal of Physiology · doi:10.1113/jphysiol.1976.sp011592 · Cited by 557
KAR3, a kinesin-related gene required for yeast nuclear fusion
Meluh, P. (1990) · Cell · doi:10.1016/0092-8674(90)90351-e · Cited by 503
Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration
Hirokawa, N., Pfister, K. K., Yorifuji, H., Wagner, M. C., Brady, S. T., & Bloom, G. S. (1989) · Cell · doi:10.1016/0092-8674(89)90691-0 · Cited by 477
Vectors for P-Mediated Transformation in Drosophila
Pirrotta, V. (1988) · Elsevier eBooks · doi:10.1016/b978-0-409-90042-2.50028-3 · Cited by 402
Mutation of a gene that encodes a kinesin-like protein blocks nuclear division in A. nidulans
Enos, A. P., & Morris, N. R. (1990) · Cell · doi:10.1016/0092-8674(90)90350-n · Cited by 401

Show all 41 references

Research works printed but not linked: 1

Lindsley, 1985, The genome of Drosophila melanogaster. Part 1, Dros. Inf. Serv., 62

Sorted by citations

Items 101–200 of 201

Systematic Identification of Genes that Regulate Neuronal Wiring in the Drosophila Visual System
Berger, J., Senti, K.-A., Senti, G., Newsome, T. P., Åsling, B., Dickson, B. J., & Suzuki, T. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000085 · Cited by 55
Purification and Characterization of Native Conventional Kinesin, HSET, and CENP-E from Mitotic HeLa Cells
DeLuca, J. G., Newton, C. N., Himes, R. H., Jordan, M. A., & Wilson, L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102801200 · Cited by 55
KLP38B: A Mitotic Kinesin-related Protein That Binds PP1
Alphey, L., Parker, L., Hawcroft, G., Guo, Y., Kaiser, K., & Morgan, G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.395 · Cited by 52
Mitochondrial Transport Dynamics in Axons and Dendrites
Zinsmaier, K. E., Babić, M., & Russo, G. J. (2009) · Results and problems in cell differentiation · doi:10.1007/400_2009_20 · Cited by 52
The Microtubule Regulatory Protein Stathmin Is Required to Maintain the Integrity of Axonal Microtubules in Drosophila
Duncan, J. E., Lytle, N. K., Zuniga, A., & Goldstein, L. S. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068324 · Cited by 52
Mutation of a gene for a Drosophila kinesin-like protein, Klp38B, leads to failure of cytokinesis
Ohkura, H., Tőrők, T., Tick, G., Hoheisel, J. D., Kiss, I., & Glover, D. M. (1997) · Journal of Cell Science · doi:10.1242/jcs.110.8.945 · Cited by 51
Reconstitution of Membrane Transport Powered by a Novel Dimeric Kinesin Motor of the Unc104/Kif1a Family Purified from Dictyostelium
Pollock, N., de Hostos, E. L., Turck, C. W., & Vale, R. D. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.3.493 · Cited by 50
Kinesin Heavy Chain Function in Drosophila Glial Cells Controls Neuronal Activity
Schmidt, I., Thomas, S., Kain, P., Risse, B., Naffin, E., & Klämbt, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0349-12.2012 · Cited by 49
Two kinesins drive anterograde neuropeptide transport
Lim, A. P. C., Rechtsteiner, A., & Saxton, W. M. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-12-0820 · Cited by 49
Dynein-Dependent Transport ofnanosRNA inDrosophilaSensory Neurons Requires Rumpelstiltskin and the Germ Plasm Organizer Oskar
Xu, X., Brechbiel, J. L., & Gavis, E. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5864-12.2013 · Cited by 44
The small G protein Arl8 contributes to lysosomal function and long-range axonal transport in Drosophila
Rosa-Ferreira, C., Sweeney, S. T., & Munro, S. (2018) · Biology Open · doi:10.1242/bio.035964 · Cited by 44
cato Encodes a Basic Helix-Loop-Helix Transcription Factor Implicated in the Correct Differentiation of Drosophila Sense Organs
Goulding, S., White, N. M., & Jarman, A. P. (2000) · Developmental Biology · doi:10.1006/dbio.2000.9677 · Cited by 44
Microtubule motors: many new models off the assembly line
Vale, R. D. (1992) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(92)90440-k · Cited by 44
Universal and Unique Features of Kinesin Motors: Insights from a Comparison of Fungal and Animal Conventional Kinesins
Kirchner, J., Woehlke, G., & Schliwa, M. (1999) · Biological Chemistry · doi:10.1515/bc.1999.113 · Cited by 43
Towards an understanding of kinesin-1 dependent transport pathways through the study of protein-protein interactions
Gindhart, J. G. (2006) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/ell002 · Cited by 42
Chromosome motion in mitosis
Gorbsky, G. J. (1992) · BioEssays · doi:10.1002/bies.950140202 · Cited by 42
Mutational Analysis of Motor Proteins
Sweeney, H. L., & Holzbaur, E. L. F. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.003535 · Cited by 40
Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males.
Moore, D., Miyazaki, W. Y., Tomkiel, J. E., & Orr‐Weaver, T. L. (1994) · Genetics · doi:10.1093/genetics/136.3.953 · Cited by 41
Second-Site Noncomplementation Identifies Genomic Regions Required for Drosophila Nonmuscle Myosin Function During Morphogenesis
Halsell, S. R., & Kiehart, D. P. (1998) · Genetics · doi:10.1093/genetics/148.4.1845 · Cited by 39
Axonal accumulation of synaptic markers in APP transgenic Drosophila depends on the NPTY motif and is paralleled by defects in synaptic plasticity
Rusu, P. M., Jansen, A., Soba, P., Kirsch, J., Loewer, A., Merdes, G., Kuan, Y., Jung, A. G., Beyreuther, K. T., Kjærulff, O., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05341.x · Cited by 40
Molecular and functional characteristics of MAP-2a: Ability of MAP-2a versus MAP-2b to induce stable microtubules in COS cells
Kalcheva, N., Rockwood, J. M., Kress, Y., Steiner, A. M., & Shafit‐Zagardo, B. (1998) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1998)40:3 · Cited by 35
Tau isoform‐specific modulation of kinesin‐driven microtubule gliding rates and trajectories as determined with tau‐stabilized microtubules
Peck, A. J., Sargin, M. E., LaPointe, N. E., Rose, K. H., Manjunath, B. S., Feinstein, S. C., & Wilson, L. (2010) · Cytoskeleton · doi:10.1002/cm.20494 · Cited by 34
Mitosis: Spindle assembly and chromosome motion
Wadsworth, P. (1993) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(05)80017-1 · Cited by 34
Genetic Interactions Between the RhoA and Stubble-stubbloid Loci Suggest a Role for a Type II Transmembrane Serine Protease in Intracellular Signaling During Drosophila Imaginal Disc Morphogenesis
Bayer, C. A., Halsell, S. R., Fristrom, J. W., Kiehart, D. P., & von Kalm, L. (2003) · Genetics · doi:10.1093/genetics/165.3.1417 · Cited by 33
The Non-amyloidal Component Region of α-Synuclein Is Important for α-Synuclein Transport Within Axons
Anderson, E. N., Hirpa, D., Zheng, K. H., Banerjee, R., & Gunawardena, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00540 · Cited by 32
Chapter 4 From Clone to Mutant Gene
Hamilton, B. A., & Zinn, K. (1994) · Methods in cell biology · doi:10.1016/s0091-679x(08)60907-3 · Cited by 29
Kinesin-1 tail autoregulation and microtubule-binding regions function in saltatory transport but not ooplasmic streaming
Moua, P., Fullerton, D., Serbus, L. R., Warrior, R., & Saxton, W. M. (2011) · Development · doi:10.1242/dev.048645 · Cited by 26
Abl Tyrosine Kinase and Its Substrate Ena/VASP Have Functional Interactions with Kinesin-1
Martin, M., Ahern-Djamali, S. M., Hoffmann, F. M., & Saxton, W. M. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-02-0116 · Cited by 24
Intact Lysosome Transport and Phagosome Function Despite Kinectin Deficiency
Plitz, T., & Pfeffer, K. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.6044-6055.2001 · Cited by 25
Heterotrimeric kinesin‐2, together with kinesin‐1, steers vesicular acetylcholinesterase movements toward the synapse
Kulkarni, A., Khan, Y., & Ray, K. (2016) · The FASEB Journal · doi:10.1096/fj.201600759rrr · Cited by 23
Mitotic spindle pole separation
Saunders, W. S. (1993) · Trends in Cell Biology · doi:10.1016/0962-8924(93)90032-v · Cited by 23
Clonal Tests of Conventional Kinesin Function during Cell Proliferation and Differentiation
Brendza, R. P., Sheehan, K. B., Turner, F. R., & Saxton, W. M. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.4.1329 · Cited by 23
Motors for fast axonal transport
Schroer, T. A. (1992) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(92)90028-j · Cited by 23
Mitosis in Neurons: Roughex and APC/C Maintain Cell Cycle Exit to Prevent Cytokinetic and Axonal Defects in Drosophila Photoreceptor Neurons
Ruggiero, R. P., Kale, A., Thomas, B. J., & Baker, N. E. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003049 · Cited by 22
A Kinesin Mutation That Uncouples Motor Domains and Desensitizes the γ-Phosphate Sensor*
Brendza, K., Sontag, C., Saxton, W., & Gilbert, S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001124200 · Cited by 14
A Novel Calcium/Calmodulin-Regulated Kinesin-Like Protein is Highly Conserved between Monocots and Dicots
Abdel‐Ghany, S. E., & Reddy, A. S. N. (2000) · DNA and Cell Biology · doi:10.1089/104454900439791 · Cited by 21
Comparison of the intracellular distribution of cytoplasmic dynein and kinesin in cultured cells: Motor protein location does not reliably predict function
Lin, S. X. H., Pfister, K. K., & Collins, C. A. (1996) · Cell Motility and the Cytoskeleton · doi:10.1002/(sici)1097-0169(1996)34:4 · Cited by 22
Three Routes to Suppression of the Neurodegenerative Phenotypes Caused by Kinesin Heavy Chain Mutations
Djagaeva, I., Rose, D. J., Lim, A. P. C., Venter, C. E., Brendza, K. M., Moua, P., & Saxton, W. M. (2012) · Genetics · doi:10.1534/genetics.112.140798 · Cited by 19
Molecular pathogenesis of peripheral neuropathies: insights from Drosophila models
Bussmann, J., & Storkebaum, E. (2017) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2017.01.011 · Cited by 20
The Actin-Binding Protein Capulet Genetically Interacts with the Microtubule Motor Kinesin to Maintain Neuronal Dendrite Homeostasis
Medina, P. M. B., Worthen, R. J., Forsberg, L. J., & Brenman, J. E. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003054 · Cited by 20
Hypoxia-induced mitochondrial and nuclear DNA damage in the rat brain
Englander, E. W., Greeley, G. H., Wang, G., Perez-Polo, J. R., & Lee, H.-M. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991015)58:2 · Cited by 51
Kinesins in the nervous system
Martin, M., Hurd, D. D., & Saxton, W. M. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050422 · Cited by 20
Genetic analysis of neurotransmitter release at the synapse
Schwarz, T. L. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90003-5 · Cited by 20
HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury
Krzystek, T. J., White, J. A., Rathnayake, R., Thurston, L., Hoffmar-Glennon, H., Li, Y., & Gunawardena, S. (2022) · Autophagy · doi:10.1080/15548627.2022.2119351 · Cited by 19
Temperature-sensitive paralytic mutants: insights into the synaptic vesicle cycle
Vijayakrishnan, N., & Broadie, K. S. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340081 · Cited by 18
Chapter 16 Isolation and Analysis of Microtubule Motor Proteins
Saxton, W. M. (1994) · Methods in cell biology · doi:10.1016/s0091-679x(08)60919-x · Cited by 17
Presynaptic Precursor Vesicles—Cargo, Biogenesis, and Kinesin-Based Transport across Species
Petzoldt, A. G. (2023) · Cells · doi:10.3390/cells12182248 · Cited by 18
Axonal transport and neurodegenerative disease: vesicle-motor complex formation and their regulation
Gunawardena, S., Anderson, E. N., & White, J. (2014) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s57502 · Cited by 16
Kinesin Light Chain 1 Suppression Impairs Human Embryonic Stem Cell Neural Differentiation and Amyloid Precursor Protein Metabolism
Killian, R. L., Flippin, J. D., Herrera, C. M., Almenar‐Queralt, A., & Goldstein, L. S. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029755 · Cited by 14
A role for kinesin heavy chain in controlling vesicle transport into dendrites inDrosophila
Schimmelpfeng, K., Roux, M. S., Herrera, C. M., & Goldstein, L. S. B. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-07-0572 · Cited by 13
Role of Kinesin Heavy Chain in Crumbs Localization along the Rhabdomere Elongation in Drosophila Photoreceptor
League, G. P., & Nam, S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021218 · Cited by 13
Dynein catch bond as a mediator of codependent bidirectional cellular transport
Puri, P., Gupta, N., Chandel, S., Naskar, S., Nair, A., Chaudhuri, A., Mitra, M. K., & Muhuri, S. (2019) · Physical Review Research · doi:10.1103/physrevresearch.1.023019 · Cited by 14
Molecular Motors and Cell Motility in the Brain
Mercer, J. A., Albanesi, J. P., & Brady, S. T. (1994) · Brain Pathology · doi:10.1111/j.1750-3639.1994.tb00827.x · Cited by 13
The Drosophila kinesin‐I associated protein YETI binds both kinesin subunits
Wisniewski, T., Tanzi, C. L., & Gindhart, J. G. (2003) · Biology of the Cell · doi:10.1016/j.biolcel.2003.10.004 · Cited by 12
Mechanical and functional properties of epothilone‐stabilized microtubules
Yu, D., Pessino, V., Kuei, S., & Valentine, M. T. (2012) · Cytoskeleton · doi:10.1002/cm.21091 · Cited by 12
Small Molecule Suppressors of Drosophila Kinesin Deficiency Rescue Motor Axon Development in a Zebrafish Model of Spinal Muscular Atrophy
Gassman, A., Hao, L. T., Bhoite, L. T., Bradford, C. L., Chien, C.-B., Beattie, C. E., & Manfredi, J. P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074325 · Cited by 11
Techniques to Dissect Cellular and Subcellular Function in the Drosophila Nervous System
Matthies, H. J. G., & Broadie, K. S. (2003) · Methods in cell biology · doi:10.1016/s0091-679x(03)01011-2 · Cited by 11
Dynamic microtubule organization and mitochondrial transport are regulated by distinct Kinesin-1 pathways
Melkov, A., Simchoni, Y., Alcalay, Y., & Abdu, U. (2015) · Biology Open · doi:10.1242/bio.015206 · Cited by 11
Kinesin-like molecules involved in spindle formation
Rodionov, V., Gelfand, V. I., & Borisy, G. G. (1993) · Journal of Cell Science · doi:10.1242/jcs.106.4.1179 · Cited by 11
The Drosophila NMJ: a genetic model system for synapse formation and function
Broadie, K. S., & Bate, M. (1995) · Seminars in Developmental Biology · doi:10.1016/s1044-5781(06)80031-9 · Cited by 10
The FHA domain is essential for autoinhibition of KIF1A/UNC-104 proteins
Niwa, S., Watanabe, T., & Chiba, K. (2024) · Journal of Cell Science · doi:10.1242/jcs.262017 · Cited by 9
Kinesin‐1 inhibits the aggregation of amyloid‐β peptide as detected by fluorescence cross‐correlation spectroscopy
Zheng, Y.-P., Tian, S., Peng, X.-L., Yang, J., Fu, Y.-H., Jiao, Y.-Y., Zhao, J., He, J., & Hong, T. (2016) · FEBS Letters · doi:10.1002/1873-3468.12137 · Cited by 9
One gene, many phenotypes: the role of KIF5A in neurodegenerative and neurodevelopmental diseases
Cozzi, M., Tedesco, B., Ferrari, V., Chierichetti, M., Pramaggiore, P., Cornaggia, L., Magdalena, R., Brodňanová, M., Mohamed, A. A., Milioto, C., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02277-x · Cited by 10
Spatial and Temporal Characteristics of Normal and Perturbed Vesicle Transport
Iacobucci, G. J., Rahman, N. A., Valtueña, A. A., Nayak, T. K., & Gunawardena, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097237 · Cited by 8
Radiation Hybrids: A valuable Tool for Genetic, Genomic and Functional Analysis of Plant Genomes
Kumar, A., Bassi, F. M., de Jimenez, M. K. M., Ghavami, F., Mazaheri, M., Simons, K. J., Iqbal, M. J., Mergoum, M., Kianian, S. F., & Kianian, P. M. A. (2013) · Springer eBooks · doi:10.1007/978-94-007-7572-5_12 · Cited by 8
Timing of mitotic chromosome loss caused by the ncd mutation of Drosophila melanogaster
Nelson, C. R., & Szauter, P. (1992) · Cell Motility and the Cytoskeleton · doi:10.1002/cm.970230105 · Cited by 8
Cell Cycle Genes of Drosophila
González, C., Alphey, L., & Glover, D. M. (1994) · Advances in genetics · doi:10.1016/s0065-2660(08)60396-x · Cited by 8
4.17 Kinesin Structure and Biochemistry
Gilbert, S. P., & Sardar, H. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374920-8.00421-5 · Cited by 6
Glu415 in the α-tubulins plays a key role in stabilizing the microtubule–ADP-kinesin complexes
Gáspár, I., & Szabad, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.050252 · Cited by 6
Localization of the human kinesin-related gene to band 10q24 by fluorescence in situ hybridization
Tihy, F., Kress, M., Harper, M., Dutrillaux, B., & Lemieux, N. (1992) · Genomics · doi:10.1016/0888-7543(92)90075-4 · Cited by 6
5 Microtubule Motors in the Early Sea Urchin Embryo
Wright, B. D., & Scholey, J. M. (1992) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(08)60441-x · Cited by 6
CK2α regulates the transcription of BRP in Drosophila
Wairkar, Y. P., Trivedi, D., Natarajan, R., Barnes, K., Dolores, L. K., & Cho, P. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.09.025 · Cited by 5
Drosophila Models of Hereditary Spastic Paraplegia
Ozdowski, E. F., Baxter, S. L., & Sherwood, N. T. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405195-9.00073-1 · Cited by 5
Molecular motors − a paradigm for mutant analysis
Endow, S. A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.8.1311 · Cited by 5
Cilia and Related Microtubular Arrays in the Eukaryotic Cell
Satir, P. (1997) · Comprehensive physiology · doi:10.1002/cphy.cp140120 · Cited by 5
Walking motion of an overdamped active particle in a ratchet potential
Lee, K.-J.-B., Kim, C. K., & Chung, M.-H. (2011) · Journal of Biological Physics · doi:10.1007/s10867-011-9249-1 · Cited by 4
Kinesins in the spindle: an update
Epstein, H., & Scholey, J. M. (1992) · Trends in Cell Biology · doi:10.1016/0962-8924(92)90171-i · Cited by 4
Different Mechanisms Link Gain and Loss of Kinesin Functions to Axonal DegenerationPreprint
Liew, Y.-T., Bailey, D. M., Cairns, W., Day, M., Dajas‐Bailador, F., Jones, E., McCann, S., Landgraf, M., Lorenzo-Cisneros, L., Murphy, T., et al. (2025) · SSRN Electronic Journal · doi:10.1101/2024.12.31.630930 · Cited by 4
The Kinesin Superfamily
Wordeman, L. G. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-788-0_3 · Cited by 3
Fast Axonal Transport: a Site of Acrylamide Neurotoxicity: a Rebuttal
Sickles, D. W., Stone, D., & Friedman, M. A. (2002) · NeuroToxicology · doi:10.1016/s0161-813x(02)00026-8 · Cited by 3
Motor vesicles
Hedgecock, E. M., & Hall, D. H. (1991) · Current Biology · doi:10.1016/0960-9822(91)90282-2 · Cited by 3
Kinesin Superfamily Proteins
Hirokawa, N., & Takemura, R. (2008) · Wiley eBooks · doi:10.1002/9783527610754.mp01 · Cited by 3
New cell biological explanations for kinesin-linked axon degenerationPreprint
Liew, Y.-T., Voelzmann, A., Pinho-Correia, L. M., Murphy, T., Tortoishell, H., Parkin, J., Bailey, D. M., Landgraf, M., & Prokop, A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.23.473961 · Cited by 3
Dynein Heavy Chain 64C Differentially Regulates Cell Survival and Proliferation of Wingless-Producing Cells in Drosophila melanogaster
Kim, J.-Y., Tsogtbaatar, O., & Cho, K.-O. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9040043 · Cited by 2
Dissection and Direct Imaging of Axonal Transport in Drosophila Segmental Nerves
Saxton, W. M., Lim, A. P. C., & Djagaeva, I. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1990-2_19 · Cited by 2
Molecular Motors: Subdomain Dynamics and Mechanochemistry
Singh, M., & Singh, S. K. (2020) · Springer eBooks · doi:10.1007/978-981-15-5530-5_15 · Cited by 1
Engineering a Molecular Railroad
Stewart, R. J., & Limberis, L. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-218-2_18 · Cited by 1
Motor proteins in mitosis and meiosis
Yen, T. J. (1995) · The Cytoskeleton · doi:10.1016/s1874-6020(06)80006-6 · Cited by 1
Genetic Dissection of Drosophila Cytoskeletal Functions
Fyrberg, E. A. (1995) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60264-7 · Cited by 1
Crosslinking studies on the conventional kinesin of Neurospora crassa
Hahlen, K. (2004) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2619
Creation of a heat-inducibleDrosophila RhoA+transgene and chromosomal mapping of the genomic insertions of the transgene
Filak, M., Johnson, R., Campo, J. J., & Halsell, S. R. (2014) · BIOS · doi:10.1893/0005-3155-85.1.18
Overexpression of APPL, a Drosophila APP Homologue, Compromises Microtubule Associated Axonal Transport and Promotes Synapse Formation
Torroja, L., Packard, M. C., Budnik, V., & White, K. (2001) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-662-04399-8_12
Störungen des axonalen Transports bei der hereditären spastischen Spinalparalyse im Drosophila -Modell
Direktor, Ä., & Gasser, T. (2011)
Dynein catch bond as a mediator of codependent bidirectional cellular transportPreprint
Puri, P., Gupta, N., Chandel, S., Naskar, S., Nair, A., Chaudhuri, A., Mitra, M. K., & Muhuri, S. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/250175
Modeling Hereditary Spastic Paraplegias in Fruit Flies: Potential of Its Genetic Paraphernalia
Bhat, S. A., & Kumar, V. (2019) · Springer eBooks · doi:10.1007/978-981-13-2218-1_14
Faculty Opinions recommendation of Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons.
Akhmanova, A. S. (2006) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1031329.368707
Motor protein disruption critically alters organelle trafficking, NMJ formation, and excitation contraction couplingPreprint
Bansal, H., Hana, T. A., Michael, A. H., Kamaridinova, S. U., Bransford, J., & Ormerod, K. G. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.10.658915
Microtubule curling as an efficient readout to uncover fundamental concepts of axonal cell biology and neurodegenerationPreprint
Voelzmann, A., Owens, M., Beaven, R., Cairns, W., Elliot, A., Feng, S.-H., Fülle, J. B., Gonçalves‐Pimentel, C., Hahn, I., Jones, E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.27.662005
Cilia and Related Microtubular Arrays in the Eukaryotic Cell
Satir, P. (1996) · Comprehensive physiology · doi:10.1002/j.2040-4603.1996.tb01770.x
L'alpha-tubuline B et ses régulateurs chez le champignon Botrytis cinerea : régulation, rôles et interactants
Talmey, Y. F. (2014) · theses.fr (ABES) · doi:10.70675/19614ee5zadd0z4838z930cz4ac6a7f7afc4

Authors: Saxton, W. M., Hicks, J., Goldstein, L. S. B., & Raff, E. C.
Affiliations: Indiana University Bloomington (US)
Harvard University (US)
ORCID: Goldstein, Lawrence S.B.
Venue: Cell
Publisher: Elsevier BV
Published: 1991-03
Volume: 64
Issue: 6
Pages: 1093-1102
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90264-y
OpenAlex: W1996061686
Cited by: 201
References: 41
Citations by year: 2025: 4 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 5 · 2012: 10
FWCI: 7.67
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd016739-13)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 16739)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: kinesin heavy chain, microtubule motor proteins, Drosophila, lethality, neuromuscular function, axonal transport, mitosis, mitotic spindle, embryonic development, morphogenesis, temperature-sensitive mutants, larval locomotion, sensory responses
MeSH terms: Adenosine Triphosphatases, Alleles, Animals, Drosophila, Immunohistochemistry, Larva, Microtubule Proteins, Mitosis, Motor Activity, Mutation, Kinesins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defects in mitosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks