Cited by 558Genomics and Chromatin DynamicsCancer-related Molecular PathwaysEpigenetics and DNA Methylation

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Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

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Prendergast, George C., Lawe, Deirdre, Ziff, Edward B.·1991·Cell

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Abstract

Myn, a novel murine approximately 18 kd basic/helix-loop-helix/"leucine zipper" (B/HLH/LZ) protein, forms a specific DNA-binding complex with the c-Myc oncoprotein through the HLH/LZ motif in both proteins. c-Myc/Myn recognizes a c-Myc-binding site (GACCACGTGGTC) with higher affinity than either protein by itself. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the c-Myc/Myn complex in vivo. In 3T3 fibroblasts, Myn mRNA levels are induced several-fold by serum with delayed early kinetics, suggesting regulation by immediate-early gene products. Coexpression of Myn in a myc/ras rat embryo fibroblast focus formation assay specifically augmented c-myc transforming activity. We suggest that interaction of Myn with c-Myc stabilizes sequence-specific DNA binding in vivo.

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Authors: Prendergast, G. C., Lawe, D., & Ziff, E. B.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Prendergast, George C.
Ziff, Edward B.
Venue: Cell
Publisher: Elsevier BV
Published: 1991-05
Volume: 65
Issue: 3
Pages: 395-407
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(91)90457-a
OpenAlex: W2049114614
Cited by: 558
References: 71
Citations by year: 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 14
FWCI: 27.23
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 5208 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Science Foundation
Howard Hughes Medical Institute
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Keywords: c-Myc, protein-protein interaction, DNA binding, CpG methylation, serum induction, immediate early genes, 3T3 fibroblasts, focus formation
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Blood, Cell Transformation, Neoplastic, Cells, Cultured, DNA, DNA-Binding Proteins, Gene Expression Regulation, Methylation, Molecular Sequence Data, Genes, ras, Transfection, Polymerase Chain Reaction, Genes, myc, Proto-Oncogene Proteins c-myc, Leucine Zippers, Mice, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

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Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation

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