The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
Open accessAbstract
Myn, a novel murine approximately 18 kd basic/helix-loop-helix/"leucine zipper" (B/HLH/LZ) protein, forms a specific DNA-binding complex with the c-Myc oncoprotein through the HLH/LZ motif in both proteins. c-Myc/Myn recognizes a c-Myc-binding site (GACCACGTGGTC) with higher affinity than either protein by itself. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the c-Myc/Myn complex in vivo. In 3T3 fibroblasts, Myn mRNA levels are induced several-fold by serum with delayed early kinetics, suggesting regulation by immediate-early gene products. Coexpression of Myn in a myc/ras rat embryo fibroblast focus formation assay specifically augmented c-myc transforming activity. We suggest that interaction of Myn with c-Myc stabilizes sequence-specific DNA binding in vivo.
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“The manipulation of the methylation status of DNA sequences has been shown (mostly in in vitro studies) to result in the differential binding of TFs, including E2F, AP2α, MYC and MYN88–95.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [95]
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Frommer, M., McDonald, L. E., Millar, D. S., Collis, C. M., Watt, F., Grigg, G. W., Molloy, P. L., & Paul, C. L. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1827 · Cited by 3,238
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Metadata
- Authors
- Prendergast, G. C., Lawe, D., & Ziff, E. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 65
- Issue
- 3
- Pages
- 395-407
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2049114614
- Cited by
- 558
- References
- 71
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 14
- FWCI
- 27.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- c-Myc, protein-protein interaction, DNA binding, CpG methylation, serum induction, immediate early genes, 3T3 fibroblasts, focus formation
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Blood, Cell Transformation, Neoplastic, Cells, Cultured, DNA, DNA-Binding Proteins, Gene Expression Regulation, Methylation, Molecular Sequence Data, Genes, ras, Transfection, Polymerase Chain Reaction, Genes, myc, Proto-Oncogene Proteins c-myc, Leucine Zippers, Mice, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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