The DOI matches its Crossref record; 70 of the 71 references it cites were found in a registry or an index.
Association of Myn, the murine homolog of Max, with c-Myc stimulates methylation-sensitive DNA binding and ras cotransformation
Open accessAbstract
Myn, a novel murine approximately 18 kd basic/helix-loop-helix/"leucine zipper" (B/HLH/LZ) protein, forms a specific DNA-binding complex with the c-Myc oncoprotein through the HLH/LZ motif in both proteins. c-Myc/Myn recognizes a c-Myc-binding site (GACCACGTGGTC) with higher affinity than either protein by itself. CpG methylation of the recognition site greatly inhibits DNA binding, suggesting that DNA methylation may regulate the c-Myc/Myn complex in vivo. In 3T3 fibroblasts, Myn mRNA levels are induced several-fold by serum with delayed early kinetics, suggesting regulation by immediate-early gene products. Coexpression of Myn in a myc/ras rat embryo fibroblast focus formation assay specifically augmented c-myc transforming activity. We suggest that interaction of Myn with c-Myc stabilizes sequence-specific DNA binding in vivo.
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“The manipulation of the methylation status of DNA sequences has been shown (mostly in in vitro studies) to result in the differential binding of TFs, including E2F, AP2α, MYC and MYN88–95.”
From Transcription factors as readers and effectors of DNA methylation (2016) · cites this paper as [95]
Citations
Cites
A comprehensive set of sequence analysis programs for the VAX
Devereux, J., Haeberli, P. E., & Smithies, O. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.1part1.387 · Cited by 14,222
A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,327
The Leucine Zipper: A Hypothetical Structure Common to a New Class of DNA Binding Proteins
Landschulz, W. H., Johnson, P. F., & McKnight, S. L. (1988) · Science · doi:10.1126/science.3289117 · Cited by 3,443
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713
The protein Id: A negative regulator of helix-loop-helix DNA binding proteins
Benezra, R., Davis, R. L., Lockshon, D., Turner, D. L., & Weintraub, H. M. (1990) · Cell · doi:10.1016/0092-8674(90)90214-y · Cited by 2,202
How eukaryotic transcriptional activators work
Ptashne, M. (1988) · Nature · doi:10.1038/335683a0 · Cited by 1,828
Amino Acid Preferences for Specific Locations at the Ends of α Helices
Richardson, J. S., & Richardson, D. C. (1988) · Science · doi:10.1126/science.3381086 · Cited by 1,364
Ruley, H. E. (1983) · Nature · doi:10.1038/304602a0 · Cited by 1,248
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Yow, C. X., Yeoh, S., Leen, E. N., & Bayliss, R. W. (2026) · Bioscience Reports · doi:10.1042/bsr20250104 · Cited by 1
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Zhang, S. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/dbjc-1074 · Cited by 1
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Pappa, V. I., & Young, B. D. (2006) · Elsevier eBooks · doi:10.1016/b978-0-7216-0081-9.50007-8 · Cited by 1
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Cechova, K., Gu, W., Ye, B. H., Lo‐Coco, F., Chang, C., Zhang, J., Migliazza, A., Mellado, W., Niu, H., & Dalla‐Favera, R. (1995) · Springer eBooks · doi:10.1007/978-1-4615-1927-0_12 · Cited by 1
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Veronese, M. L., Bullrich, F., & Croce, C. M. (1999) · Humana Press eBooks · doi:10.1007/978-1-59259-699-7_7 · Cited by 1
Amendola, R. (1994) · DNA and Cell Biology · doi:10.1089/dna.1994.13.1099 · Cited by 1
Genetic factors in lung disease Part II: Lung cancer and angiotensin converting enzyme gene
Kawakami, Y., Yamaguchi, E., Munakata, M., Dosaka‐Akita, H., & FURUYA, K. (1997) · Respirology · doi:10.1111/j.1440-1843.1997.tb00059.x · Cited by 1
Shi, C., Wang, P., Hu, Y., & Xu, L. (1995) · Cell Research · doi:10.1038/cr.1995.3 · Cited by 1
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Zervos, A. S., & Brent, R. (1993) · Cited by 1
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Shimono, A., Kitamua, A., Hanaoka, K., & Kondoh, H. (1996) · Development Growth & Differentiation · doi:10.1046/j.1440-169x.1996.t01-1-00014.x · Cited by 1
Targeted MYCN suppression and its effect on miRNA in neuroblastoma
Henriksen, J. R. (2010) · NORA - Norwegian Open Research Archives · Cited by 1
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Trump, B. F. (1991) · Toxicologic Pathology · doi:10.1177/019262339101900409 · Cited by 1
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Melkoumian, Z. (2001) · doi:10.33915/etd.1440 · Cited by 1
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Ohn, J., Ames, J. B., Owning, R. D., & Rist, W. (1996) · Cited by 1
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Scott, B., & Lo, D. D. (1994) · Elsevier eBooks · doi:10.1016/b978-0-12-105760-2.50013-3
Dang, C. V., & Lee, L. A. (1995) · Medical intelligence unit · doi:10.1007/978-3-662-22681-0_8
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Mo, H. (2006) · Figshare
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Bashtrykov, P. (2014) · OPUS Publication Server of the University of Stuttgart (University of Stuttgart) · doi:10.18419/opus-1407
Kanduri, M. (2004) · KTH Publication Database DiVA (KTH Royal Institute of Technology)
On the correlation of CTCF binding and c-myc amplification in human prostate cancer cell linesPreprint
Fleischmann, T. T., & Assum, G. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/009761
Analyse der Expression von Mutanten p53 in normalen und Tumorzellen
Deppert, W. (2000)
Ershler, W. B., Dunn, B. K., & Longo, D. L. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3764-2_49
Identifying FoxA1 interacting partners : insight into androgen regulated prostatic genes.
Sun, Q. (2010) · Europe PMC (PubMed Central)
Yu, M., & Lüscher, B. (2005) · RWTH Publications (RWTH Aachen)
Study of protein-protein interactions in molecular epigenetics
Dhayalan, A. (2009)
Aberrant DNA Methylation Patterns in Gynecologic Cancers
Beetch, M., Bai, Y., Lubecka, K., Stefañska, B., & Lelièvre, S. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812215-0.00024-8
The Role of the Transactivation Domain in c-Myc Mediated Cell Cycle Progression and Transformation
West-Osterfield, K. (2008)
Kenney, A. M., & Rowitch, D. H. (2007) · Springer eBooks · doi:10.1007/0-387-33777-6_15
Global DNA Demethylation During Erythropoiesis: A Dissertation
Shearstone, J. R. (2011) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/hs36-k802
Neoplasias Involving Translocation of Antigen Receptor Genes
(2007) · Springer eBooks · doi:10.1007/978-0-585-31180-7_6
Alves, D. C. C., Toffoli, L. V., da Silva, W. R., Estrada, V. B., Veríssimo, L. F., Punhagui, A. P. F., Erthal, R. P., Miguel, M. V. O., Gomes, M. V., Fernandes, G. S. A., et al. (2025) · Physiology & Behavior · doi:10.1016/j.physbeh.2025.115058
Seibert, M., Kurrle, N., Kaleab, S., Wempe, F., von Metzler, I., Serve, H. L., & Schnütgen, F. (2026) · Scientific Reports · doi:10.1038/s41598-026-47974-w
BindingDB Entry 50042315: Pharmacophore identification of c-Myc inhibitor 10074-G5.
BindingDB (2013) · UC San Diego · doi:10.7270/q2wm1fpm
Ung, M. H., Lou, S., Varn, F. S., & Cheng, C. (2015) · Springer eBooks · doi:10.1007/978-3-319-15811-2_13
Metadata
- Authors
- Prendergast, G. C., Lawe, D., & Ziff, E. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1991-05
- Volume
- 65
- Issue
- 3
- Pages
- 395-407
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2049114614
- Cited by
- 558
- References
- 71
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 4 · 2014: 10 · 2013: 5 · 2012: 14
- FWCI
- 27.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Howard Hughes Medical Institute
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- c-Myc, protein-protein interaction, DNA binding, CpG methylation, serum induction, immediate early genes, 3T3 fibroblasts, focus formation
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Blood, Cell Transformation, Neoplastic, Cells, Cultured, DNA, DNA-Binding Proteins, Gene Expression Regulation, Methylation, Molecular Sequence Data, Genes, ras, Transfection, Polymerase Chain Reaction, Genes, myc, Proto-Oncogene Proteins c-myc, Leucine Zippers, Mice, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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