Cited by 3,984Epigenetics and DNA MethylationGenetic Syndromes and ImprintingAnimal Genetics and Reproduction

The DOI matches its Crossref record; 59 of the 61 references it cites were found in a registry or an index.

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Li, En, Bestor, Timothy H., Jaenisch, Rudolf·1992·Cell

Open this paper in CoChat — free account

Abstract

Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA methyltransferase gene. ES cell lines homozygous for the mutation were generated by consecutive targeting of both wild-type alleles; the mutant cells were viable and showed no obvious abnormalities with respect to growth rate or morphology, and had only trace levels of DNA methyltransferase activity. A quantitative end-labeling assay showed that the level of m5C in the DNA of homozygous mutant cells was about one-third that of wild-type cells, and Southern blot analysis after cleavage of the DNA with a methylation-sensitive restriction endonuclease revealed substantial demethylation of endogenous retroviral DNA. The mutation was introduced into the germline of mice and found to cause a recessive lethal phenotype. Homozygous embryos were stunted, delayed in development, and did not survive past mid-gestation. The DNA of homozygous embryos showed a reduction of the level of m5C similar to that of homozygous ES cells. These results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.

Integrity signals

Registry

Crossref · 10.1016/0092-8674(92)90611-f

Cites

59 of 59 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids.
Wessel, D., & Flügge, U. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90782-6 · Cited by 3,997
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: A general strategy for targeting mutations to non-selectable genes
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,519
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Self-citation
X inactivation, differentiation, and DNA methylation
Riggs, A. D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000130315 · Cited by 1,343
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development
Monk, M., Boubelı́k, M., & Lehnert, S. A. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,100
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells
Bestor, T. H., Laudano, A. P., Mattaliano, R. J., & Ingram, V. M. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913
Self-citation

Show all 61 references

Sorted by citations

Items 901–1,000 of 1,016

DNA methylation in early development
Geiman, T. M., & Muegge, K. (2009) · Molecular Reproduction and Development · doi:10.1002/mrd.21118 · Cited by 132
The Control of Natural Variation in Cytosine Methylation in Arabidopsis
Riddle, N. C., & Richards, E. J. (2002) · Genetics · doi:10.1093/genetics/162.1.355 · Cited by 132
Epigenetic reprogramming and development: a unique heterochromatin organization in the preimplantation mouse embryo
Burton, A., & Torres‐Padilla, M. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq027 · Cited by 132
Melatonin improves the fertilization capacity and developmental ability of bovine oocytes by regulating cytoplasmic maturation events
Zhao, X., Wang, N., Hao, H., Li, C., Zhao, Y., Yan, C., Wang, H., Du, W., Wang, D., Liu, Y., et al. (2017) · Journal of Pineal Research · doi:10.1111/jpi.12445 · Cited by 132
PCNA clamp facilitates action of DNA cytosine methyltransferase 1 on hemimethylated DNA
Iida, T., Suetake, I., Tajima, S., Morioka, H., Ohta, S., Obuse, C., & Tsurimoto, T. (2002) · Genes to Cells · doi:10.1046/j.1365-2443.2002.00584.x · Cited by 132
DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system
Geiman, T. M., Sankpal, U. T., Robertson, A. K., Zhao, Y., Zhao, Y., & Robertson, K. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.04.058 · Cited by 144
Cancer-Linked DNA Hypomethylation and Its Relationship to Hypermethylation
Ehrlich, M. (2006) · Springer eBooks · doi:10.1007/3-540-31181-5_12 · Cited by 131
Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids
Kishigami, S., Thuan, N. V., Hikichi, T., Ohta, H., Wakayama, S., Mizutani, E., & Wakayama, T. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.10.026 · Cited by 134
Characterization of an Arabidopsis thaliana DNA hypomethylation mutant
Kakutani, T., Jeddeloh, J. A., & Richards, E. J. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.1.130 · Cited by 139
Epigenetic Variation Illustrated by DNA Methylation Patterns of the Fragile-X Gene FMR1
Stöger, R. J., Kajimura, T., Brown, W. T., & Laird, C. D. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.11.1791 · Cited by 129
Spermatozoal nuclear determinants of reproductive outcome: implications for ART
Seli, E. U., & Sakkas, D. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi011 · Cited by 131
Methylenetetrahydrofolate reductase 677C→T polymorphism affects DNA methylation in response to controlled folate intake in young women
Shelnutt, K. P., KAUWELL, G. P. A., Gregory, J. F., Maneval, D. R., Quinlivan, E. P., Theriaque, D. W., Henderson, G. N., & Bailey, L. B. (2004) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2004.04.003 · Cited by 131
Genome-Wide Epigenetic Alterations in Cloned Bovine Fetuses1
Cezar, G. G., Bartolomei, M. S., Forsberg, E. J., First, N. L., Bishop, M. D., & Eilertsen, K. J. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.010181 · Cited by 131
MiR-205 in cancer: An angel or a devil?
Qin, A.-Y., Zhang, X., Liu, L., Yu, J.-P., Li, H., Wang, S.-Z. E., Ren, X.-B., & Cao, S. (2012) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2012.11.002 · Cited by 130
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier
Watanabe, A., Yamada, Y., & Yamanaka, S. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0292 · Cited by 133
The chemistries and consequences of DNA and RNA methylation and demethylation
Traube, F. R., & Carell, T. (2017) · RNA Biology · doi:10.1080/15476286.2017.1318241 · Cited by 131
Promoter hypomethylation of a novel cancer/testis antigen gene CAGE is correlated with its aberrant expression and is seen in premalignant stage of gastric carcinoma
Cho, B., Lee, H., Jeong, S., Bang, Y., Lee, H. J., Hwang, K. S., Kim, H., Lee, Y., Kang, G. H., & Jeoung, D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01121-5 · Cited by 130
Mechanisms of DNA Demethylation in Chicken Embryos
Jost, J., Siegmann, M., Sun, L., & Leung, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.17.9734 · Cited by 130
Recombinant Human DNA (Cytosine-5) Methyltransferase
Bacolla, A., Pradhan, S., Roberts, R. J., & Wells, R. D. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33011 · Cited by 131
DNA modification by methyltransferases
Cheng, X. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80003-j · Cited by 129
Multistep carcinogenesis of the colon in ApcMin/+ mouse
Yamada, Y., & Mori, H. (2006) · Cancer Science · doi:10.1111/j.1349-7006.2006.00348.x · Cited by 129
Induction of oocyte-like cells from mouse embryonic stem cells by co-culture with ovarian granulosa cells
Qing, T., Shi, Y., Qin, H., Ye, X., Wei, W., Liu, H., Ding, M., & Deng, H. (2007) · Differentiation · doi:10.1111/j.1432-0436.2007.00181.x · Cited by 129
LSH and G9a/GLP complex are required for developmentally programmed DNA methylationPreprint
Myant, K., Termanis, A., Sundaram, A. Y. M., Boe, T., Li, C., Merusi, C., Burrage, J., Heras, J. I. D. L., & Stancheva, I. (2010) · Genome Research · doi:10.1101/gr.108498.110 · Cited by 135
DNA methylation: a promising landscape for immune system-related diseases
Suárez-Álvarez, B., Rodríguez, R. M. A., Fraga, M. F., & López‐Larrea, C. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.06.005 · Cited by 133
Epigenetic Regulation of Mesenchymal Stem Cells: A Focus on Osteogenic and Adipogenic Differentiation
Teven, C. M., Liu, X., Hu, N., Tang, N., Kim, S. H., Huang, E., Yang, K., Li, M., Gao, J., Liu, H., et al. (2011) · Stem Cells International · doi:10.4061/2011/201371 · Cited by 130
DNA Methylation and Chromatin Structure Regulate T Cell Perforin Gene Expression
Lu, Q., Wu, A., Ray, D., Deng, C., Attwood, J., Hanash, S., Pipkin, M. E., Lichtenheld, M. G., & Richardson, B. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5124 · Cited by 128
DNA Methylation from Embryo to Adult
Razin, A., & Kafri, T. (1994) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(08)60853-3 · Cited by 129
5-Methylcytosine DNA Demethylation: More Than Losing a Methyl Group
Franchini, D., Schmitz, K.-M., & Petersen‐Mahrt, S. K. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110711-155451 · Cited by 133
Epigenetic regulation in development: is the mouse a good model for the human?
Hanna, C. W., Demond, H., & Kelsey, G. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy021 · Cited by 131
The CcrM DNA methyltransferase is widespread in the alpha subdivision of proteobacteria, and its essential functions are conserved in Rhizobium meliloti and Caulobacter crescentus
Wright, R., Stephens, C. M., & Shapiro, L. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.18.5869-5877.1997 · Cited by 127
Epigenetic regulation of the expression of genes involved in steroid hormone biosynthesis and action
Martinez-Arguelles, D. B., & Papadopoulos, V. (2010) · Steroids · doi:10.1016/j.steroids.2010.02.004 · Cited by 130
Connections between epigenetic gene silencing and human disease
Moss, T. J. M., & Wallrath, L. L. (2007) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2006.05.038 · Cited by 128
Expression of mRNAs for DNA methyltransferases and methyl‐CpG‐binding proteins in the human female germ line, preimplantation embryos, and embryonic stem cells
Huntriss, J., Hinkins, M., Oliver, B. G. G., Harris, S. E., Beazley, J., Rutherford, A. J., Gosden, R. G., Lanzendorf, S. E., & Picton, H. M. (2004) · Molecular Reproduction and Development · doi:10.1002/mrd.20030 · Cited by 129
DNA methylation and Rett syndrome
Kriaučionis, S., & Bird, A. P. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg286 · Cited by 128
Revisiting the genomic hypomethylation hypothesis of aging
Unnikrishnan, A., Hadad, N., Masser, D. R., Jackson, J., Freeman, W. M., & Richardson, A. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13533 · Cited by 113
Nucleic Acid Oxidation in DNA Damage Repair and Epigenetics
Zheng, G., Fu, Y., & He, C. (2014) · Chemical Reviews · doi:10.1021/cr400432d · Cited by 131
Salt Tolerant and Sensitive Rice Varieties Display Differential Methylome Flexibility under Salt Stress
Ferreira, L. J., Azevedo, V., Marôco, J. P., Oliveira, M. M., & Santos, A. P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124060 · Cited by 126
Role of Epigenetics in Cardiac Development and Congenital Diseases
Moore‐Morris, T., Vliet, P. P. V., Andelfinger, G., & Pucéat, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00048.2017 · Cited by 133
The role and mechanisms of DNA methylation in the oocyte
Sendžikaitė, G., & Kelsey, G. (2019) · Essays in Biochemistry · doi:10.1042/ebc20190043 · Cited by 133
Methylation and demethylation in the regulation of genes, cells, and responses in the immune system
Fitzpatrick, D. R., & Wilson, C. B. (2003) · Clinical Immunology · doi:10.1016/s1521-6616(03)00205-5 · Cited by 128
Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection
Wang, Z., Kiefer, F., Urbánek, P., & Wagner, E. F. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00655-2 · Cited by 126
Formation of nucleoprotein filaments by mammalian DNA methyltransferase Dnmt3a in complex with regulator Dnmt3L
Jurkowska, R. Z., Anspach, N., Urbanke, C., Jia, D., Reinhardt, R., Nellen, W., Cheng, X., & Jeltsch, A. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn747 · Cited by 126
Abnormal Chromosome Behavior in Neurospora Mutants Defective in DNA Methylation
Foss, H. M., Roberts, C. J., Claeys, K. M., & Selker, E. U. (1993) · Science · doi:10.1126/science.7505062 · Cited by 128
Dynamics of DNA methylation during development
Brandeis, M., Ariel, M., & Cedar, H. (1993) · BioEssays · doi:10.1002/bies.950151103 · Cited by 129
Targeted disruption of Col8a1 and Col8a2 genes in mice leads to anterior segment abnormalities in the eye
Hopfer, U., Fukai, N., Hopfer, H., Wolf, G., Joyce, N. C., Li, E., & Olsen, B. R. (2005) · The FASEB Journal · doi:10.1096/fj.04-3019com · Cited by 125
Self-citation
DNA Methylation Density Influences the Stability of an Epigenetic Imprint and Dnmt3a/b-Independent De Novo Methylation
Lorincz, M. C., Schübeler, D., Hutchinson, S. R., Dickerson, D. R., & Groudine, M. T. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7572-7580.2002 · Cited by 125
Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells
Agarwal, S., Amin, K. S., Jagadeesh, S., Baishay, G., Rao, P. G., Barua, N. C., Bhattacharya, S., & Banerjee, P. P. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-99 · Cited by 125
Evolving insights on how cytosine methylation affects protein-DNA binding
Dantas Machado, A. C., Zhou, T., Rao, S., Goel, P., Rastogi, C., Lazarovici, A., Bussemaker, H. J., & Rohs, R. (2015) · Briefings in Functional Genomics · doi:10.1093/bfgp/elu040 · Cited by 124
Epigenetic remodeling during arsenical-induced malignant transformation
Jensen, T. J., Novák, P., Eblin, K. E., Gandolfi, A. J., & Futscher, B. W. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn102 · Cited by 127
apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes.
Huang, L., Voyiaziakis, E., Markenson, D. F., Sokol, K. A., Hayek, T., & Breslow, J. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118269 · Cited by 124
Genomic Imprinting and Epigenetic Control of DevelopmentPreprint
Fedoriw, A., Mugford, J., & Magnuson, T. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008136 · Cited by 123
Global DNA Hypomethylation in Peripheral Blood Leukocytes as a Biomarker for Cancer Risk: A Meta-Analysis
Woo, H. D., & Kim, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034615 · Cited by 123
DNA methylation 40 years later: Its role in human health and disease
Scarano, M. I., Strazzullo, M., Matarazzo, M. R., & D'Esposito, M. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20280 · Cited by 121
Yeast as a model system for anticancer drug discovery
Simon, J. A., & Bedalov, A. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1372 · Cited by 125
A proximal conserved repeat in theXistgene is essential as a genomic element for X-inactivation in mouse
Hoki, Y., Kimura, N., Kanbayashi, M., Amakawa, Y., Ohhata, T., Sasaki, H., & Sado, T. (2008) · Development · doi:10.1242/dev.026427 · Cited by 122
Asynchronous replication timing of imprinted loci is independent of DNA methylation, but consistent with differential subnuclear localization.Preprint
Gribnau, J., Hochedlinger, K., Hata, K., Li, E., & Jaenisch, R. (2003) · Genes & Development · doi:10.1101/gad.1059603 · Cited by 128
Self-citation
DNA Methylation and Demethylation as Targets for Anticancer Therapy
Szyf, M. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0147-7 · Cited by 121
Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development
Żylicz, J. J., Dietmann, S., Günesdogan, U., Hackett, J. A., Cougot, D., Lee, C. G. L., & Surani, M. A. (2015) · eLife · doi:10.7554/elife.09571 · Cited by 123
Regulation of DNA methylation turnover at LTR retrotransposons and imprinted loci by the histone methyltransferase Setdb1
Leung, D., Du, T., Wagner, U., Xie, W., Lee, A. Y., Goyal, P., Li, Y., Szulwach, K. E., Jin, P., Lorincz, M. C., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322273111 · Cited by 125
Metabolism and Epigenetic Interplay in Cancer: Regulation and Putative Therapeutic Targets
Miranda‐Gonçalves, V., Lameirinhas, A., Henrique, R., & Jerónimo, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00427 · Cited by 125
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders
Jönsson, M. E., Garza, R., Johansson, P. A., & Jakobsson, J. (2020) · Trends in Genetics · doi:10.1016/j.tig.2020.05.004 · Cited by 122
Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibians
Yakushiji‐Kaminatsui, N., Suzuki, M., Satoh, A., Sagai, T., Shiroishi, T., Kobayashi, H., Sasaki, H., Ide, H., & Tamura, K. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.022 · Cited by 123
Chromatin and siRNA pathways cooperate to maintain DNA methylation of small transposable elements in Arabidopsis
Tran, R. K., Zilberman, D., de Bustos, C., Ditt, R. F., Henikoff, J. G., Lindroth, A. M., Delrow, J. J., Boyle, T., Kwong, S., Bryson, T. D., et al. (2005) · Genome biology · doi:10.1186/gb-2005-6-11-r90 · Cited by 124
Gene Silencing by Methyl‐CPG‐Binding Proteins
Nan, X., Cross, S. H., & Bird, A. P. (2007) · Novartis Foundation symposium · doi:10.1002/9780470515501.ch2 · Cited by 127
Molecular Pathogenesis of Hepatocellular Carcinoma
Ho, D. W., Lo, R. C., Chan, L., & Ng, I. O. (2016) · Liver Cancer · doi:10.1159/000449340 · Cited by 122
Global changes in genomic methylation levels during early development of the zebrafish embryo
Mhanni, A. A., & McGowan, R. A. (2004) · Development Genes and Evolution · doi:10.1007/s00427-004-0418-0 · Cited by 121
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes
Clements, E. G., Mohammad, H. P., Leadem, B. R., Easwaran, H., Cai, Y., Neste, L. V., & Baylin, S. B. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks031 · Cited by 121
Dynamic expression of DNMT3a and DNMT3b isoforms during male germ cell development in the mouse
Salle, S. L., & Trasler, J. M. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.04.436 · Cited by 135
Status of genomic imprinting in human embryonic stem cells as revealed by a large cohort of independently derived and maintained lines
Rugg‐Gunn, P. J., Ferguson‐Smith, A. C., & Pedersen, R. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm245 · Cited by 121
Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development
Ikegami, K., Ohgane, J., Tanaka, S., Yagi, S., & Shiota, K. (2009) · The International Journal of Developmental Biology · doi:10.1387/ijdb.082741ki · Cited by 122
Automated maintenance of embryonic stem cell cultures
Terstegge, S., Laufenberg, I., Pochert, J., Schenk, S., Itskovitz‐Eldor, J., Endl, E., & Brüstle, O. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.21061 · Cited by 120
Mammalian DNA methyltransferases.
Siedlecki, P. S., & Zielenkiewicz, P. (2006) · Acta Biochimica Polonica · doi:10.18388/abp.2006_3337 · Cited by 122
Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation
Calvopina, J. H., Taylor, S. K., Cook, H., Hu, Z., Lee, S. A., Yen, M., Chiang, Y., Chen, P., & Clark, A. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.07.019 · Cited by 126
DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse
Zhou, W., Hinoue, T., Barnes, B., Mitchell, O. D., Iqbal, W., Lee, S. M., Foy, K. K., Lee, K., Moyer, E. J., VanderArk, A., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100144 · Cited by 116
Rapid Cerebral Ischemic Preconditioning in Mice Deficient in Endothelial and Neuronal Nitric Oxide Synthases
Atochin, D. N., Clark, J. W., It, D., Moskowitz, M. A., & Huang, P. L. (2003) · Stroke · doi:10.1161/01.str.0000066870.70976.57 · Cited by 119
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation
Dodge, J. E., Ramsahoye, B. H., Wo, Z. G., Okano, M., & Li, E. (2002) · Gene · doi:10.1016/s0378-1119(02)00469-9 · Cited by 120
Self-citation
DNA methylation in eukaryotes
Martienssen, R. A. (1995) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(95)80014-x · Cited by 118
Molecular Links between X-Inactivation and Autosomal Imprinting: X-Inactivation as a Driving Force for the Evolution of Imprinting?
Lee, J. T. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00162-3 · Cited by 121
In utero alcohol exposure, epigenetic changes, and their consequences
Ungerer, M. (2013) · Alcohol research · doi:10.35946/arcr.v35.1.05 · Cited by 123
Epigenetic dynamics during preimplantation development
Marcho, C., Cui, W., & Mager, J. (2015) · Reproduction · doi:10.1530/rep-15-0180 · Cited by 120
Diagnosis of Bladder Cancer Recurrence Based on Urinary Levels of EOMES, HOXA9, POU4F2, TWIST1, VIM, and ZNF154 Hypermethylation
Reinert, T., Borre, M., Christiansen, A., Hermann, G. G., Orntoft, T. F., & Dyrskjøt, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046297 · Cited by 121
Differential repetitive DNA methylation in multiple myeloma molecular subgroups
Bollati, V., Fabris, S., Pegoraro, V., Ronchetti, D., Mosca, L., Deliliers, G. L., Motta, V., Bertazzi, P. A., Baccarelli, A., & Neri, A. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp149 · Cited by 121
B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
Barwick, B. G., Scharer, C. D., Martinez, R. J., Price, M. J., Wein, A. N., Haines, R. R., Bally, A. P. R., Kohlmeier, J. E., & Boss, J. M. (2018) · Nature Communications · doi:10.1038/s41467-018-04234-4 · Cited by 128
The Epigenetics of Colorectal Cancer
Issa, J. J. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06706.x · Cited by 119
The Expanding Role of Epigenetics in the Development, Diagnosis and Treatment of Prostate Cancer and Benign Prostatic Hyperplasia
Dobosy, J. R., Roberts, J. L., Fu, V. X., & Jarrard, D. F. (2007) · The Journal of Urology · doi:10.1016/j.juro.2006.10.063 · Cited by 118
Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain
Lee, J. T., Lu, N., & Han, Y.-C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.3836 · Cited by 118
piRNA and spermatogenesis in mice
Chuma, S., & Nakano, T. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0338 · Cited by 125
Epigenetic Switch Driven by DNA Inversions Dictates Phase Variation in Streptococcus pneumoniae
Li, J., Li, J., Feng, Z., Wang, J., An, H., Liu, Y., Wang, Y., Wang, K., Zhang, X., Miao, Z., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005762 · Cited by 111
Atherosclerosis and flow: roles of epigenetic modulation in vascular endothelium
Lee, D.-Y., & Chiu, J. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0551-8 · Cited by 120
Epigenetic gene regulation in plants and its potential applications in crop improvement
Zhang, H., & Zhu, J. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00769-1 · Cited by 118
Coordinate regulation of DNA methyltransferase expression during oogenesis
Lucifero, D., Salle, S. L., Bourc’his, D., Martel, J., Bestor, T. H., & Trasler, J. M. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-36 · Cited by 123
Self-citation
Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis
Clark, S. J. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm051 · Cited by 118
Epigenetics and developmental programming of welfare and production traits in farm animals
Sinclair, K. D., Rutherford, K., Wallace, J. M., Brameld, J. M., Stöger, R. J., Alberio, R., Sweetman, D., Gardner, D. S., Perry, V. E. A., Adam, C. L., et al. (2016) · Reproduction Fertility and Development · doi:10.1071/rd16102 · Cited by 124
DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation
Ren, W., Fan, H., Grimm, S. A., Kim, J. J., Li, L., Guo, Y., Petell, C. J., Tan, X.-F., Zhang, Z., Coan, J. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22665-4 · Cited by 124
Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects
Chang, H., Zhang, T., Zhang, Z., Bao, R., Fu, C., Wang, Z., Bao, Y., Li, Y., Wu, L., Zheng, X., et al. (2011) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2010.10.003 · Cited by 117
CXXC Domain of Human DNMT1 Is Essential for Enzymatic Activity
Pradhan, M., Estève, P., Chin, H. G., Samaranayke, M., Kim, G., & Pradhan, S. (2008) · Biochemistry · doi:10.1021/bi8011725 · Cited by 125
Novel pycnodysostosis mouse model uncovers cathepsin K function as a potential regulator of osteoclast apoptosis and senescence
Chen, W., Yang, S., Abe, Y., Li, M., Wang, Y., Shao, J., Li, E., & Li, Y. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddl474 · Cited by 120
Self-citation
Elevated mRNA levels of DNA methyltransferase‐1 as an independent prognostic factor in primary nonsmall cell lung cancer
Kim, H., Kwon, Y. M., Kim, J. S., Han, J., Shim, Y. M., Park, J., & Kim, D. (2006) · Cancer · doi:10.1002/cncr.22087 · Cited by 117
Kaiso is a genome-wide repressor of transcription that is essential for amphibian development
Ruzov, A. S., Dunican, D. S., Prokhortchouk, A., Pennings, S., Stancheva, I., Prokhortchouk, E., & Meehan, R. R. (2004) · Development · doi:10.1242/dev.01549 · Cited by 122
CpG Island of Rat Sphingosine Kinase-1 Gene: Tissue-Dependent DNA Methylation Status and Multiple Alternative First Exons
Imamura, T., Ohgane, J., Ito, S., Ogawa, T., Hattori, N., Tanaka, S., & Shiota, K. (2001) · Genomics · doi:10.1006/geno.2001.6607 · Cited by 117

Authors: Li, E., Bestor, T. H., & Jaenisch, R.
Affiliations: Whitehead Institute for Biomedical Research (US)
Harvard University (US)
ORCID: Li, En
Bestor, Timothy H.
Jaenisch, Rudolf
Venue: Cell
Publisher: Elsevier BV
Published: 1992-06
Volume: 69
Issue: 6
Pages: 915-926
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(92)90611-f
OpenAlex: W2046241907
Cited by: 3,984
References: 61
Citations by year: 2026: 50 · 2025: 60 · 2024: 81 · 2023: 84 · 2022: 84 · 2021: 90 · 2020: 95 · 2019: 127 · 2018: 137 · 2017: 113 · 2016: 147 · 2015: 157 · 2014: 169 · 2013: 178 · 2012: 187
FWCI: 28.04
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r35ca044339-13, 5r01gm043565-04)
National Cancer Institute (R35 CA 44339-05)
National Institute of General Medical Sciences (GM-43565)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Keywords: DNA methyltransferases, embryonic lethality, DNA methylation, 5-methylcytosine, demethylation, embryonic stem cells, germline mutations, recessive lethality, mouse embryo development, gene targeting
MeSH terms: Animals, Chimera, DNA, DNA (Cytosine-5-)-Methyltransferases, Genes, Lethal, Homozygote, Methylation, Stem Cells, Blotting, Western, Mutagenesis, Insertional, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks