The DOI matches its Crossref record; 59 of the 61 references it cites were found in a registry or an index.
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Abstract
Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA methyltransferase gene. ES cell lines homozygous for the mutation were generated by consecutive targeting of both wild-type alleles; the mutant cells were viable and showed no obvious abnormalities with respect to growth rate or morphology, and had only trace levels of DNA methyltransferase activity. A quantitative end-labeling assay showed that the level of m5C in the DNA of homozygous mutant cells was about one-third that of wild-type cells, and Southern blot analysis after cleavage of the DNA with a methylation-sensitive restriction endonuclease revealed substantial demethylation of endogenous retroviral DNA. The mutation was introduced into the germline of mice and found to cause a recessive lethal phenotype. Homozygous embryos were stunted, delayed in development, and did not survive past mid-gestation. The DNA of homozygous embryos showed a reduction of the level of m5C similar to that of homozygous ES cells. These results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Global deletion of mouse Dnmt1, Dnmt3b, or both Dnmt3a + Dnmt3b results in midgestation lethality [gestational day (GD) 9.5–11.5], while deletion of only Dnmt3a produces severe growth retardation and lethality by 4 weeks of age [ 70–72 ].”
From DNA methylation: a mechanism linking environmental chemical exposures to risk of autism spectrum disorders? (2016) · cites this paper as [70]
Citations
Cites
Wessel, D., & Flügge, U. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90782-6 · Cited by 3,997
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells
Thomas, K. R., & Capecchi, M. R. (1987) · Cell · doi:10.1016/0092-8674(87)90646-5 · Cited by 2,355
Altering the Genome by Homologous Recombination
Capecchi, M. R. (1989) · Science · doi:10.1126/science.2660260 · Cited by 2,037
Mansour, S. L., Thomas, K. R., & Capecchi, M. R. (1988) · Nature · doi:10.1038/336348a0 · Cited by 1,683
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,519
Simplified mammalian DNA isolation procedure
Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R., & Berns, A. J. M. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.15.4293 · Cited by 1,497
Self-citationX inactivation, differentiation, and DNA methylation
Riggs, A. D. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000130315 · Cited by 1,343
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Tybulewicz, V. L. J., Crawford, C. E., Jackson, P. K., Bronson, R. T., & Mulligan, R. C. (1991) · Cell · doi:10.1016/0092-8674(91)90011-m · Cited by 1,281
Monk, M., Boubelı́k, M., & Lehnert, S. A. (1987) · Development · doi:10.1242/dev.99.3.371 · Cited by 1,100
Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells
Bestor, T. H., Laudano, A. P., Mattaliano, R. J., & Ingram, V. M. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90122-2 · Cited by 913
Self-citation
Cited by
Sorted by citations
Items 101–200 of 1,016
Robertson, K. D., Uzvölgyi, É., Liang, G., Talmadge, C. B., Sümegi, J., Gonzales, F. A., & Jones, P. A. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.11.2291 · Cited by 868
Induced Pluripotent Stem Cells: Past, Present, and Future
Yamanaka, S. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.005 · Cited by 878
DNA Methylation Signatures Identify Biologically Distinct Subtypes in Acute Myeloid Leukemia
Figueroa, M. E., Lugthart, S., Li, Y., Erpelinck-Verschueren, C. A. J., Deng, X., Christos, P. J., Schifano, E. D., Booth, J. G., van Putten, W., Skrabanek, L. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.11.020 · Cited by 849
Tsix, a gene antisense to Xist at the X-inactivation centre
Lee, J. T., Davidow, L. S., & Warshawsky, D. (1999) · Nature Genetics · doi:10.1038/7734 · Cited by 816
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture
Young, L. E., Fernandes, K., McEvoy, T. G., Butterwith, S. C., Gutiérrez, C. G., Carolan, C., Broadbent, P. J., Robinson, J. J., Wilmut, I., & Sinclair, K. D. (2001) · Nature Genetics · doi:10.1038/84769 · Cited by 830
Induced pluripotency: history, mechanisms, and applicationsPreprint
Stadtfeld, M., & Hochedlinger, K. (2010) · Genes & Development · doi:10.1101/gad.1963910 · Cited by 857
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
Wang, J., Hevi, S., Kurash, J. K., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G., et al. (2008) · Nature Genetics · doi:10.1038/ng.268 · Cited by 827
Self-citationThe many faces of histone lysine methylation
Lachner, M., & Jenuwein, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00335-6 · Cited by 832
DNA Methylation: Superior or Subordinate in the Epigenetic Hierarchy?
Jin, B., Li, Y., & Robertson, K. D. (2011) · Genes & Cancer · doi:10.1177/1947601910393957 · Cited by 868
De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells
Lei, H., Oh, S. P., Okano, M., Jüttermann, R., Goss, K. A., Jaenisch, R., & Li, E. (1996) · Development · doi:10.1242/dev.122.10.3195 · Cited by 816
Self-citationMi-2 complex couples DNA methylation to chromatin remodelling and histone deacetylation
Wade, P. A., Gégonne, A., Jones, P. L., Ballestar, E., Aubry, F., & Wolffe, A. P. (1999) · Nature Genetics · doi:10.1038/12664 · Cited by 811
Cortellino, S., Xu, J., Sannai, M., Moore, R., Caretti, E., Cigliano, A., Le Coz, M., Devarajan, K., Wessels, A., Soprano, D., et al. (2011) · Cell · doi:10.1016/j.cell.2011.06.020 · Cited by 809
Ernfors, P., Lee, K., Kučera, J., & Jaenisch, R. (1994) · Cell · doi:10.1016/0092-8674(94)90213-5 · Cited by 813
Self-citationEpigenetic inheritance during the cell cycle
Probst, A. V., Dunleavy, E. M., & Almouzni, G. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2640 · Cited by 857
Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II
Schoeftner, S., & Blasco, M. A. (2007) · Nature Cell Biology · doi:10.1038/ncb1685 · Cited by 828
Maternal Methyl Supplements in Mice Affect Epigenetic Variation and DNA Methylation of Offspring
Cooney, C. A., Dave, A. A., & Wolff, G. L. (2002) · Journal of Nutrition · doi:10.1093/jn/132.8.2393s · Cited by 784
Weinstein, D. C., Altaba, A. R. I., Chen, W. S., Hoodless, P. A., Prezioso, V. R., Jessell, T. M., & Darnell, J. E., Jr. (1994) · Cell · doi:10.1016/0092-8674(94)90523-1 · Cited by 783
Waterland, R. A., & Jirtle, R. L. (2003) · Nutrition · doi:10.1016/j.nut.2003.09.011 · Cited by 790
Fujiwara, Y., Browne, C. P., Cunniff, K., Goff, S. C., & Orkin, S. H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12355 · Cited by 778
Rethinking how DNA methylation patterns are maintained
Jones, P. A., & Liang, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2651 · Cited by 799
The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase
Fuks, F. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg332 · Cited by 799
Altered microtubule organization in small-calibre axons of mice lacking tau protein
Harada, A., Oguchi, K., Okabe, S., Kuno, J., Terada, S., Ohshima, T., Sato-Yoshitake, R., Takei, Y., Noda, T., & Hirokawa, N. (1994) · Nature · doi:10.1038/369488a0 · Cited by 802
Valinluck, V. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh739 · Cited by 756
E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation
Field, S. J., Tsai, F., Kuo, F. C., Zubiaga, A. M., Kaelin, W. G., Livingston, D. M., Orkin, S. H., & Greenberg, M. E. (1996) · Cell · doi:10.1016/s0092-8674(00)81255-6 · Cited by 754
Haziot, A., Ferrero, E., Köntgen, F., Hijiya, N., Yamamoto, S., Silver, J. E., Stewart, C. L., & Goyert, S. M. (1996) · Immunity · doi:10.1016/s1074-7613(00)80254-x · Cited by 732
Chromatin structure and the inheritance of epigenetic information
Margueron, R., & Reinberg, D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2752 · Cited by 761
The colorectal adenoma–carcinoma sequence
Leslie, A., CAREY, F. A., Pratt, N. R., & Steele, R. J. (2002) · British journal of surgery · doi:10.1046/j.1365-2168.2002.02120.x · Cited by 771
Murine FGFR-1 is required for early postimplantation growth and axial organization.Preprint
Deng, C.-X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D., & Leder, P. (1994) · Genes & Development · doi:10.1101/gad.8.24.3045 · Cited by 775
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P. R., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., et al. (2013) · Cell · doi:10.1016/j.cell.2013.04.022 · Cited by 739
Effects of DNA methylation on DNA-binding proteins and gene expression
Tate, P. H., & Bird, A. P. (1993) · Current Opinion in Genetics & Development · doi:10.1016/0959-437x(93)90027-m · Cited by 737
DNA methylation, methyltransferases, and cancer
Robertson, K. D. (2001) · Oncogene · doi:10.1038/sj.onc.1204341 · Cited by 746
Xist-deficient mice are defective in dosage compensation but not spermatogenesis.Preprint
Marahrens, Y., Panning, B., Dausman, J. A., Strauss, W. M., & Jaenisch, R. (1997) · Genes & Development · doi:10.1101/gad.11.2.156 · Cited by 724
Self-citationThe DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome
Hansen, R. S., Wijmenga, C., Luo, P., Stanek, A. M., Canfield, T. K., Weemaes, C. M. R., & Gartler, S. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14412 · Cited by 743
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryosPreprint
Messerschmidt, D. M., Knowles, B. B., & Solter, D. (2014) · Genes & Development · doi:10.1101/gad.234294.113 · Cited by 762
Female infertility in mice lacking connexin 37
Simon, A. M., Goodenough, D. A., Li, E., & Paul, D. L. (1997) · Nature · doi:10.1038/385525a0 · Cited by 736
Self-citationChae, T., Kwon, Y. T., Bronson, R., Dikkes, P., Li, E., & Tsai, L.-H. (1997) · Neuron · doi:10.1016/s0896-6273(01)80044-1 · Cited by 715
Self-citationAlpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis
Kreidberg, J. A., Donovan, M. J., Goldstein, S. L., Rennke, H. G., Shepherd, K. E., Jones, R. C., & Jaenisch, R. (1996) · Development · doi:10.1242/dev.122.11.3537 · Cited by 731
Self-citationMolecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
Liu, C., Weaver, D. R., Jin, X., Shearman, L. P., Pieschl, R. L., Gribkoff, V. K., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80350-5 · Cited by 723
Differential Effects of Culture on Imprinted H19 Expression in the Preimplantation Mouse Embryo1
Doherty, A. S., Mann, M. R. W., Tremblay, K. D., Bartolomei, M. S., & Schultz, R. M. (2000) · Biology of Reproduction · doi:10.1095/biolreprod62.6.1526 · Cited by 723
Reduced DNA methylation in Arabidopsis thaliana results in abnormal plant development.
Finnegan, E. J., Peacock, W. J., & Dennis, E. S. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8449 · Cited by 720
Suppression of intestinal neoplasia by DNA hypomethylation
Laird, P. W., Jackson‐Grusby, L., Fazeli, A., Dickinson, S., Jung, W. E., Li, E., Weinberg, R. A., & Jaenisch, R. (1995) · Cell · doi:10.1016/0092-8674(95)90329-1 · Cited by 707
Self-citationBraun, T. W., Rudnicki, M. A., Arnold, H.-H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90507-9 · Cited by 702
Self-citationLoss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation
Jackson-Grusby, L., Beard, C., Possemato, R., Tudor, M., Fambrough, D., Csankovszki, G., Dausman, J., Lee, P., Wilson, C., Lander, E., et al. (2001) · Nature Genetics · doi:10.1038/83730 · Cited by 694
Self-citationGenomic Imprinting in MammalsPreprint
Barlow, D. P., & Bartolomei, M. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018382 · Cited by 752
Arabidopsis thaliana DNA Methylation Mutants
Vongs, A., Kakutani, T., Martienssen, R. A., & Richards, E. J. (1993) · Science · doi:10.1126/science.8316832 · Cited by 717
Maintenance of genomic methylation requires a SWI2/SNF2-like protein
Jeddeloh, J. A., Stokes, T. L., & Richards, E. J. (1999) · Nature Genetics · doi:10.1038/8803 · Cited by 705
Structure and Function of Mammalian DNA Methyltransferases
Jurkowska, R. Z., Jurkowski, T. P., & Jeltsch, A. (2010) · ChemBioChem · doi:10.1002/cbic.201000195 · Cited by 725
Shivdasani, R. A., Rosenblatt, M., Zucker‐Franklin, D., Jackson, C. W., Hunt, P., Saris, C. J. M., & Orkin, S. H. (1995) · Cell · doi:10.1016/0092-8674(95)90531-6 · Cited by 700
Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene
Howell, C. Y., Bestor, T. H., Ding, F., Latham, K. E., Mertineit, C., Trasler, J. M., & Chaillet, J. R. (2001) · Cell · doi:10.1016/s0092-8674(01)00280-x · Cited by 708
Self-citationGenetic variation among 129 substrains and its importance for targeted mutagenesis in mice
Simpson, E. M., Linder, C. C., Sargent, E. E., Davisson, M. T., Mobraaten, L. E., & Sharp, J. J. (1997) · Nature Genetics · doi:10.1038/ng0597-19 · Cited by 684
Gutstein, D. E., Morley, G. E., Tamaddon, H. S., Vaidya, D. M., Schneider, M. D., Chen, J., Chien, K. R., Stuhlmann, H., & Fishman, G. I. (2001) · Circulation Research · doi:10.1161/01.res.88.3.333 · Cited by 680
Jüttermann, R., Li, E., & Jaenisch, R. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.25.11797 · Cited by 679
Self-citationShivdasani, R. A., Fujiwara, Y., McDevitt, M. A., & Orkin, S. H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3965 · Cited by 671
Chen, T., Ueda, Y., Dodge, J. E., Wang, Z., & Li, E. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5594-5605.2003 · Cited by 751
Self-citationMechanisms and functions of Tet protein-mediated 5-methylcytosine oxidationPreprint
Wu, H., & Zhang, Y. (2011) · Genes & Development · doi:10.17615/800j-yk16 · Cited by 686
Jones, P. A. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(98)01636-9 · Cited by 665
Cbfa2 is required for the formation of intra-aortic hematopoietic clusters
North, T., Gu, T.-L., Stacy, T., Wang, Q., Howard, L., Binder, M., Marín-Padilla, M., & Speck, N. A. (1999) · Development · doi:10.1242/dev.126.11.2563 · Cited by 662
Genetic and Epigenetic Regulators of Pluripotency
Surani, M. A., Hayashi, K., & Hájková, P. (2007) · Cell · doi:10.1016/j.cell.2007.02.010 · Cited by 676
Role of CYP2E1 in the Hepatotoxicity of Acetaminophen
Lee, S. S. T., Buters, J., Pineau, T., Fernández‐Salguero, P. M., & Gonzalez, F. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12063 · Cited by 655
Recombinant Human DNA (Cytosine-5) Methyltransferase
Pradhan, S., Bacolla, A., Wells, R. D., & Roberts, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33002 · Cited by 677
Hayashi, K., Lopes, S. M. C. D. S., Tang, F., & Surani, M. A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.027 · Cited by 649
Methylation determines fibroblast activation and fibrogenesis in the kidney
Bechtel‐Walz, W., McGoohan, S., Zeisberg, E. M., Muller, G. A., Kalbacher, H., Salant, D. J., Müller, C. A., Kalluri, R., & Zeisberg, M. (2010) · Nature Medicine · doi:10.1038/nm.2135 · Cited by 655
RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis.Preprint
Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R., & Evans, R. M. (1994) · Genes & Development · doi:10.1101/gad.8.9.1007 · Cited by 644
A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci
Illingworth, R. S., Kerr, A. R. W., DeSousa, D., Jørgensen, H. F., Ellis, P., Stalker, J., Jackson, D. K., Clee, C. M., Plumb, R. W., Rogers, J., et al. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060022 · Cited by 663
DNA Methylation of the First Exon Is Tightly Linked to Transcriptional Silencing
Brenet, F. A., Moh, M., Funk, P., Feierstein, E., Viale, A. J., Socci, N. D., & Scandura, J. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014524 · Cited by 654
Epigenetic interplay between histone modifications and DNA methylation in gene silencing
Vaissière, T., Sawan, C., & Herceg, Z. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.02.004 · Cited by 657
Bartolomei, M. S., & Tilghman, S. M. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.493 · Cited by 633
Coxon, A., Rieu, P., Barkalow, F. J., Askari, S., Sharpe, A. H., von Andrian, U. H., Arnaout, M. A., & Mayadas, T. N. (1996) · Immunity · doi:10.1016/s1074-7613(00)80278-2 · Cited by 627
Cre-lox-regulated conditional RNA interference from transgenes
Ventura, A., Meissner, A., Dillon, C. P., McManus, M. T., Sharp, P. A., Parijs, L. V., Jaenisch, R., & Jacks, T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403954101 · Cited by 623
Self-citationThe CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo
Wang, Q., Stacy, T., Miller, J. D., Lewis, A. F., Gu, T.-L., Huang, X., Bushweller, J. H., Bories, J.-C., Alt, F. W., Ryan, G., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81389-6 · Cited by 621
Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense
Vasu, K., & Nagaraja, V. (2013) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00044-12 · Cited by 639
PERSPECTIVE: TRANSPOSABLE ELEMENTS, PARASITIC DNA, AND GENOME EVOLUTION
KIDWELL, M. G., & Lisch, D. R. (2001) · Evolution · doi:10.1111/j.0014-3820.2001.tb01268.x · Cited by 621
A mammalian protein with specific demethylase activity for mCpG DNA
Bhattacharya, S. K., Ramchandani, S., Cervoni, N., & Moshe Szyf, A. (1999) · Nature · doi:10.1038/17533 · Cited by 616
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
Robert, M., Morin, S., Beaulieu, N., Gauthier, F., Chute, I. C., Barsalou, A., & MacLeod, A. R. (2002) · Nature Genetics · doi:10.1038/ng1068 · Cited by 615
Liu, X., Wu, H., Byrne, M., Krane, S., & Jaenisch, R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1852 · Cited by 614
Self-citationA New Family of β-Hairpin Mimetics Based on a Trypsin Inhibitor from Sunflower Seeds
Descours, A., Moehle, K., Renard, A., & Robinson, J. A. (2002) · ChemBioChem · doi:10.1002/1439-7633(20020402)3:4 · Cited by 68
Arabidopsis MET1 Cytosine Methyltransferase Mutants
Kankel, M. W., Ramsey, D. E., Stokes, T. L., Flowers, S. K., Haag, J. R., Jeddeloh, J. A., Riddle, N. C., Verbsky, M. L., & Richards, E. J. (2003) · Genetics · doi:10.1093/genetics/163.3.1109 · Cited by 613
Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice
Xu, T., Bianco, P., Fisher, L. W., Longenecker, G., Smith, E. A., Goldstein, S. A., Bonadio, J. F., Boskey, A. L., Heegaard, A., Sommer, B., et al. (1998) · Nature Genetics · doi:10.1038/1746 · Cited by 614
Chen, Z. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.5.433 · Cited by 612
DNA methylation: past, present and future directions
Robertson, K. D., & Jones, P. A. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.461 · Cited by 613
Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes
Wu, H., Coskun, V., Tao, J., Xie, W., Ge, W., Yoshikawa, K., Li, E., Zhang, Y., & Sun, Y. E. (2010) · Science · doi:10.1126/science.1190485 · Cited by 604
Self-citationVidal, S., Tremblay, M. L., Govoni, G., Gauthier, S., Sebastiani, G., Malo, D., Skamene, E., Olivier, M., Jothy, S., & Gros, P. (1995) · The Journal of experimental medicine · doi:10.1084/jem.182.3.655 · Cited by 603
DNA methyltransferases control telomere length and telomere recombination in mammalian cells
Gonzalo, S., Jaco, I., Fraga, M. F., Chen, T., Li, E., Esteller, M., & Blasco, M. A. (2006) · Nature Cell Biology · doi:10.1038/ncb1386 · Cited by 544
Self-citationLethal β-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF
Parkins, A. C., Sharpe, A. H., & Orkin, S. H. (1995) · Nature · doi:10.1038/375318a0 · Cited by 599
Smet, C. D., Lurquin, C., Lethé, B., Martelange, V., & Boon, T. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.11.7327 · Cited by 612
Smad2 role in mesoderm formation, left–right patterning and craniofacial development
Nomura, M., & Li, E. (1998) · Nature · doi:10.1038/31693 · Cited by 597
Self-citationA tale of three fingers: the family of mammalian Sp/XKLF transcription factors
Philipsen, S., & Suske, G. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.15.2991 · Cited by 595
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
Accili, D., Drago, J., Lee, E. J., Johnson, M. D., Cool, M. H., Salvatore, P., Asico, L. D., José, P. A., Taylor, S. I., & Westphal, H. (1996) · Nature Genetics · doi:10.1038/ng0196-106 · Cited by 594
DNA methylation dynamics in health and disease
Bergman, Y., & Cedar, H. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2518 · Cited by 592
FGF5 as a regulator of the hair growth cycle: Evidence from targeted and spontaneous mutations
Hébert, J. M., Rosenquist, T., Götz, J., & Martin, G. R. (1994) · Cell · doi:10.1016/0092-8674(94)90276-3 · Cited by 589
Semaphorin III is needed for normal patterning and growth of nerves, bones and heart
Behar, O., Golden, J. A., Mashimo, H. L., Schöen, F. J., & Fishman, M. C. (1996) · Nature · doi:10.1038/383525a0 · Cited by 583
Development of Structures and Transport Functions in the Mouse Placenta
Watson, E. D., & Cross, J. C. (2005) · Physiology · doi:10.1152/physiol.00001.2005 · Cited by 580
The interplay of epigenetic marks during stem cell differentiation and development
Atlasi, Y., & Stunnenberg, H. G. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.57 · Cited by 583
Testing gene function early in the B cell lineage in mb1-cre mice
Hobeika, E., Thiemann, S., Storch, B., Jumaa, H., Nielsen, P. J., Pelanda, R., & Reth, M. G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605944103 · Cited by 581
Potential mechanisms of metabolic imprinting that lead to chronic disease
Waterland, R. A., & Garza, C. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.2.179 · Cited by 565
Fan, Y., Tv, N., Zhao, J., Fleury, T. J., Bhattacharyya, R., Bouhassira, E. E., Stein, A., Woodcock, C. L. F., & Skoultchi, A. I. (2005) · Cell · doi:10.1016/j.cell.2005.10.028 · Cited by 575
The alternative role of DNA methylation in splicing regulation
Lev-Maor, G., Yearim, A., & Ast, G. (2015) · Trends in Genetics · doi:10.1016/j.tig.2015.03.002 · Cited by 604
Cooperativity between DNA Methyltransferases in the Maintenance Methylation of Repetitive Elements
Liang, G., Chan, M. F., Tomigahara, Y., Tsai, Y., Gonzales, F. A., Li, E., Laird, P. W., & Jones, P. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.480-491.2002 · Cited by 570
Self-citationDnmt3a binds deacetylases and is recruited by a sequence‐specific repressor to silence transcription
Fuks, F., Burgers, W. A., Godin, N., Kasai, M., & Kouzarides, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.10.2536 · Cited by 555
Rivera, C. M., & Ren, B. (2013) · Cell · doi:10.1016/j.cell.2013.09.011 · Cited by 550
Metadata
- Authors
- Li, E., Bestor, T. H., & Jaenisch, R.
- Affiliations
- Whitehead Institute for Biomedical Research (US)
- Harvard University (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-06
- Volume
- 69
- Issue
- 6
- Pages
- 915-926
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2046241907
- Cited by
- 3,984
- References
- 61
- Citations by year
- 2026: 50 · 2025: 60 · 2024: 81 · 2023: 84 · 2022: 84 · 2021: 90 · 2020: 95 · 2019: 127 · 2018: 137 · 2017: 113 · 2016: 147 · 2015: 157 · 2014: 169 · 2013: 178 · 2012: 187
- FWCI
- 28.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r35ca044339-13, 5r01gm043565-04)
- National Cancer Institute (R35 CA 44339-05)
- National Institute of General Medical Sciences (GM-43565)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Keywords
- DNA methyltransferases, embryonic lethality, DNA methylation, 5-methylcytosine, demethylation, embryonic stem cells, germline mutations, recessive lethality, mouse embryo development, gene targeting
- MeSH terms
- Animals, Chimera, DNA, DNA (Cytosine-5-)-Methyltransferases, Genes, Lethal, Homozygote, Methylation, Stem Cells, Blotting, Western, Mutagenesis, Insertional, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review