Cited by 444Genomics and Chromatin DynamicsChromatin Remodeling and CancerSignaling Pathways in Disease

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

Arany, Z·1994·Cell

DOI 10.1016/0092-8674(94)90127-9

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Items 201–300 of 444

The Human Proliferating Cell Nuclear Antigen Regulates Transcriptional Coactivator p300 Activity and Promotes Transcriptional Repression
Hong, R., & Chakravarti, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303138200 · Cited by 46
Transcriptional Control of Gene Expression by cAMP‐Response Element Binding Proteins
Vallejo, M. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00623.x · Cited by 46
A role for histone deacetylases in the cellular and behavioral mechanisms underlying learning and memoryPreprint
Mahgoub, M., & Monteggia, L. M. (2014) · Learning & Memory · doi:10.1101/lm.036012.114 · Cited by 45
“Due to similar structure and function, they are now often referred to as p300/CBP (Arany et al. 1994; Shiama 1997).”
Background
Histone acetylation by p300 is involved in CREB-mediated transcription on chromatin
Yuan, L. W., & Gambee, J. E. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(01)00141-0 · Cited by 45
Polydatin down-regulates the phosphorylation level of Creb and induces apoptosis in human breast cancer cell
Chen, S., Tao, J., Zhong, F., Jiao, Y., Xu, J., Shen, Q., Wang, H., Fan, S., & Zhang, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0176501 · Cited by 44
Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis
Thakur, J. K., Agarwal, P., Parida, S. K., Bajaj, D., & Pasrija, R. (2013) · Molecular Genetics and Genomics · doi:10.1007/s00438-013-0753-9 · Cited by 44
CREB takes CBP to tango
Nordheim, A. (1994) · Nature · doi:10.1038/370177a0 · Cited by 43
Selection of the best target site for ribozyme-mediated cleavage within a fusion gene for adenovirus E1A-associated 300 kDa protein (p300) and luciferase
Kawasaki, H. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.15.3010 · Cited by 42
Synergistic Activation of Human Involucrin Gene Expression by Fra-1 and p300—Evidence for the Presence of a Multiprotein Complex
Crish, J. F., & Eckert, R. L. (2007) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5701049 · Cited by 42
“An amino-acid sequence comparison of these multidomain proteins reveals numerous conserved regions, including three cysteine–histidine-rich regions (CH1, CH2, CH3), the CREB transcription factor-binding site (KIX domain), the bromodomain, the HAT domain, and the steroid receptor coactivator-1 interaction domain (Arany…”
Background
Chromatin Remodeling and Transcriptional Control in Innate Immunity: Emergence of Akirin2 as a Novel Player
Tartey, S., & Takeuchi, O. (2015) · Biomolecules · doi:10.3390/biom5031618 · Cited by 43
“modify histones [35–37].”
Expression and role of nuclear receptor coregulators in colorectal cancer
Triki, M., Lapierre, M., Cavaillès, V., & Mokdad‐Gargouri, R. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4480 · Cited by 42
Adenovirus E1A oncoprotein liberates c‐Myc activity to promote cell proliferation through abating Bin1 expression via an Rb/E2F1‐dependent mechanism
Kinney, E. L., Tanida, S., Rodrigue, A., Johnson, J., Tompkins, V. S., & Sakamuro, D. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21437 · Cited by 42
“E1A binds to and inhibits various cellular molecules, including Rb, CBP/p300, and p400, while HPV-E7 and Rb siRNA inhibit exclusively Rb.”
Background
The HTLV-1-encoded protein HBZ directly inhibits the acetyl transferase activity of p300/CBP
Wurm, T., Wright, D. G., Polakowski, N. J., Mesnard, J.-M., & Lemasson, I. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks244 · Cited by 44
“The widespread use of p300 and CBP in transcription is due to the presence of multiple, independent domains in these coactivators (2) that, together, contact more than 400 transcriptional regulators in the cell (3).”
Background
Hepatitis C Virus NS3 Protein Can Activate the Notch-Signaling Pathway through Binding to a Transcription Factor, SRCAP
Iwai, A., Takegami, T., Shiozaki, T., & Miyazaki, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020718 · Cited by 41
“formation of the complex with these factors [45,46].”
Background
African Swine Fever Virus Blocks the Host Cell Antiviral Inflammatory Response through a Direct Inhibition of PKC-θ-Mediated p300 Transactivation
Granja, A. G., Sánchez, E. G., Sabina, P., Fresno, M., & Revilla, Y. (2008) · Journal of Virology · doi:10.1128/jvi.01663-08 · Cited by 43
“In this respect, it has been demonstrated that CBP/p300 interact with multiple transcription factors, including p53 (32), E2F (42), CREB ( 3 ), NFAT (24), NF-B (25, 47), c-Jun (5), and c-Fos (4), coordinating the transcription of their target genes.”
Background
Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc
Tworkowski, K. A., Chakraborty, A. A., Samuelson, A. V., Seger, Y. R., Narita, M., Hannon, G. J., Lowe, S. W., & Tansey, W. P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802095105 · Cited by 41
Biological role of p300 in cardiac myocytes
Yanazume, T., Morimoto, T., Wada, H., Kawamura, T., & Hasegawa, K. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024132217870 · Cited by 41
“p300 and CBP are highly related nuclear proteins: human p300 and CBP proteins share 91% sequence identity [3], and have been implicated in transcriptional responses to disparate extracellular and intracellular signals.”
Recruitment of the Retinoblastoma Protein to c-Jun Enhances Transcription Activity Mediated through the AP-1 Binding Site
Nishitani, J., Nishinaka, T., Cheng, C.-H., Rong, W., Yokoyama, K. K., & Chiu, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.9.5454 · Cited by 41
Cardioprotective effect of miRNA-22 on hypoxia/reoxygenation induced cardiomyocyte injury in neonatal rats
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Acetylation and Methylation in Nuclear Receptor Gene Activation
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Discovery of Novel PROTAC Degraders of p300/CBP as Potential Therapeutics for Hepatocellular Carcinoma
Chang, Q., Li, J., Deng, Y. W., Zhou, R., Wang, B., Wang, Y., Zhang, M., Huang, X., & Li, Y. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c01468 · Cited by 41
Transcriptional Regulation of Dentin Matrix Protein 1 by JunB and p300 during Osteoblast Differentiation
Narayanan, K., Srinivas, R., Peterson, M. C., Ramachandran, A., Hao, J. J., Thimmapaya, B., Scherer, P. E., & George, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403511200 · Cited by 43
Three Conformational States of the p300 CH1 Domain Define Its Functional Properties
Dial, R., Sun, Z., & Freedman, S. J. (2003) · Biochemistry · doi:10.1021/bi034989o · Cited by 38
Negative regulation of cytokine gene transcription 1
Ye, J., & Young, H. A. (1997) · The FASEB Journal · doi:10.1096/fasebj.11.11.9285480 · Cited by 39
Cooperation between Phosphorylation and Acetylation Processes in Transcriptional Control
Espinos, E., Thaı̈, A. L. V., Pomiès, C., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.5.3474 · Cited by 39
Regulation of Liver Glucose and Lipid Metabolism by Transcriptional Factors and Coactivators
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High Levels of Oxidative Stress Globally Inhibit Gene Transcription and Histone Acetylation
Berthiaume, M., Boufaied, N., Moisan, A., & Gaudreau, L. R. (2006) · DNA and Cell Biology · doi:10.1089/dna.2006.25.124 · Cited by 38
“…reports have shown that ROS generated by different treatments can lead to histone hypoacetylation (Kang et al ., 2003, 2005; Lin et al ., 2005), and interestingly, CBP and p300 contain three cysteine–histidine (CH)-rich domains (CH1, CH2, and CH3) in their conserved regions (Arany et al ., 1994).”
Suppression of Mutations in Two Saccharomyces cerevisiae Genes by the Adenovirus E1A Protein
Zieler, H., Walberg, M. W., & Berg, P. R. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3227 · Cited by 38
“thought to be a transcriptional coactivator of CREB (2).”
Background
Transcriptional Regulation of the Mouse Ferritin H Gene
Tsuji, Y., Moran, E., Torti, S. V., & Torti, F. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.11.7501 · Cited by 37
Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington’s Disease
Paldino, E., Cardinale, A., D’Angelo, V., Sauve, I., Giampà, C., & Fusco, F. R. (2017) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2017.00061 · Cited by 37
“However, CBP is not only a transcriptional coactivator for CREB (Arany et al., 1994).”
Background
A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
Li, J., Huang, C., Xiong, T., Zhuang, C., Zhuang, C., Li, Y., Ye, J., & Gui, Y. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.32332 · Cited by 37
“The chromatin remodeling protein CREB-binding protein (CREBBP/CBP) and its paralog p300/EP300 are two highly conserved nuclear proteins originally identified for their interaction with the transcription factor CREB and with adenovirus E1a protein, respectively [6-8].”
Background
Nuclear Receptor Coregulators Are New Players in Nervous System Development and Function
Nishihara, E., O’Malley, B. W., & Xu, J. (2004) · Molecular Neurobiology · doi:10.1385/mn:30:3:307 · Cited by 37
“Molecular Neurobiology Volume 30, 2004 are homologous proteins, and both interact with a similar set of cellular factors ( 89 ,90).”
Background
A p56 Ligand Serves as a Coactivator of an Orphan Nuclear Hormone Receptor
Marcus, S. L., Winrow, C. J., Capone, J. P., & Rachubinski, R. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.44.27197 · Cited by 37
Bcl3, an IκB Protein, as a Novel Transcription Coactivator of the Retinoid X Receptor
Na, S., Choi, H., Kim, J. W., Na, D. S., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.30933 · Cited by 37
Resistance of HBL100 human breast epithelial cells to vitamin D action
Agadir, A., Lazzaro, G., Zheng, Y., Zhang, X.-K., & Mehta, R. G. (1999) · Carcinogenesis · doi:10.1093/carcin/20.4.577 · Cited by 37
Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer.
Gao, Y., Geng, J., Hong, X., Qi, J., Teng, Y., Yang, Y., Qu, D., & Chen, G. (2014) · Europe PMC (PubMed Central) · Cited by 36
Neural plasticity: changes with age
Nieto‐Sampedro, M., & Nieto-D�az, M. (2004) · Journal of Neural Transmission · doi:10.1007/s00702-004-0146-7 · Cited by 37
“Another hypothetical way in which signals from mitogens, estrogen and neurotrophins may be integrated, is through the CREB binding protein or CBP (Arany et al., 1994; Montminy, 1997).”
Background
The coactivators p300 and CBP have different functions during the differentiation of F9 cells
Ugai, H., Uchida, K., Kawasaki, H., & Yokoyama, K. K. (1999) · Journal of Molecular Medicine · doi:10.1007/s001099900021 · Cited by 37
“Greater similarity is observed in specific regions, including the regions that encompass the CREB-binding site, the E1A-binding site, and the bromodomain [ 89 ].”
Background
Effects of Depletion of CREB-binding Protein on c-Myc Regulation and Cell Cycle G1-S Transition
Rajabi, H. N., Baluchamy, S., Kolli, S., Nag, A., Srinivas, R., Raychaudhuri, P., & Thimmapaya, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408633200 · Cited by 34
Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background
Duclot, F., Jacquet, C., Gongora, C., & Maurice, T. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.077 · Cited by 35
“Nuclear FGF Receptor‐1 and CREB Binding Protein: An Integrative Signaling Module”
Stachowiak, M. K., Birkaya, B. G., Aletta, J. M., Narla, S. T., Benson, C. A., Decker, B., & Stachowiak, E. K. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24879 · Cited by 33
Fully automated high-throughput chromatin immunoprecipitation for ChIP-seq: Identifying ChIP-quality p300 monoclonal antibodies
Gasper, W. C., Marinov, G. K., Pauli, F., Scott, M. T., Newberry, K. M., DeSalvo, G., Ou, S. K.-H., Myers, R., Vielmetter, J., & Wold, B. J. (2014) · Scientific Reports · doi:10.1038/srep05152 · Cited by 34
Alterations of Gut Microbiota by Overnutrition Impact Gluconeogenic Gene Expression and Insulin Signaling
He, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042121 · Cited by 35
“P300 has an intrinsic acetyltransferase activity [44,45], and its acetyltransferase activity may affect insulin signaling.”
Background
Adenoviral E1A Function through Myc
Chakraborty, A. A., & Tansey, W. P. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-3026 · Cited by 33
“Although it can be difficult to dissect the individual contributions of each of these interactions to E1A function, a growing body of evidence indicates that interaction of E1A with chromatin remodeling proteins such as CBP/p300 ( 4 ) and p400 (5) is important for the biological activities of E1A.”
Background
p300 gene alterations in intestinal and diffuse types of gastric carcinoma
KOSHIISHI, N., Chong, J., Fukasawa, T., Ikeno, R., Hayashi, Y. K., Funata, N., Nagai, H., Miyaki, M., Matsumoto, Y., & Fukayama, M. (2004) · Gastric Cancer · doi:10.1007/s10120-004-0273-8 · Cited by 33
“On the other hand, p300 is a transcriptional coactivator that facilitates gene expression through several mechanisms [9], including molecular scaffolds coupling many transcriptional factors [10], chromatin remodeling by histone acetyltransferase (HAT) activity [11], and activation of transcription factors, such as p53…”
Background
The Adenovirus E1A Repression Domain Disrupts the Interaction between the TATA Binding Protein and the TATA Box in a Manner Reversible by TFIIB
Song, C.-Z., Loewenstein, P. M., Tóth, K., Tang, Q., Nishikawa, A., & Green, M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2186 · Cited by 33
p300 is not required for metabolic adaptation to endurance exercise training
LaBarge, S. A., Migdal, C., Buckner, E. H., Okuno, H., Gertsman, I., Stocks, B., Barshop, B. A., Nalbandian, S., Philp, A., McCurdy, C. E., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-281741 · Cited by 31
Activation of Mitogen-activated Protein Kinase p38 and Extracellular Signal-regulated Kinase Is Involved in Glass Fiber-induced Tumor Necrosis Factor-α Production in Macrophages
Ye, J., Zeidler-Erdely, P. C., Young, S., Martinez, A., Robinson, V. A., Jones, W. G., Baron, P. A., Shi, X., & Castranova, V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008814200 · Cited by 32
Macrophages Kill Human Papillomavirus Type 16 E6-Expressing Tumor Cells by Tumor Necrosis Factor Alpha- and Nitric Oxide-Dependent Mechanisms
Routes, J. M., Morris, K. R., Ellison, M. C., & Ryan, S. (2004) · Journal of Virology · doi:10.1128/jvi.79.1.116-123.2005 · Cited by 32
Analysis of genetic stability at the EP300 and CREBBP loci in a panel of cancer cell lines
Tillinghast, G. W., Partee, J., Albert, P., Kelley, J. M., Burtow, K. H., & Kelly, K. (2003) · Genes Chromosomes and Cancer · doi:10.1002/gcc.10195 · Cited by 32
“Finally, we screened the COOH-terminal portion because of the high degree of conservation between the two genes in this area (Arany et al., 1994).”
Background
CITED2 and the modulation of the hypoxic response in cancer
Fernandes, M. T., Calado, S. M., Mendes-Silva, L., & Bragança, J. (2020) · World Journal of Clinical Oncology · doi:10.5306/wjco.v11.i5.260 · Cited by 30
Adenovirus E1A Specifically Blocks SWI/SNF-Dependent Transcriptional Activation
Miller, M. E., Cairns, B. R., Levinson, R. S., Yamamoto, K. R., Engel, D. A., & Smith, M. M. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5737 · Cited by 31
“(A) Cells from exponentially growing cultures were washed twice in sterile water and resuspended in YPD medium containing 2% (1) or 0.05% ( 2 ) glucose.”
BackgroundMethodInfluential
The transcriptional activity of Pygopus is enhanced by its interaction with cAMP-response-element-binding protein (CREB)-binding protein
Andrews, P., He, Z., Popadiuk, C. M., & Kao, K. R. (2009) · Biochemical Journal · doi:10.1042/bj20090134 · Cited by 30
Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling
Singh, N. K., Kotla, S., Kumar, R., & Rao, G. N. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.09.042 · Cited by 31
“Since phosphorylation at Ser133 is required for CREB activation (Arany et al., 1994; Chrivia et al., 1993), we next examined the effect of hypoxia on CREB phosphorylation.”
Background
Regulation of the Erythropoietin Gene
Ebert, B. L., & Bunn, H. F. (1999) · Blood · doi:10.1182/blood.v94.6.1864.418k37_1864_1877 · Cited by 30
Human interleukin-5 expression is synergistically regulated by histone acetyltransferase CBP/p300 and transcription factors C/EBP, NF-AT and AP-1
LIU, C. (2004) · Cytokine · doi:10.1016/j.cyto.2004.02.003 · Cited by 30
Prefrontal consolidation supports the attainment of fear memory accuracyPreprint
Vieira, P. A., Lovelace, J. W., Corches, A., Rashid, A. J., Josselyn, S. A., & Korzus, E. (2014) · Learning & Memory · doi:10.1101/lm.036087.114 · Cited by 31
“CBP and p300 both share a very similar molecular structure (Arany et al. 1994), including intrinsic acetyltransferase activity (Ogryzko et al. 1996), and are capable to mediate similar cellular functions including CREB-dependent transcriptional activation.”
Background
Maturity-Onset Diabetes of the Young Type 1 (MODY1)-Associated Mutations R154X and E276Q in Hepatocyte Nuclear Factor 4α (HNF4α) Gene Impair Recruitment of p300, a Key Transcriptional Coactivator
Eeckhoute, J., Formstecher, P., & Laine, B. (2001) · Molecular Endocrinology · doi:10.1210/mend.15.7.0670 · Cited by 29
Binding of p300/CBP Co-activators by Polyoma Large T Antigen
Cho, S., Tian, Y., & Benjamin, T. L. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102906200 · Cited by 29
Lentivirus-mediated RNAi Targeting CREB Binding Protein Attenuates Neointimal Formation and Promotes Re-endothelialization in Balloon Injured Rat Carotid Artery
Yang, J., Jiang, H., Chen, S.-S., Chen, J., Li, W., Xu, S., & Wang, J. (2010) · Cellular Physiology and Biochemistry · doi:10.1159/000320567 · Cited by 28
Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity
Hu, J., Xu, H., Wu, T., Zhang, C., Shen, H., Dong, R., Hu, Q., Xiang, Q., Chai, S., Luo, G., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c02195 · Cited by 28
Acetylation at Lysine 183 of Progesterone Receptor by p300 Accelerates DNA Binding Kinetics and Transactivation of Direct Target Genes
Chung, H. H., Sze, S. K., Tay, A. S. L., & Lin, V. C. L. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.517896 · Cited by 28
“Since p300/CBP are closely related transcriptional co-activators with extensive sequence and structural homology (33) and overlapping functions (34), we chose from here on in to focus on p300 for its role in PR acetylation and function.”
Background
Heterogeneous Nuclear Ribonucleoprotein R Enhances Transcription from the Naturally Configured c-fos Promoter in Vitro*
Fukuda, A., Nakadai, T., Shimada, M., & Hisatake, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.013656 · Cited by 23
Deregulation of the Cell Cycle by the Epstein–Barr Virus
O’Nions, J., & Allday, M. J. (2004) · Advances in cancer research · doi:10.1016/s0065-230x(04)92006-4 · Cited by 28
The Multifunctional Role of E1A in the Transcriptional Regulation of CREB/CBP-Dependent Target Genes
Brockmann, D., & Esche, H. (2003) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-05597-7_4 · Cited by 27
The adenoviral E1A oncoproteins interfere with the growth-inhibiting effect of the cdk-inhibitor p21(CIP1/WAF1).
Keblusek, P., Dorsman, J. C., Teunisse, A. F. A. S., Teunissen, H., van der Eb, A. J., & ZANTEMA, A. (1999) · Journal of General Virology · doi:10.1099/0022-1317-80-2-381 · Cited by 25
“…and related proteins p107 (Ewen et al., 1991) and p130 (Hannon et al., 1993 ; Li et al., 1993), transcriptional coactivators p300 and CBP (CREB-binding protein) (Arany et al., 1994, 1995 ; Eckner et al., 1994 ; Lundblad et al., 1995), cyclindependent kinase cdk2 and cyclin A\E (Faha et al., 1993).”
Background
Variable Expression of the Transcription Factors cAMP Response Element-Binding Protein and Inducible cAMP Early Repressor in the Normal Adrenal Cortex and in Adrenocortical Adenomas and Carcinomas
Peri, A., Luciani, P., Conforti, B., Baglioni-Peri, S., Cioppi, F., Crescioli, C., Ferruzzi, P., Gelmini, S., Arnaldi, G., Nesi, G., et al. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.11.8042 · Cited by 26
Histone acetylation and the control of the cell cycle
Magnaghi-Jaulin, L., Ait‐Si‐Ali, S., & Harel‐Bellan, A. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4253-7_4 · Cited by 26
The N-terminal region of the adenovirus type 5 E1A proteins can repress expression of cellular genes via two distinct but overlapping domains
Dorsman, J. C., Hagmeyer, B. M., Veenstra, J. G., Elfferich, P., Nabben, N., ZANTEMA, A., & van der Eb, A. J. (1995) · Journal of Virology · doi:10.1128/jvi.69.5.2962-2967.1995 · Cited by 26
“Recent experimental and sequence comparison data suggest that p300 and CBP may function as coactivators (4, 8).”
BackgroundInfluential
Adenovirus targets transcriptional and posttranslational mechanisms to limit gap junction function
Calhoun, P. J., Phan, A. V., Taylor, J. D., James, C. C., Padget, R. L., Zeitz, M. J., & Smyth, J. W. (2020) · The FASEB Journal · doi:10.1096/fj.202000667r · Cited by 25
The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression
Wang, L., Nie, Q., Gao, M., Yang, L., Xiang, J., Xiao, Y., Liu, F.-Y., Gong, X., Fu, J., Wang, Y., et al. (2020) · Aging · doi:10.18632/aging.103474 · Cited by 25
Stimulation of DNA Replication from the Polyomavirus Origin by PCAF and GCN5 Acetyltransferases: Acetylation of Large T Antigen
Xie, A., Bermudez, V. P., & Folk, W. R. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.7907-7918.2002 · Cited by 25
Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300
Némethová, M., & Wintersberger, E. (1999) · Journal of Virology · doi:10.1128/jvi.73.2.1734-1739.1999 · Cited by 24
“This protein, p300, is a member of a group of transcriptional coactivators which includes the CREB-binding protein CBP, known to play a substantial role in the regulation of cyclicAMP-responsive genes (2, 3, 11, 21).”
Background
The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.
Dorsman, J. C., Teunisse, A. F. A. S., ZANTEMA, A., & van der Eb, A. J. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-2-423 · Cited by 26
“The CREB-binding protein CBP, together with the closely related protein p300, belong to a conserved family of transcription co-activators (Arany et al., 1994).”
Background
Involvement of GR and p300 in the Induction of H6PD by Cortisol in Human Amnion Fibroblasts
Wang, W., Guo, C., Li, W., Li, J., Wang, W., Myatt, L., & Sun, K. (2012) · Endocrinology · doi:10.1210/en.2012-1531 · Cited by 25
Prognostic Significance of CREB-Binding Protein and CD81 Expression in Primary High Grade Non-Muscle Invasive Bladder Cancer: Identification of Novel Biomarkers for Bladder Cancer Using Antibody Microarray
Lee, M., Kim, J. H., Lee, J.-S., Yun, S. J., Kim, W., Ahn, H., & Park, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125405 · Cited by 25
“CREBBP is highly homologous and functionally related to p300, which was originally identified as a protein that interacts with the adenoviral E1A oncoprotein [34, 35].”
Background
Peroxisome proliferator-activated receptor α activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines
Oshio, H., Abe, T., Onogawa, T., Ohtsuka, H., Sato, T., Ii, T., Fukase, K., Muto, M., Katayose, Y., Oikawa, M., et al. (2008) · Journal of Gastroenterology · doi:10.1007/s00535-008-2188-3 · Cited by 24
Susceptibility to Cell Death Induced by Mutant SV40 T-Antigen Correlates with Purkinje Neuron Functional Development
Feddersen, R. M., Yunis, W. S., O'Donnell, M. A., Ebner, T. J., Shen, L., Iadecola, C., Orr, H. T., & Clark, H. B. (1997) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1997.0601 · Cited by 24
Transcriptional Repression by Human Adenovirus E1A N Terminus/Conserved Domain 1 Polypeptides in Vivo and in Vitro in the Absence of Protein Synthesis
Song, C.-Z., Tierney, C. J., Loewenstein, P. M., Pusztai, R., Symington, J. S., Tang, Q., Tóth, K., Nishikawa, A., Bayley, S. T., & Green, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.40.23263 · Cited by 23
Loci-specific histone acetylation profiles associated with transcriptional coactivator p300 during early myoblast differentiation
Khilji, S., Hamed, M., Chen, J., & Li, Q. (2018) · Epigenetics · doi:10.1080/15592294.2018.1489659 · Cited by 23
TAZ2 truncation confers overactivation of p300 and cellular vulnerability to HDAC inhibition
Xu, L., Xuan, H., He, W., Zhang, L. N., Huang, M., Li, K., Wen, H., Xu, H., & Shi, X. (2023) · Nature Communications · doi:10.1038/s41467-023-41245-2 · Cited by 23
Coactivator CBP in the regulation of conceptus IFNτ gene transcription
Xu, N., Takahashi, Y., Matsuda, F., Sakai, S., Christenson, R. K., & Imakawa, K. (2003) · Molecular Reproduction and Development · doi:10.1002/mrd.10293 · Cited by 22
“In addition, another coactivator, p300, is generally thought to participate in the same or similar biological processes as CBP as they share about 85% homology in their functional domains (Arany et al., 1994).”
Background
Nuclear receptor/Wnt beta-catenin interactions are regulated via differential CBP/p300 coactivator usage
Ono, M., Lai, K. K. Y., Wu, K., Nguyen, C., Lin, D. P., Murali, R., & Kahn, M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200714 · Cited by 22
Identification and functional characterization of a novel mutation of hepatocyte nuclear factor-1α gene in a Korean family with MODY3
Kim, K.-A., Kang, K., Chi, Y., Chang, I., Lee, M.-K., Kim, K.-W., Shoelson, S. E., & Lee, M. (2003) · Diabetologia · doi:10.1007/s00125-003-1079-7 · Cited by 22
“In some experiments, HNF-1β or global transcriptional coactivator p300 [14, 15] were transfected together with WT HNF-1α or its mutant.”
Method
A Genetic Screen Identifies Putative Targets and Binding Partners of CREB-Binding Protein in the Developing Drosophila Eye
Anderson, J. G., Bhandari, R., & Kumar, J. P. (2005) · Genetics · doi:10.1534/genetics.105.045450 · Cited by 23
“…of the basal transcriptional machinery, sequence-specific DNA-binding proteins, nuclear hormone receptors, and terminal members of several signaling transduction cascades (Arany et al. 1994; Kwok et al. 1994; Kee et al. 1996; Gu et al. 1997; Chan and La Thangue 2001; McManus and Hendzel 2001).”
Background
Distinct domains of adenovirus E1A interact with specific cellular factors to differentially modulate human immunodeficiency virus transcription
Parker, S. F., Felzien, L. K., Perkins, N. D., Imperiale, M. J., & Nabel, G. J. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.2004-2012.1997 · Cited by 22
“In analogous studies, the ability of E1A to repress Ap1 activity has been shown to result from the sequestration of the coactivator CBP from c-Fos (4).”
BackgroundInfluential
Identification of extractable growth factors from small intestinal submucosa
Voytik‐Harbin, S. L., Brightman, A. O., Kraine, M. R., Waisner, B. Z., & Badylak, S. F. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19971215)67:4 · Cited by 608
Group 3 medulloblastoma transcriptional networks collapse under domain specific EP300/CBP inhibition
Shendy, N. A. M., Bikowitz, M. J., Sigua, L. H., Zhang, Y., Mercier, A. L., Khashana, Y., Nance, S., Liu, Q., Delahunty, I. M., Robinson, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47102-0 · Cited by 21
“acetyltransferases (HATs), EP300 and CBP 4 – 7 .”
Influential
Evolutionary conservation and murine embryonic expression of the gene encoding the SERTA domain-containing protein CDCA4 (HEPP)
Bennetts, J. S., Fowles, L., Berkman, J. L., van Bueren, K. L., Richman, J. M., Simpson, F., & Wicking, C. (2006) · Gene · doi:10.1016/j.gene.2006.01.027 · Cited by 21
Mammary tumors induced by human adenovirus type 9: A role for the viral early region 4 gene
Javier, R. T., & Shenk, T. E. (1996) · Breast Cancer Research and Treatment · doi:10.1007/bf01806078 · Cited by 21
“cdk2 [15], and p300, a protein related to the CREB binding protein CBP [ 16 ].”
Background
Transcriptional Up-regulation of the Delayed Early GeneHRS/SRp40during Liver Regeneration
Du, K., Leu, J. I.-J., Peng, Y., & Taub, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35208 · Cited by 21
Immortalization of T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Is Independent of the Tax-CBP/p300 Interaction
Robek, M. D., & Ratner, L. (2000) · Journal of Virology · doi:10.1128/jvi.74.24.11988-11992.2000 · Cited by 20
The cloning, mapping and expression of a novel gene, BRL, related to the AF10 leukaemia gene
McCullagh, P. J., Chaplin, T., Meerabux, J., Grenzelias, D., Lillington, D. M., Poulsom, R., Gregorini, A., Saha, V., & Young, B. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203117 · Cited by 21
“…including yeast and human GCN5 (Brownell et al., 1996; Candau et al., 1996; Georgakopoulos and Thireos, 1992; Wang et al., 1997), p300/CBP (Arany et al., 1994; Arias et al., 1994; Bannister and Kouzarides, 1996; Chrivia et al., 1993; Kwok et al., 1994; Ogryzko et al., 1996), pCAF (Yang et…”
Regulation of the Human Proliferating Cell Nuclear Antigen Promoter by the Adenovirus E1A-Associated Protein p107
Lee, B. H., Liu, M., & Mathews, M. B. (1998) · Journal of Virology · doi:10.1128/jvi.72.2.1138-1145.1998 · Cited by 21
“by on January 26, 2010 jvi.asm.org Downloaded from blastoma susceptibility gene product, pRB; pRB-related proteins p107 and p130; and the transcriptional coactivators p300 and CBP (the CREB-binding protein) ( 2 , 3, 5, 19, 20, 41, 43).”
Background
CBP knockdown inhibits angiotensin II-induced vascular smooth muscle cells proliferation through downregulating NF-kB transcriptional activity
Yang, J., Jiang, H., Chen, S.-S., Chen, J., Xu, S., Li, W., & Wang, J. (2010) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-010-0400-2 · Cited by 20
“CREB binding protein (CBP) belongs to a highly conserved family of multifunctional proteins, which plays a fundamental role in cellular processes [ 16 , 17].”
Background
Epigenetically downregulated Semaphorin 3E contributes to gastric cancer
Chen, H., Xie, G.-H., Wang, W., Yuan, X.-L., Xing, W.-M., Liu, H.-J., Chen, J., Dou, M., & Shen, L.-S. (2015) · Oncotarget · doi:10.18632/oncotarget.3936 · Cited by 20
“The homologous nuclear proteins p300 and CBP are transcriptional co-activators that they can couple with various transcription factors to act as a protein scaffold in order to facilitate gene expression [34].”
Nucleosome Assembly and Remodeling
Ito, T. (2003) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-55747-7_1 · Cited by 20
Multiple Layers of Control in Transcriptional Regulation by MCAT Elements and the TEF-1 Protein Family
Larkin, S. B., & Ordahl, C. P. (1999) · Elsevier eBooks · doi:10.1016/b978-012329860-7/50020-9 · Cited by 20
The subunit-exchange model of histone acetylation
Dent, S., & Allis, C. D. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)20032-7 · Cited by 20
Taking the road less traveled – the therapeutic potential of CBP/β-catenin antagonists
Kahn, M. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1992386 · Cited by 19
“p300 retain an extremely high degree of identity, up to 93%, particularly over a large central core that includes the CH1, KIX, Bromodomain, and CH2 and CH3 regions (Figure 2) [54,55].”
Background

Authors: Arany, Z.
Affiliations: Harvard University (US)
Corresponding author: Arany, Z
ORCID: Arany, Z
Venue: Cell
Publisher: Elsevier BV
Published: 1994-06-17
Volume: 77
Issue: 6
Pages: 799-800
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90127-9
OpenAlex: W2087880580
Cited by: 444
References: 10
Citations by year: 2026: 8 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 7
FWCI: 13.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: P300, CREB-binding protein, CBP, transcriptional coactivator, CREB
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Trans-Activators, Conserved Sequence, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Adenovirus E1A Proteins, E1A-Associated p300 Protein, CREB-Binding Protein

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

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