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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

Arany, Z·1994·Cell

DOI 10.1016/0092-8674(94)90127-9

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p300/CBP proteins: HATs for transcriptional bridges and scaffolds
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“1 b and Table 2 ), a region which is highly conserved in its homologue CREB-binding protein (CBP; ref”
Background
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BackgroundInfluential
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CBP‐induced stimulation of c‐Fos activity is abrogated by E1A.
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“p300 and CBP are highly similar proteins with acetyltransferase activity that show approximately 91% homology in their histone acetyltransferase (HAT) domains [56–60].”
Background
The regulation of AP-1 activity by mitogen-activated protein kinases
Karin, M., & Marshall, C. J. (1996) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1996.0008 · Cited by 334
Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.
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Rubinstein–Taybi syndrome
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Regulation of the Erythropoietin Gene
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Genetic Dissection of Cardiac Growth Control Pathways
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p300 is required for MyoD‐dependent cell cycle arrest and muscle‐specific gene transcription
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“Immunoprecipitation and indirect immunofluorescence with anti-p300 antibodies were also per-tially involved in additional protein–protein interactions (Rikitake and Moran, 1992; Arany et al., 1994, 1995; formed using C2C12 cells at different times during differentiation.”
Background
Forkhead Box M1B Transcriptional Activity Requires Binding of Cdk-Cyclin Complexes for Phosphorylation-Dependent Recruitment of p300/CBP Coactivators
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Large-scale discovery of enhancers from human heart tissue
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“We performed chromatin immunoprecipitation with a pan-specific antibody that recognizes both p300 and the closely related CBP coactivator protei”
Method
Transcriptional regulation by steroid hormones
Beato, M., Chávez, S., & Truss, M. (1996) · Steroids · doi:10.1016/0039-128x(96)00030-x · Cited by 262
Hijacking of the AP-1 Signaling Pathway during Development of ATL
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“Although E1A induces c-jun transcription (Van Dam et al., 1993), it concomitantly represses AP-1 activity through competition for CREB-binding protein (CBP) in a similar manner to the competitive effect of E1A binding on p300 (Offringa et al., 1990; Arany et al., 1994).”
Background
Triggering the Interferon Response: The Role of IRF-3 Transcription Factor
Hiscott, J. B., Pitha, P. M., Génin, P., Nguyen, H., Heylbroeck, C., Mamane, Y., Algarté-Génin, M., & Lin, R. (1999) · Journal of Interferon & Cytokine Research · doi:10.1089/107999099314360 · Cited by 244
Association of p300 and CBP with Simian Virus 40 Large T Antigen
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“p300 displays striking homology (2) to another large nuclear protein, CBP, which was cloned as part of a search for proteins capable of binding to the transcription factor CREB after its phosphorylation by protein kinase A (9, 35).”
BackgroundMethodInfluentialSelf-citation
Steroid Receptor Coactivator-1 Interacts with the p50 Subunit and Coactivates Nuclear Factor κB-mediated Transactivations
Na, S.-Y., Lee, S., Han, S., Choi, H., Im, S., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.18.10831 · Cited by 235
Coactivators in PPAR-Regulated Gene Expression
Viswakarma, N., Jia, Y., Bai, L., Vluggens, A., Borensztajn, J., Xu, J., & Reddy, J. K. (2010) · PPAR Research · doi:10.1155/2010/250126 · Cited by 241
“These proteins are well conserved amongst mammals and homologs of CBP/p300 have been found in Drosophila, Caenorhabditis elegans, and Arabidopsis thaliana [105].”
Background
Transcriptional regulation by cyclic AMP-responsive factors
Cesare, D. D., & Sassone‐Corsi, P. (2000) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(00)64009-6 · Cited by 237
Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-β involves functional cooperation with p300/CBP transcriptional coactivators
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“…function as transcriptional coactivators or adapter proteins that are recruited to target promoters by sequence-speci®c DNA-binding proteins. p300/CBP interact with CREB, jun, MyoD, the STATs, p53, nuclear hormone receptors and other transcriptional factors (Giles et al., 1998: Arany et al., 1994).”
Background
Relationship between alkaline phosphatase levels, osteopontin expression, and mineralization in differentiating MC3T3-E1 osteoblasts
Beck, G. R., Sullivan, E. C., Morán, E., & Zerler, B. R. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(19980201)68:2 · Cited by 224
Characterization of the Transcriptional Regulator YY1
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A Nuclear Factor, ASC-2, as a Cancer-amplified Transcriptional Coactivator Essential for Ligand-dependent Transactivation by Nuclear Receptors in Vivo
Lee, S., Anzick, S. L., Choi, J. E., Bubendorf, L., Guan, X., Jung, Y., Kallioniemi, O., Kononen, J., Trent, J. M., Azorsa, D. O., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.48.34283 · Cited by 216
A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions
Yang, C., Shapiro, L. H., Rivera, M., Kumar, A., & Brindle, P. K. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2218 · Cited by 212
“The receptor interaction domain (RID), the three cysteine-plus histidine-rich domains (CH1, CH2, and CH3), the CREB binding KIX domain (KIX), and the bromodomain (Br) are shown (6, 19, 22, 36, 58).”
Background
Differential Use of CREB Binding Protein-Coactivator Complexes
Kurokawa, R., Kalafus, D., Ogliastro, M.-H., Kioussi, C., Xu, L., Torchia, J., Rosenfeld, M. G., & Glass, C. K. (1998) · Science · doi:10.1126/science.279.5351.700 · Cited by 211
Interaction of the co‐activator CBP with Myb proteins: effects on Myb‐specific transactivation and on the cooperativity with NF‐M.
Oelgeschläger, M., Janknecht, R., Krieg, J., Schreek, S., & Lüscher, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00637.x · Cited by 211
Mechanism of Suppression of Cytochrome P-450 1A1 Expression by Tumor Necrosis Factor-α and Lipopolysaccharide*
Ke, S., Rabson, A., Germino, J., Gallo, M., & Tian, Y.-N. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106286200 · Cited by 217
Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits
Lee, S., Kim, H.-J., Na, S., Kim, T. S., Choi, H., Im, S., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16651 · Cited by 206
Lineage-specific Signaling in Melanocytes
Price, E. R., Ding, H., Badalian, T. M., Bhattacharya, S., Takemoto, C. M., Yao, T., Hemesath, T. J., & Fisher, D. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.17983 · Cited by 202
Identification of Human Proteins Functionally Conserved with the Yeast Putative Adaptors ADA2 and GCN5
Candau, R., Moore, P. A., Wang, L., Barlev, N. A., Ying, C. Y., Rosen, C. A., & Berger, S. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.2.593 · Cited by 191
Modulation of Smooth Muscle Gene Expression by Association of Histone Acetyltransferases and Deacetylases with Myocardin
Cao, D., Wang, Z., Zhang, C., Oh, J., Xing, W., Li, S., Richardson, J. A., Wang, D.-Z., & Olson, E. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.25.1.364-376.2005 · Cited by 185
Xenopus NF‐Y pre‐sets chromatin to potentiate p300 and acetylation‐responsive transcription from the Xenopus hsp70 promoter in vivo
Li, Q., Herrler, M., Landsberger, N., Kaludov, N. K., Ogryzko, V. V., Nakatani, Y., & Wolffe, A. P. (1998) · The EMBO Journal · doi:10.1093/emboj/17.21.6300 · Cited by 183
“…the inhibition by the viral oncoprotein E1A of transcriptional activation mediated by a variety of DNA-bound transcription factors (Eckner et al., 1994, 1996a,b; Arany et al., 1994; Lundblad et al., 1995; Chakravati et al., 1996; Gerritsen et al., 1997; Aarnisalo et al., 1998; Blobel et al., 1998).”
Background
Characterization of Physical Interactions of the Putative Transcriptional Adaptor, ADA2, with Acidic Activation Domains and TATA-binding Protein
Barlev, N. A., Candau, R., Wang, L., Darpino, P., Silverman, N. S., & Berger, S. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19337 · Cited by 184
MOZ is fused top300 in an acute monocytic leukemia with t(8;22)
Chaffanet, M., Gressin, L., Preudhomme, C., Soenen, V., Birnbaum, D., & P�busque, M.-J. (2000) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(200006)28:2 · Cited by 184
The Role of Bromodomain Proteins in Regulating Gene Expression
Josling, G. A., Selvarajah, S. A., Petter, M., & Duffy, M. F. (2012) · Genes · doi:10.3390/genes3020320 · Cited by 189
“CBP and p300 belong to the same class of HATs and are very similar in structure [107].”
Background
Coupling cAMP Signaling to Transcription in the Liver: Pivotal Role of CREB and CREM
Servillo, G., Fazia, M. A. D., & Sassone‐Corsi, P. (2002) · Experimental Cell Research · doi:10.1006/excr.2002.5491 · Cited by 175
p300 Functions as a Coactivator for the Peroxisome Proliferator-activated Receptor α
Dowell, P., Ishmael, J. E., Avram, D., Peterson, V. J., Nevrivy, D. J., & Leid, M. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.33435 · Cited by 180
EP300 Selectively Controls the Enhancer Landscape of MYCN -Amplified Neuroblastoma
Durbin, A. D., Wang, T., Wimalasena, V. K., Zimmerman, M. W., Li, D., Dharia, N. V., Mariani, L., Shendy, N. A. M., Nance, S., Patel, A. G., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0385 · Cited by 181
“These two enzymes share a 95 large degree of sequence homology, and both contain multiple homologous domains, including 96 kinase-inducible domain interacting (KIX) domains, histone acetyltransferases (HAT) and 97 bromodomains (14).”
Background
An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300
Harrod, R., Tang, Y., Nicot, C., Lu, H. S., Vassilev, A. P., Nakatani, Y., & Giam, C. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.9.5052 · Cited by 177
CREB phosphorylation at Ser133 regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling
Naqvi, S., Martin, K. J., & Arthur, J. S. C. (2014) · Biochemical Journal · doi:10.1042/bj20131115 · Cited by 187
CREB-binding Protein Activates Transcription through Multiple Domains
Swope, D. L., Mueller, C. L., & Chrivia, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.45.28138 · Cited by 169
A CBP/p300 homolog specifies multiple differentiation pathways in Caenorhabditis elegansPreprint
Shi, Y., & Mello, C. C. (1998) · Genes & Development · doi:10.1101/gad.12.7.943 · Cited by 170
“CBP-1 is a C. elegans protein that shares significant sequence homology with mammalian p300 and CBP proteins (Chrivia et al. 1993; Arany et al. 1994; Eckner et al. 3Corresponding author.”
Background
Genetic syndromes caused by mutations in epigenetic genes
Berdasco, M., & Esteller, M. (2013) · Human Genetics · doi:10.1007/s00439-013-1271-x · Cited by 176
CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
Shi, D., Pop, M. S., Kulikov, R., Love, I. M., Kung, A. L., & Grossman, S. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904305106 · Cited by 165
“The N terminus of p300 harbors its E3/E4 activity (14), and the same region of CBP encodes its E3/E4 activity and shares significant areas of sequence conservation (18, 30).”
Background
Yeast RSP5 and Its Human Homolog hRPF1 Potentiate Hormone-Dependent Activation of Transcription by Human Progesterone and Glucocorticoid Receptors
Imhof, M. O., & McDonnell, D. P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2594 · Cited by 159
Expression of HDAC1 and CBP/p300 in human colorectal carcinomas
Ishihama, K., Yamakawa, M., Semba, S., Takeda, H., Kawata, S., Kimura, S., & Kimura, W. (2007) · Journal of Clinical Pathology · doi:10.1136/jcp.2005.029165 · Cited by 157
Adenovirus E1A Downregulates cJun- and JunB-Mediated Transcription by Targeting Their Coactivator p300
Lee, J.-S., See, R. H., Deng, T., & Shi, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4312 · Cited by 153
“p300 shares significant homology with the transcriptional cofactor CBP (4).”
Background
Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation
Billon, N., Carlisi, D., Datto, M., van Grunsven, L. A., Watt, A. J., Wang, X., & Rudkin, B. B. (1999) · Oncogene · doi:10.1038/sj.onc.1202712 · Cited by 150
“Indeed, p300/ CBP have been shown to interact functionally with a number of transcriptional activators including CREB (Chrivia et al., 1993; Arany et al., 1994; Kwok et al., 1994), bHLH factors (Eckner et al., 1996; Puri et al., 1997), pp90RSK (Nakajima et al., 1996; Xing et al., 1996), nuclear…”
Background
p300 Modulates the BRCA1 inhibition of estrogen receptor activity.
Fan, S., Ma, Y. X., Wang, C., Yuan, R., Meng, Q., Wang, J., Erdos, M. R., Goldberg, I. D., Webb, P., Kushner, P. J., et al. (2002) · PubMed · Cited by 148
Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator
Ko, L., Cardona, G. R., & Chin, W. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.11.6212 · Cited by 144
Identification of ARA70 as a Ligand-enhanced Coactivator for the Peroxisome Proliferator-activated Receptor γ
Heinlein, C. A., Ting, H., Yeh, S., & Chang, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16147 · Cited by 135
Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression
Li, P., Black, T. A., Shi, Q., Jones, C. A., Petrovic, N., Loudon, J. A., Kane, C. M., Sigmund, C. D., & Gross, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103010200 · Cited by 133
Molecular Mechanisms of Transforming Growth Factor- Signaling
Hu, P. P.-C., Datto, M., & Wang, X. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0333 · Cited by 137
KATs in cancer: functions and therapies
Farria, A. T., Li, W., & Dent, S. (2015) · Oncogene · doi:10.1038/onc.2014.453 · Cited by 134

Authors: Arany, Z.
Affiliations: Harvard University (US)
Corresponding author: Arany, Z
ORCID: Arany, Z
Venue: Cell
Publisher: Elsevier BV
Published: 1994-06-17
Volume: 77
Issue: 6
Pages: 799-800
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90127-9
OpenAlex: W2087880580
Cited by: 444
References: 10
Citations by year: 2026: 8 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 7
FWCI: 13.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: P300, CREB-binding protein, CBP, transcriptional coactivator, CREB
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Trans-Activators, Conserved Sequence, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Adenovirus E1A Proteins, E1A-Associated p300 Protein, CREB-Binding Protein

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

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