Cited by 444Genomics and Chromatin DynamicsChromatin Remodeling and CancerSignaling Pathways in Disease

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

Arany, Z·1994·Cell

DOI 10.1016/0092-8674(94)90127-9

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BackgroundMethod
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The retinoblastoma gene family members pRB and p107 coactivate the AP-1-dependent mouse tissue factor promoter in fibroblasts
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“…protein (CBP) and the closely related coactivator p300 (collectively referred to as CBP/p300) have been shown to cooperate with a variety of transcriptional activating proteins to regulate speci®c gene transcription (Kwok et al., 1994; Lundblad et al., 1995; Arany et al., 1994; Arias et al., 1994).”
Background
c-myc-dependent hepatoma cell apoptosis results from oxidative stress and not a deficiency of growth factors
Xu, Y., Nguyen, Q., Lo, D. C., & Czaja, M. J. (1997) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199702)170:2 · Cited by 70
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“…coupled receptors induce accumulation of cAMP, which activates PKA to phosphorylate CREB at S133 (Hagiwara et al., 1993) and promotes recruitment of the transcription co- activator CBP and its paralogue p300 (Arany et al., 1994; Chrivia et al., 1993; Del et al., 2019; Ebrahimi et al., 2019).”
BackgroundResult
p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair
Lai, K. K. Y., Hu, X., Chosa, K., Nguyen, C., Lin, D. P., Lai, K., Kato, N., Higuchi, Y., Highlander, S. K., Melendez, E., et al. (2021) · Cancers · doi:10.3390/cancers13061288 · Cited by 17
“CBP and p300 have maintained an extraordinarily high degree of identity—as high as 93%—and an even higher degree of similarity, particularly over an extensive central core region, which encompasses the CH1, KIX, bromodomain, CH2 and CH3 domains (Figure 1A) [1,2,4,5].”
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Role of p300-family proteins in E1A oncogene induction of cytolytic susceptibility and tumor cell rejection
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“A high degree of homology is shared between CBP and p300 that are usually referred to as CBP/p300 [108].”
BackgroundInfluential
CBP/p300: intramolecular and intermolecular regulations
Xue, Y., Wen, H., & Shi, X. (2018) · Frontiers in Biology · doi:10.1007/s11515-018-1502-6 · Cited by 18
“…is complex but strictly controlled, involving a network of numerous regulatory factors, such as cAMP response element binding protein (CREB) binding protein (CREBBP, aka CBP or lysine acetyltransferase 3A, KAT3A) and its close paralogue p300 (aka KAT3B) (Arany et al., 1994; Vo and Goodman, 2001).”
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“Previous observations indicate that gene repression is determined by binding of CR1 and CR2 to cellular coactivator proteins of the p300/CBP protein family (3, 4, 29).”
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“1993) and which is closely related to the E1A associated protein P300 (Arany et al. 1994).”
Background
c-Jun Enhancement of Cyclic Adenosine 3',5'-Monophosphate Response Element-Dependent Transcription Induced by Transforming Growth Factor- Is Independent of c-Jun Binding to DNA
Hu, P. P.-C., Harvat, B. L., Hook, S. S., Shen, X., Wang, X., & Means, A. R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0405 · Cited by 13
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“CBP and p300 are paralogous proteins containing multiple protein interaction domains [5, 6], among which the KIX domain shares 90% homology [5] and has been reported to interact with b-catenin [7].”
Background
The prognostic capacities of CBP and p300 in locally advanced rectal cancer
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Evidence for the Role of Cyclic AMP-Responsive Elements in Human Virus Replication and Disease.
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Trout GH promoter analysis reveals a modular pattern of regulation consistent with the diversification of GH gene control and function in vertebrates
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Germline or inducible knockout of p300 or CBP in skeletal muscle does not alter insulin sensitivity
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“p300 and CBP share 61% sequence homology across the entire protein and ~80–90% sequence homology in the acetyltransferase domain (2, 12) and as such, are widely considered to be functional homologues (10, 12, 72).”
Background
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“They retain an extremely high degree of identity, up to 93%, particularly over a large central core that includes the CH1, KIX, Bromodomain and CH2 and CH3 regions (Figure S1A) [20,21].”
Background
Role of CREB Protein Family Members in Human Haematological Malignancies
DAuria, F., & Di, R. (2013) · InTech eBooks · doi:10.5772/55368 · Cited by 9
Isolation of CHO-K1 clones defective in cAMP-dependent proteolysis, as determined by the stability of exogenously expressed GATA-6
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An overview of nuclear receptor coregulators involved in cerebellar development
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“CBP and p300 interact with a similar set of NRs, including ER, TR, GR, RAR, and RXR ( 71 ) and contain several conserved regions such as the NR interaction domain with the LXXLL motif in the N-terminus, the CREB interaction domain (KIX), three zinc finger regions (CH1, CH2, and CH3) to which various transcription fact…”
Background
Mass-spectrometric analysis of agonist-induced retinoic acid receptor γ conformational change
Peterson, V. J., Barofsky, E., Deinzer, M. L., Dawson, M. I., Feng, K.-C., Zhang, X.-K., Madduru, M. R., & Leid, M. E. (2002) · Biochemical Journal · doi:10.1042/0264-6021:3620173 · Cited by 9
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Liu, C., Pan, Y., Wang, X., Lu, J., Huang, B., & Li, X. (2010) · Cell Biology International · doi:10.1042/cbi20090388 · Cited by 8
“Both p300 and CBP are transcriptional coactivators that facilitate gene expression through coupling many transcription factors as molecular scaffolds (Arany et al., 1994).”
Background
Transcriptional regulation of peripheral glial cell differentiation in the embryonic nervous system of drosophila
Schmidt, I., Franzdóttir, S. R., Edenfeld, G., Rodrigues, F., Zierau, A., & Klämbt, C. (2011) · Glia · doi:10.1002/glia.21123 · Cited by 9
“…proteins (CBP), which act as transcriptional co-activators for a multitude of transcription factors that can influence the transcriptional machinery in many ways (Akimaru et al., 1997a,b; Arany et al., 1994; Chrivia et al., 1993; Das et al., 2009; Janknecht and Hunter, 1996; Ogryzko et al., 1996).”
Background
Identification of Genes Regulating Gene Targeting by a High-Throughput Screening Approach
Delacôte, F., Perez, C., Guyot, V., Mikonio, C., Potrel, P., Cabaniols, J., Delenda, C., Pâques, F., & Duchateau, P. N. (2011) · Journal of Nucleic Acids · doi:10.4061/2011/947212 · Cited by 8
“ATF7IP is involved in histone methylation, another type of transcription-related epigenetic modification [56, 64]: it is required to stimulate the histone methyltransferase activity of SETDB1 [57].”
Background
The Inhibitory Effect of Testosterone on PPARγ-induced Adipogenesis
Jeong, S. (2016) · The Korean Journal of Obesity · doi:10.7570/kjo.2016.25.2.68 · Cited by 7
“이러한 수용체들 의 전사작용의 활성은 transcriptional coactivators에 의해 증가되며 이러한 작용은 리간드의 존재에 의존적이다.(38,39) 최근 연구결과에 의 하면 AR의 대표적인 coactivators인 ARA70은 AR뿐만 아니라 PPARγ 의 coactivators로서 작용한다고 보고되고 있고, dihydro테스토스테 론에 의해 활성화된 AR이 PPARγ-ARA70 transactivation을 방해함 으로써 지방세포에서 PPARγ-mediated response와 AR-mediated response 간에 negative signalin…”
Intracellular Factors Involved in Gene Expression of Human Retroviruses
Ou, S.-H. I., & Gaynor, R. B. (1995) · Springer eBooks · doi:10.1007/978-1-4899-1721-8_2 · Cited by 7
Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor
Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S., & Langelaan, D. N. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119520 · Cited by 6
The winged helix domain of MORF binds CpG islands and the TAZ2 domain of p300
Becht, D. C., Kanai, A., Biswas, S., Halawa, M., Zeng, L., Cox, K. L., Poirier, M. G., Zhou, M., Shi, X., Yokoyama, A., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109367 · Cited by 6
“19–21 p300/CBP promote gene expression through acetylating histone H3K18 and H3K27 but can also acetylate non-histone proteins.”
Background
Expression of cAMP Response Element Binding Protein (CREB)‐Binding Protein (CBP) and the Implication in Retinoic Acid‐Inducible Transcription Activation in Human Salivary Gland Adenocarcinoma Cell Line HSG
Kyakumoto, S., 鬼頭, 典., & Sato, N. (2003) · Endocrine Research · doi:10.1081/erc-120025035 · Cited by 6
Expression of p300-truncated fragments results in the modulation of apoptosis in rat mesangial cells
Segelmark, M., Barrett, C. V., Pendergraft, W., Falk, R. J., & Preston, G. A. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00037.x · Cited by 5
Accumulation of p300 mediates transcriptional repression of simian virus 40 enhancer in undifferentiated F9 embryonal carcinoma cells.
Ota, M. S., Eto, K., Ninomiya, Y., & Ikeda, M. (1998) · PubMed · Cited by 6
PRRX1-rearranged Fibroblastic Tumors
Dehner, C. A., Torres‐Mora, J., Thangaiah, J. J., Oliveira, A. M., Michal, M., Malik, F., Din, N. U., Hassan, U., Maqbool, H., Obeidin, F., et al. (2025) · The American Journal of Surgical Pathology · doi:10.1097/pas.0000000000002472 · Cited by 5
Transcription Factors
Newton, R. C., Barnes, P. J., & Adcock, I. M. (1998) · Elsevier eBooks · doi:10.1016/b978-012079027-2/50107-6 · Cited by 5
Minireview
(1996) · Biological Chemistry Hoppe-Seyler · doi:10.1515/bchm3.1996.377.11.685 · Cited by 5
Transcription and the Control of Gene Expression
Wiper‐Bergeron, N., & Skerjanc, I. S. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-440-7_2 · Cited by 3
Interactions between XIAP Associated Factor 1 and a Nuclear Co-Activator, CBP, in Colon Cancer Cells
Sun, Y., Qiao, L., Zou, B., Xia, H. H., Gu, Q., Ma, J., Lin, M. C. M., Zhu, Q., Zhu, S., Dai, Y., et al. (2008) · Digestion · doi:10.1159/000121441 · Cited by 4
Mutations in CREBBP and EP300 HAT and Bromo Domains Drive Hypermutation and Predict Survival in GI Cancers Treated with Immunotherapy
Gusakova, M., Сергеевич, Ш. Ф., Мамчур, А. А., Boulygina, E., Mochalova, A. S., Владимирович, Б. А., & Patrushev, M. V. (2025) · Biomedicines · doi:10.3390/biomedicines13112592 · Cited by 3
Comparative crystal structure analysis of the human EP300 and CBP KIX domains
Cho, S. E., Lee, Y., Kim, J., Jung, K.-Y., Jeong, H., Park, H. W., & Lee, B. I. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.151064 · Cited by 3
HATs and HDACs
Bolger, T. A., Cohen, T., & Yao, T. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_6 · Cited by 4
Discovery of 5-imidazole-3-methylbenz[d]isoxazole derivatives as potent and selective CBP/p300 bromodomain inhibitors for the treatment of acute myeloid leukemia
Hu, J., Tang, X., Luo, G., Zhang, C., Wu, T., Wang, C., Shen, H., Zhao, X., Wu, X., Smaill, J. B., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01478-x · Cited by 2
Safely Targeting Cancer, the Wound That Never Heals, Utilizing CBP/Beta-Catenin Antagonists
Higuchi, Y., Teo, J.-L., Yi, D., & Kahn, M. (2025) · Cancers · doi:10.3390/cancers17091503 · Cited by 3
“Despite diverging over 450 million years ago, they retain an extremely high degree of identity, up to 93%, particularly over a large central core that includes the CH1, KIX, Bromodomain, and CH2 and CH3 regions (Figure 2) [155,156].”
Multiple transactivation domains of EZH2 bind to the TAZ2 domain of p300 and stimulate the acetyltransferase function of p300
Becht, D. C., Biswas, S., Xu, C., Xuan, H., Khalil, M., Cai, L., Musselman, C. A., Liu, X., Affar, E. B., Shi, X., et al. (2025) · Biochemical Journal · doi:10.1042/bcj20253037 · Cited by 2
Role of Alteration/Deficiency in Activation (ADA) Complex in Cell Cycle, Genomic Instability and Cancer
Mohibi, S., Srivastava, S., Band, H., & Band, V. (2013) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-4614-8039-6_2 · Cited by 2
Neural Plasticity and Central Nervous System Lesion Repair
Nieto‐Sampedro, M. (2004) · Springer eBooks · doi:10.1007/1-4020-2541-6_21 · Cited by 2
“Another way in which signals from mitogens, estrogen, and neurotrophins may be integrated is through the CREB binding protein (CBP) ( Arany et al., 1994 ).”
Background
Enhanced Kat3A/Catenin transcription: a common mechanism of therapeutic resistance
Bild, A. H., Teo, J.-L., & Kahn, M. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.32 · Cited by 2
“CBP and p300 retain extremely high identity, up to 93%, particularly over a large central core that includes the CH1, KIX, Bromodomain, and CH2 and CH3 regions [Figure 5], despite diverging over 450 million years ago([128,129]).”
Background
Viral genes that modulate apoptosis
Hardwick, J. M., Ketner, G. W., & Clem, R. J. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5287-1_9 · Cited by 2
Polyoma virus middle t-antigen: growth factor receptor mimic
Nicholson, P. R., & Dilworth, S. M. (2001) · Perspectives in medical virology · doi:10.1016/s0168-7069(01)05004-2 · Cited by 2
Efficiency and Fidelity of Site-Directed Mutagenesis with Complementary Primer Pairs
Varela‐Castillo, P., Razavi, A., Mousavi, N., Robinson, N., & Xiang-Jiao, Y. (2026) · Cells · doi:10.3390/cells15020138 · Cited by 1
“In the superfamily of lysine acetyltransferases encoded by the human genome, p300 and CBP are the largest, each possessing ~2400 residues [50–53].”
Discovery of CZL-149: A Novel, Highly Potent, and Orally Bioavailable Dual Inhibitor Targeting BET and p300/CBP Bromodomains with Strong Antitumor Efficacy
Chen, Z., Shi, Q., Zhang, Y., Wang, H., Li, Z., Zhang, Y., zhang, C., Wang, Y., Shen, H., Ding, J., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c00468 · Cited by 1
Rapid Identification of a Potent, Selective, and Orally Active p300/CBP Bromodomain Inhibitor Bearing an Imidazo[1,2- a ]pyridine Scaffold via a Highly Efficient Four-Step Synthesis
Chen, Z., Zhang, Y., Li, Z. Y., Shen, H., Wang, H., Yang, H., zhang, C., Hu, J., Wang, Y., Shi, Q., et al. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03730 · Cited by 1
Histone Acetyltransferases, Key Writers of the Epigenetic Language
Yang, X. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802389-1.00001-0 · Cited by 1
CBP knockdown inhibits angiotensin II-induced vascular smooth muscle cells proliferation through downregulating NF-kB transcriptional activity
JiangSi-si, Y., Chen, C., XuWan-qiang, S.-K., & Wang, L.-C. (2010) · Cited by 1
Rubinstein Taybi Syndrome
Das, N., Ghosh, N., Biswas, S., & Nayek, K. (2013) · Journal of Nepal Paediatric Society · doi:10.3126/jnps.v33i1.7091 · Cited by 1
A Novel Transcriptional Repression Domain Mediates p21 WAF1/CIP1 Induction of p300 Transactivation
(2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5360a-5360a.2000 · Cited by 1
“5, and 100 ng for Gal4 alone, Gal4 CBP, Gal4 CBP (1-1097), and Gal4 CBP (1098-2441), respectively (C); and 25, 10, 10, and 50 ng for Gal4 alone, Gal4 CBP, Gal4 CBP (1-1097), and Gal4 CBP (1098-2441), respectively (D).”
BackgroundMethodInfluential
Cyclic Adenosine Monophosphate Regulation of Gene Transcription
Montminy, M., & Ferreri, K. (1998) · Comprehensive physiology · doi:10.1002/cphy.cp070113 · Cited by 1
Avaliação da imunocompetência de portadores da síndrome de Rubinstein-taybi.
Torres, L. C. (2008) · doi:10.11606/t.42.2008.tde-01092008-192345 · Cited by 1
PCAF Lysine Acetyltransferase
You, L., & Yang, X. (2012) · Springer eBooks · doi:10.1007/978-1-4419-0461-4_511 · Cited by 1
Transcriptional Response to cAMP in the Liver
Fazia, M. A. D., Servillo, G., & Sassone‐Corsi, P. (2005) · Springer eBooks · doi:10.1007/3-540-27194-5_23 · Cited by 1
“Protein p300 shares similar regulatory functions to CBP [2, 28] in differentiation [30], cell growth [29], apoptosis and DNA repair [39].”
Background

Authors: Arany, Z.
Affiliations: Harvard University (US)
Corresponding author: Arany, Z
ORCID: Arany, Z
Venue: Cell
Publisher: Elsevier BV
Published: 1994-06-17
Volume: 77
Issue: 6
Pages: 799-800
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90127-9
OpenAlex: W2087880580
Cited by: 444
References: 10
Citations by year: 2026: 8 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 7
FWCI: 13.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: P300, CREB-binding protein, CBP, transcriptional coactivator, CREB
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Trans-Activators, Conserved Sequence, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Adenovirus E1A Proteins, E1A-Associated p300 Protein, CREB-Binding Protein

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

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