Cited by 444Genomics and Chromatin DynamicsChromatin Remodeling and CancerSignaling Pathways in Disease

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

Arany, Z·1994·Cell

DOI 10.1016/0092-8674(94)90127-9

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Transcriptional Coactivator Protein p300
Thompson, P. R., Kurooka, H., Nakatani, Y., & Cole, P. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104736200 · Cited by 134
CBP/p300 and muscle differentiation: no HAT, no muscle
Polesskaya, A., Naguibneva, I., Fritsch, L., Duquet, A., Ait‐Si‐Ali, S., Robin, P., Vervisch, A., Pritchard, L. L., Cole, P., & Harel‐Bellan, A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6816 · Cited by 134
Simple histone acetylation plays a complex role in the regulation of gene expression
Fukuda, H. (2006) · Briefings in Functional Genomics and Proteomics · doi:10.1093/bfgp/ell032 · Cited by 133
“GCN5 [11] and p300/CBP [12–14]) were also isolated and characterized [15, 16].”
Background
Glucagon Gene Transcription Activation Mediated by Synergistic Interactions of pax-6 and cdx-2 with the p300 Co-activator
Hussain, M. A., & Habener, J. F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28950 · Cited by 129
Abrogation of growth arrest signals by human papillomavirus type 16 E7 is mediated by sequences required for transformation
Demers, G. W., Espling, E., Harry, J. B., Etscheid, B. G., & Galloway, D. A. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6862-6869.1996 · Cited by 129
“This region of E1a can bind to p300 (18), a CREB-related transcription factor ( 2 ).”
BackgroundMethod
SV40 large T antigen functions in DNA replication and transformation
Simmons, D. T. (2000) · Advances in virus research · doi:10.1016/s0065-3527(00)55002-7 · Cited by 129
p300/CBP is required for transcriptional induction by interleukin-4 and interacts with Stat6
Gingras, S., Simard, J., Groner, B., & Pfitzner, E. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.13.2722 · Cited by 129
miR-34b Targets Cyclic AMP–Responsive Element Binding Protein in Acute Myeloid Leukemia
Pigazzi, M., Manara, E., Baron, E., & Basso, G. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3404 · Cited by 130
CREB-binding Protein/p300 Activates MyoD by Acetylation
Polesskaya, A., Duquet, A., Naguibneva, I., Weise, C., Vervisch, A., Bengal, E., Hucho, F., Robin, P., & Harel‐Bellan, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003815200 · Cited by 130
A Novel Transcriptional Repression Domain Mediates p21WAF1/CIP1 Induction of p300 Transactivation
Snowden, A. W., Anderson, L. A., Webster, G., & Perkins, N. D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2676-2686.2000 · Cited by 126
“5, and 100 ng for Gal4 alone, Gal4 CBP, Gal4 CBP (1-1097), and Gal4 CBP (1098-2441), respectively (C); and 25, 10, 10, and 50 ng for Gal4 alone, Gal4 CBP, Gal4 CBP (1-1097), and Gal4 CBP (1098-2441), respectively (D).”
BackgroundMethodInfluential
MicroRNA‐182 targets cAMP‐responsive element‐binding protein 1 and suppresses cell growth in human gastric adenocarcinoma
Kong, W., Bai, R., Liu, T., Cai, C., Liu, M., Li, X., & Tang, H. (2012) · FEBS Journal · doi:10.1111/j.1742-4658.2012.08519.x · Cited by 124
How the Rb tumor suppressor structure and function was revealed by the study of Adenovirus and SV40
DeCaprio, J. A. (2009) · Virology · doi:10.1016/j.virol.2008.12.010 · Cited by 126
YY1 represses human papillomavirus type 16 transcription by quenching AP-1 activity
O’Connor, M. J., Tan, S., Tan, C. H., & Bernard, H. (1996) · Journal of Virology · doi:10.1128/jvi.70.10.6529-6539.1996 · Cited by 126
Repression of GCN5 Histone Acetyltransferase Activity via Bromodomain-Mediated Binding and Phosphorylation by the Ku–DNA-Dependent Protein Kinase Complex
Barlev, N. A., Poltoratsky, V. P., Owen‐Hughes, T., Ying, C. Y., Liu, L., Workman, J. L., & Berger, S. L. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.3.1349 · Cited by 125
Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia
Nibbeling, E. A. R., Duarri, A., Verschuuren‐Bemelmans, C. C., Fokkens, M. R., Karjalainen, J. M., Smeets, C. J. L. M., de Boer-Bergsma, J. J., van der Vries, G. B., Dooijes, D., Bampi, G., et al. (2017) · Brain · doi:10.1093/brain/awx251 · Cited by 123
“The fact that novel genes FAT1 and EP300 , both known to be involved in transcription regulation (Arany et al. , 1994; Morris et al. , 2013; Ahmed et al. , 2015), are part of these clusters validates the methodology.”
Differential Transcriptional Activation by Human T-Cell Leukemia Virus Type 1 Tax Mutants Is Mediated by Distinct Interactions with CREB Binding Protein and p300
Bex, F., Yin, M.-J., Burny, A., & Gaynor, R. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2392 · Cited by 121
Distinct roles for P-CREB and LEF-1 in TCR alpha enhancer assembly and activation on chromatin templates in vitro.
Mayall, T. P., Sheridan, P. L., Montminy, M. R., & Jones, K. A. (1997) · Genes & Development · doi:10.1101/gad.11.7.887 · Cited by 118
Selective activation of PPARγ in skeletal muscle induces endogenous production of adiponectin and protects mice from diet-induced insulin resistance
Amin, R., Mathews, S. T., Camp, H. S., Ding, L., & Leff, T. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00446.2009 · Cited by 120
“The CR1 domain binds strongly to the transcriptional coactivator p300 (1, 15).”
Background
Creb-Binding Protein (Cbp/P300) and RNA Polymerase II Colocalize in Transcriptionally Active Domains in the Nucleus
von Mikecz, A. H., Zhang, S., Montminy, M., Tan, E. M., & Hemmerich, P. H. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.1.265 · Cited by 120
“…transcription factors suggested that these coactivators function as signal integrators by coordinating complex signal transduction events at the transcriptional level (Chrivia et al., 1993; Arany et al., 1994; Arias et al., 1994; Kwok et al., 1994; Eckner et al., 1994; Lundblad et al., 1995).”
Background
Adenovirus and cell cycle control
Ben-Israel, H. (2002) · Frontiers in bioscience · doi:10.2741/ben · Cited by 117
“The p300 sequence is highly homologous to the CREB-binding protein (CBP) (35) and both proteins are transcriptional coactivators involved in many physiological processes, including proliferation, differentiation and apoptosis (reviewed in (94)).”
Phosphorylation of p300 at Serine 89 by Protein Kinase C
Yuan, L. W., & Gambee, J. E. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007832200 · Cited by 119
Structural and Functional Analysis of Yeast Putative Adaptors
Candau, R., & Berger, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.5237 · Cited by 117
The CBP co-activator stimulates E2F1/DP1 activity
Trouche, D. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4139 · Cited by 120
Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)
Liang, G., & Hai, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.24088 · Cited by 114
The PHD Type Zinc Finger Is an Integral Part of the CBP Acetyltransferase Domain
Kalkhoven, E., Teunissen, H., Houweling, A., Verrijzer, C. P., & ZANTEMA, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.1961-1970.2002 · Cited by 114
Functional Association between CBP and HNF4 inTrans-activation
Yoshida, E., Aratani, S., Itou, H., Miyagishi, M., Takiguchi, M., Osumu, T., Murakami, K., & Fukamizu, A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7871 · Cited by 104
Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes
Dallas, P. B., Yaciuk, P., & Moran, E. M. (1997) · Journal of Virology · doi:10.1128/jvi.71.2.1726-1731.1997 · Cited by 101
The Myb oncoprotein: regulating a regulator
Ness, S. A. (1996) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00027-3 · Cited by 101
Myb binding proteins: regulators and cohorts in transformation
Ness, S. A. (1999) · Oncogene · doi:10.1038/sj.onc.1202726 · Cited by 98
“CBP or CREB-Binding Protein and its close relative p300 are ubiquitous coactivators that interact with a variety of transcription factors as well as numerous transforming proteins (Arany et al., 1994).”
Background
The Viral Oncoprotein E1A Blocks Transforming Growth Factor β-Mediated Induction of p21/WAF1/Cip1 and p15/INK4B
Datto, M., Hu, P. P.-C., Kowalik, T. F., Yingling, J. M., & Wang, X. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.4.2030 · Cited by 98
“In addition to its ability to bind Rb and Rb family members, E1A also binds to the transcriptional coactivator, p300 (2, 12).”
Background
The CREB-binding Protein (CBP) Cooperates with the Serum Response Factor for Transactivation of the c-fos Serum Response Element
Ramírez-Clavijo, S. R., Ait‐Si‐Ali, S., Robin, P., Trouche, D., & Harel‐Bellan, A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31016 · Cited by 96
Phosphorylation of the adenovirus E1A‐associated 300 kDa protein in response to retinoic acid and E1A during the differentiation of F9 cells.
Kitabayashi, I., Eckner, R., Arany, Z. P., Chiu, R., Gachelin, G., Livingston, D. M., & Yokoyama, K. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07356.x · Cited by 95
Self-citation
Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry
Bonapace, I. M., Latella, L., Papait, R., Nicassio, F., Sacco, A., Muto, M., Crescenzi, M., & Fiore, P. P. D. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200201025 · Cited by 97
“Key words: Np95; cell cycle; E1A; pRb; cycE–cdk2 910 The Journal of Cell Biology | Volume 157, Number 6, 2002 multiple interactions with key components of cellular growthregulatory pathways, including retinoblastoma protein (pRb)family proteins (the so-called pocket proteins) and the transcriptional coactivators p300…”
BackgroundInfluential
cAMP-Dependent Regulation of Gene Transcription by cAMP Response Element-Binding Protein and cAMP Response Element Modulator
Habener, J. F., Miller, C. P., & Vallejo, M. (1995) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61037-7 · Cited by 93
Induction of DNA synthesis and apoptosis in cardiac myocytes by E1A oncoprotein.
Liu, Y., & Kitsis, R. N. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.133.2.325 · Cited by 93
“…transcriptional adaptor molecules that are thought to transactivate the expression of target genes by interacting simultaneously with specific enhancer binding proteins and components of the basal transcriptional apparatus (Eckner et al., 1994; discussed in Arany et al., 1994).”
Background
Lysophosphatidylcholine induces rapid recruitment and activation of macrophages in the adult mouse spinal cord
Ousman, S. S., & David, S. (2000) · Glia · doi:10.1002/(sici)1098-1136(200003)30:1 · Cited by 209
The PCAF acetylase complex as a potential tumor suppressor
Schiltz, R. L., & Nakatani, Y. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(99)00037-2 · Cited by 90
p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cellsPreprint
Kawasaki, H., Song, J., Eckner, R., Ugai, H., Chiu, R., Taira, K., Shi, Y., Jones, N., & Yokoyama, K. K. (1998) · Genes & Development · doi:10.1101/gad.12.2.233 · Cited by 91
“…of chondrodysplasia and neurological abnormalities (Reimond et al. 1996). p300 and the related CBP (CREB-binding protein; Chrivia et al. 1993; Arany et al 1994, 1995; Eckner et al. 1994; Kwok et al. 1994), referred to below as p300/CBP, are highly homologous proteins that were originally…”
Background
SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression
Wen, J., Huang, S., Rogers, H. M., Dickinson, L. A., Kohwi-shigematsu, T., & Noguchi, C. T. (2004) · Blood · doi:10.1182/blood-2004-08-2988 · Cited by 89
Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
Xiao, Y., Li, B., Zhou, Z., Hancock, W. W., Zhang, H., & Greene, M. I. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.08.013 · Cited by 92
“They contain one bromodomain frequently found in mammalian HAT, three cysteine-histine (CH) rich domain, a KIX domain and glutamine-rich C terminus domain that all serve as docking modules for many transcriptional factors, and an acetyltransferase domain located in the middle of CBP/ p300 [68].”
Background
p300/CREB Binding Protein-Related Protein p270 Is a Component of Mammalian SWI/SNF Complexes
Dallas, P. B., Cheney, I. W., Liao, D.-W., Bowrin, V., Byam, W., Pacchione, S. J., Kobayashi, R., Yaciuk, P., & Morán, E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3596 · Cited by 89
p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis
Chiou, S., & White, E. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.3515-3525.1997 · Cited by 88
“Alternatively, p300 may regulate p53 turnover indirectly through its role as a transcriptional coactivator (2) which E1A perturbs.”
Background
Nuclear structure-gene expression interrelationships: implications for aberrant gene expression in cancer.
Stein, G. S., Montecino, M. A., van Wijnen, A. J., Stein, J. L., & Lian, J. B. (2000) · PubMed · Cited by 84
The yeast BDF1 gene encodes a transcription factor involved in the expression of a broad class of genes including snRNAs
Lygerou, Z., Conesa, C., Lesage, P., Swanson, R. N., Ruet, A., Carlson, M., Sentenac, A., & Séraphin, B. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.24.5332 · Cited by 87
Combinatorial regulation of transcription I: General aspects of transcriptional control
Ernst, P., & Smale, S. T. (1995) · Immunity · doi:10.1016/1074-7613(95)90139-6 · Cited by 84
An Enhancer Polymorphism at the Cardiomyocyte Intercalated Disc Protein NOS1AP Locus Is a Major Regulator of the QT Interval
Kapoor, A., Sekar, R. B., Hansen, N. F., Fox-Talbot, K., Morley, M. P., Pihur, V., Chatterjee, S., Brandimarto, J., Moravec, C. S., Pulit, S. L., et al. (2014) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2014.05.001 · Cited by 85
Role of the CBP catalytic core in intramolecular SUMOylation and control of histone H3 acetylation
Park, S., Stanfield, R. L., Martinez‐Yamout, M. A., Dyson, H. J., Wilson, I. A., & Wright, P. E. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703105114 · Cited by 81
Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38MAPK signaling pathways
Han, J., Macarak, E. J., Rosenbloom, J., Chung, K. C., & Chaqour, B. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03723.x · Cited by 82
“Both CREB and AP-1 promote gene transcription through association with their specific DNA binding sites in the promoters of their targeted genes [39–41].”
Background
The transcriptional coactivator CBP/p300 is an evolutionarily conserved node that promotes longevity in response to mitochondrial stress
Li, T. Y., Sleiman, M. B., Li, H., Gao, A. W., Mottis, A., Bachmann, A. M., Alam, G. E., Li, X., Goeminne, L. J. E., Schoonjans, K., et al. (2021) · Nature Aging · doi:10.1038/s43587-020-00025-z · Cited by 78
Regulation of Apoptosis by Adenovirus E1A and E1B Oncogenes
White, E. (1998) · Seminars in Virology · doi:10.1006/smvy.1998.0155 · Cited by 80
Modulating the masters: chemical tools to dissect CBP and p300 function
Breen, M. E., & Mapp, A. K. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.06.005 · Cited by 77
“This sequence conservation is particularly within the conserved activator-binding domains (93% sequence identity for TAZ1, 90% sequence identity for KIX) [5,6].”
Background
The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR
Masselink, H., & Bernards, R. (2000) · Oncogene · doi:10.1038/sj.onc.1203421 · Cited by 79
“E1A interacts with various chromatin modifying proteins, (reviewed by Mymryk and Smith, 1997), some of which display histone acetyltransferase (HAT) activity, such as the transcriptional coactivators CBP/p300 (Ogryzko et al., 1996) and TAFII-250 (Geisberg et al., 1995; Mizzen et al., 1996).”
BackgroundInfluential
Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis
Shisler, J. L., Duerksen-Hughes, P. J., Hermiston, T. M., Wold, W. S. M., & Gooding, L. R. (1996) · Journal of Virology · doi:10.1128/jvi.70.1.68-77.1996 · Cited by 77
Phosphodiesterase type IV inhibition prevents sequestration of CREB binding protein, protects striatal parvalbumin interneurons and rescues motor deficits in the R6/2 mouse model of Huntington’s disease
Giampà, C., Middei, S., Patassini, S., Borreca, A., Marullo, F., Laurenti, D., Bernardi, G., Ammassari‐Teule, M., & Fusco, F. R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06649.x · Cited by 78
“factor, referred to as the KIX domain, the bromodomain, the histone acetylase domain and the steroid receptor coactivator-1 interaction domain (Arany et al., 1994).”
Background
Signal transduction and the u-PA/u-PAR system
Besser, D., Verde, P., Nagamine, Y., & Blasi, F. (1996) · Fibrinolysis and Proteolysis · doi:10.1016/s0268-9499(96)80018-x · Cited by 77
Virus-Induced Apoptosis
Hardwick, J. M. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61063-7 · Cited by 76
A238L Inhibits NF-ATc2, NF-κB, and c-Jun Activation through a Novel Mechanism Involving Protein Kinase C-θ-Mediated Up-Regulation of the Amino-Terminal Transactivation Domain of p300
Granja, A. G., Perkins, N. D., & Revilla, Y. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2429 · Cited by 72
“E-mail address: yrevilla@cbm.uam.es 3 Abbreviations used in this paper: CBP, CREB-binding protein; BCA, bicinchoninic acid; DAPI, 4 ,6 -diamidino-2-phenylindole; DBD, DNA-binding domain; HAT, histone acetyl transferase; Ion, calcium ionophore; MBP, myosin-binding protein; PKC, protein kinase C; RIPA, radioimmunoprecip…”
BackgroundInfluential
Control of Cardiac-specific Transcription by p300 through Myocyte Enhancer Factor-2D
Slepak, T. I., Webster, K. A., Zang, J., Prentice, H. M., O'Dowd, A., Hicks, M. N., & Bishopric, N. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004625200 · Cited by 74
Suppression of the p300-dependent mdm2negative-feedback loop induces the p53 apoptotic functionPreprint
Thomas, A. E., & White, E. (1998) · Genes & Development · doi:10.1101/gad.12.13.1975 · Cited by 72
“For p300 transfections, p53A cells were electroporated with 12 or 24 µg of pCMVb alone, pCMVbp300, or pCMVp300D30 mutant (deletion in E1A-interacting domain) (Arany et al. 1994).”
BackgroundMethod
CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis
Bartolotti, N., & Lazarov, O. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.01.004 · Cited by 70
“CBP and p300 are transcriptional coactivators for CREB that are similar both in sequence and in function, and are necessary for CRE-based gene transcription (Arany et al., 1994; Chrivia et al., 1993).”
Background
Steroid Receptor Coactivator-1 Interacts with Serum Response Factor and Coactivates Serum Response Element-mediated Transactivations
Kim, H.-J., Kim, J., & Lee, J. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.44.28564 · Cited by 71
mUBC9, a Novel Adenovirus E1A-interacting Protein That Complements a Yeast Cell Cycle Defect
Hateboer, G., Hijmans, E. M., Nooij, J. B. D., Schlenker, S., Jentsch, S., & Bernards, R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.25906 · Cited by 71
Transcription regulation and human diseases
Villard, J. (2004) · Swiss Medical Weekly · doi:10.4414/smw.2004.10191 · Cited by 68
Histone Modification Therapy of Cancer
Biancotto, C., Frigè, G., & Minucci, S. (2010) · Advances in genetics · doi:10.1016/b978-0-12-380866-0.60013-7 · Cited by 74
Cell Cycle Regulation of the Transcriptional Coactivators p300 and CREB Binding Protein
Snowden, A. W., & Perkins, N. D. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00020-3 · Cited by 68
Epigenetic moonlighting: Catalytic-independent functions of histone modifiers in regulating transcription
Morgan, M. A., & Shilatifard, A. (2023) · Science Advances · doi:10.1126/sciadv.adg6593 · Cited by 71
Oncolytic Virotherapy: Approaches to Tumor Targeting and Enhancing Antitumor Effects
Thorne, S. H., Hermiston, T. W., & Kirn, D. H. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2005.09.007 · Cited by 64
E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity
Wang, H. G., Moran, E. M., & Yaciuk, P. (1995) · Journal of Virology · doi:10.1128/jvi.69.12.7917-7924.1995 · Cited by 64
Viral oncoprotein binding to pRB, p107, p130, and p300
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A Novel Mechanism for Cyclic Adenosine 3',5'-Monophosphate Regulation of Gene Expression by CREB-Binding Protein
Zanger, K., Cohen, L. E., Hashimoto, K., Radovick, S., & Wondisford, F. E. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.2.0245 · Cited by 63
Novel Heart Failure Therapy Targeting Transcriptional Pathway in Cardiomyocytes by a Natural Compound, Curcumin
Morimoto, T., Sunagawa, Y., Fujita, M., & Hasegawa, K. (2010) · Circulation Journal · doi:10.1253/circj.cj-09-1012 · Cited by 60
Transcriptional regulation of inflammatory secreted phospholipases A2
Andréani, M., Olivier, J. L., Berenbaum, F., Raymondjean, M., & Bereziat, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00117-7 · Cited by 63
Retinoid receptors in transcriptional regulation
Minucci, S., & Ozato, K. (1996) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(96)80085-2 · Cited by 61
Mechanisms of Transcriptional Regulation of Cellular Genes by SV40 Large T- and Small T-Antigens
Moens, U. L., Seternes, O. M., Johansen, B., & Rekvig, O. P. (1997) · Virus Genes · doi:10.1023/a:1007962908248 · Cited by 63
Creb5 establishes the competence for Prg4 expression in articular cartilage
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CYNTENATOR: Progressive Gene Order Alignment of 17 Vertebrate Genomes
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“The P300 gene encodes an acetyltransferase and transcriptional coactivator which constitutes a general component of enhancer-associated protein complexes and is required for embryonic development [32,33].”
Background
The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
Gargaro, M., Scalisi, G., Manni, G., Mondanelli, G., Grohmann, U., & Fallarino, F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020757 · Cited by 64
“They function as coregulators and also as HATs [133,134].”
Background
Estrogen receptors in human myeloma cells.
Otsuki, T., Yamada, O., Kurebayashi, J., Moriya, T., Sakaguchi, H., Kunisue, H., Yata, K., Uno, M., Yawata, Y., & Ueki, A. (2000) · PubMed · Cited by 61
Analysis and mapping of a family of 3'-coterminal transcripts containing coding sequences for human cytomegalovirus open reading frames UL93 through UL99
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“Interestingly, the recently cloned CREB-associated protein CBP has sequence homology with the E1A-associated p300 protein (4), which is itself a TFIID adaptor protein (27a).”
Background
CREB-independent regulation by CBP is a novel mechanism of human growth hormone gene expression
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Transcriptional Regulation of the Transforming Growth Factor-β2 Promoter by cAMP-responsive Element-binding Protein (CREB) and Activating Transcription Factor-1 (ATF-1) Is Modulated by Protein Kinases and the Coactivators p300 and CREB-binding Protein
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Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP.
Phillips, A. C., & Vousden, K. H. (1997) · Journal of General Virology · doi:10.1099/0022-1317-78-4-905 · Cited by 60
“Some of the transcriptional functions of E1A are related to the interaction with p300, a cellular protein which functions as a co-activator (Arany et al., 1994 ; Lundblad et al., 1995).”
Background
Transcriptional Modulation by the Adenovirus E1A Gene
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Steroid/nuclear receptor coactivators
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CBP and P300 regulate distinct gene networks required for human primary myoblast differentiation and muscle integrity
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The activity of cytosolic phospholipase A2 is required for the lysis of adenovirus-infected cells by tumor necrosis factor
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Multiple mechanisms of growth hormone-regulated gene transcription
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“Arany Z, Sellers WR, Livingston DM, Eckner R. E1A-associated p300 and CREB-associated CBP belong to a cnserved family of coactivators.”
Transcriptional coactivator cAMP response element binding protein mediates induction of the human proliferating cell nuclear antigen promoter by the adenovirus E1A oncoprotein
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CREB Binding Protein Functions During Successive Stages of Eye Development in Drosophila
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“…development have demonstrated roles for CBP in proper wing vein formation, dendritic andboth a “bridging” molecule and a transcriptional coactivator (Arany et al. 1994; Kwok et al. 1994; Kee et al. axonal morphogenesis, formation of the synapse, and the release of transmitters at the…”
Background
Acetyltransferase machinery conserved in p300/CBP-family proteins
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“Thus, they were proposed to belong to the same protein family (Arany et al., 1994).”
Background
Aryl Hydrocarbon Receptor Is Required for p300-Mediated Induction of DNA Synthesis by Adenovirus E1A
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Review: IRF Regulation of HIV-1 Long Terminal Repeat Activity
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“(100,101) 106) As a critical determinant of its coactivator activity, CBP/p300 possesses histone acetyltransferase activity.”
Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A
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cAMP-response-element-binding protein positively regulates breast cancer metastasis and subsequent bone destruction
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“Phosphorylation at Ser133 by various serine/threonine protein kinases promotes the recruitment of transcriptional co-activators, CREB-binding protein and p300, thus allowing CREB-dependent gene transcription [3,5].”
Background
Transcriptional Co-activator p300 Maintains Basal Hepatic Gluconeogenesis
He, L., Naik, K., Meng, S., Cao, J., Sidhaye, A. R., Ma, A., Radovick, S., & Wondisford, F. E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.385864 · Cited by 47
“CBP and p300 are closely related proteins that share extensive homology at the amino acid level (~60%), including three cysteine–histidine rich domains (CH1-3), the CREB binding domain (KIX domain), the bromodomain, the HAT (histone acetyltransferase) domain and the SID (steroid receptor co-activator interacting domai…”
Background
Kat3 coactivators in somatic stem cells and cancer stem cells: biological roles, evolution, and pharmacologic manipulation
Thomas, P. D., & Kahn, M. (2016) · Cell Biology and Toxicology · doi:10.1007/s10565-016-9318-0 · Cited by 48
“(Arany et al. 1994; Eckner et al. 1994).”
Insights into regulators of p53 acetylation
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“These two proteins have highly conserved regions and show 63% homology at the amino-acid level [23].”
Background
Understanding the acetylome: translating targeted proteomics into meaningful physiology
Philp, A., Rowland, T., Pérez‐Schindler, J., & Schenk, S. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00399.2013 · Cited by 48
A Long Noncoding RNA, Antisense IL-7, Promotes Inflammatory Gene Transcription through Facilitating Histone Acetylation and Switch/Sucrose Nonfermentable Chromatin Remodeling
Liu, X., Lu, Y., Zhu, J., Liu, M., Xie, M., Ye, M., Li, M., Wang, S., Ming, Z., Tong, Q., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1900256 · Cited by 46
“Considering the function of CBP and p300 is largely redundant (28), we investigated whether p300 and PCAF are involved in IL-7–AS–modulated expression of CCL2, CCL5, CCL7, and IL-6 in cells following LPS stimulation.”
Background

Authors: Arany, Z.
Affiliations: Harvard University (US)
Corresponding author: Arany, Z
ORCID: Arany, Z
Venue: Cell
Publisher: Elsevier BV
Published: 1994-06-17
Volume: 77
Issue: 6
Pages: 799-800
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90127-9
OpenAlex: W2087880580
Cited by: 444
References: 10
Citations by year: 2026: 8 · 2025: 10 · 2024: 7 · 2023: 9 · 2022: 2 · 2021: 11 · 2020: 7 · 2019: 7 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 10 · 2014: 13 · 2013: 7 · 2012: 7
FWCI: 13.56
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: P300, CREB-binding protein, CBP, transcriptional coactivator, CREB
MeSH terms: Amino Acid Sequence, Animals, Humans, Molecular Sequence Data, Nuclear Proteins, Transcription Factors, Trans-Activators, Conserved Sequence, Cyclic AMP Response Element-Binding Protein, Sequence Homology, Amino Acid, Adenovirus E1A Proteins, E1A-Associated p300 Protein, CREB-Binding Protein

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E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

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