The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.
Abstract
We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It is important to point out that the only exceptional case, namely that of the mGluR1 mutant mice, is complicated by the fact that two groups have generated and analyzed these mutants independently and have obtained opposing results (Aiba et al., 1994; Conquet et al., 1994; Chen and Tonegawa, 1997).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Aiba et al., 1994
In the citing paper
“Numerous studies, using lesioning (Kim and Fanselow, 1992;Phillips and LeDoux, 1992) and genetic (Aiba et al., 1994;Tsien et al., 1996) strategies, indicated that the hippocampus plays a crucial role in context-dependent fear conditioning.”
From Modulation of learning and anxiety by corticotropin-releasing factor (CRF) and stress: differential roles of CRF receptors 1 and 2 (1999) · cites this paper as Aiba et al., 1994
Citations
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.
Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292
Molecular diversity of glutamate receptors and implications for brain function
Nakanishi, S. (1992) · Science · doi:10.1126/science.1329206 · Cited by 2,543
Modality-Specific Retrograde Amnesia of Fear
Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483
Dudek, S. M., & Bear, M. F. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.10.4363 · Cited by 1,708
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,366
Sequence and expression of a metabotropic glutamate receptor
Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., & Nakanishi, S. (1991) · Nature · doi:10.1038/349760a0 · Cited by 1,216
Impaired Long-Term Potentiation, Spatial Learning, and Hippocampal Development in fyn Mutant Mice
Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P. M., & Kandel, E. R. (1992) · Science · doi:10.1126/science.1361685 · Cited by 1,160
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
Blanton, M. G., Turco, J. J. L., & Kriegstein, A. R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90131-3 · Cited by 945
Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
Aiba, A., Kano, M., Chen, C., Stanton, M. E., Fox, G. D., Herrup, K., Zwingman, T. A., & Tonegawa, S. (1994) · Cell · doi:10.1016/0092-8674(94)90205-4 · Cited by 930
Self-citationBaude, A., Nusser, Z., Roberts, J. D. B., Mulvihill, E., Jeffrey Mcllhinney, R. A., & Somogyi, P. (1993) · Neuron · doi:10.1016/0896-6273(93)90086-7 · Cited by 927
The hippocampus—what does it do?
Eichenbaum, H., Otto, T., & Cohen, N. J. (1992) · Behavioral and Neural Biology · doi:10.1016/0163-1047(92)90724-i · Cited by 867
Metabotropic glutamate receptors in brain function and pathology
Schoepp, D. D., & Conn, P. J. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90107-u · Cited by 791
Induction of LTP in the hippocampus needs synaptic activation of glutamate metabotropic receptors
Bashir, Z. I., Bortolotto, Z. A., Davies, C. H., Berretta, N., Irving, A. J., Seal, A., Henley, J. M., Jane, D. E., Watkins, J. C., & Collingridge, G. L. (1993) · Nature · doi:10.1038/363347a0 · Cited by 733
O’Hara, P. J., Sheppard, P. O., Thøgersen, H., Venezia, D., Haldeman, B. A., McGrane, V., Houamed, K. M., Thomsen, C., Gilbert, T., & Mulvihill, E. R. (1993) · Neuron · doi:10.1016/0896-6273(93)90269-w · Cited by 710
Shigemoto, R., Nakanishi, S., & Mizuno, N. (1992) · The Journal of Comparative Neurology · doi:10.1002/cne.903220110 · Cited by 644
Cellular localization of a metabotropic glutamate receptor in rat brain
Martin, L. J., Blackstone, C. D., Huganir, R. L., & Price, D. L. (1992) · Neuron · doi:10.1016/0896-6273(92)90165-a · Cited by 552
PKCγ mutant mice exhibit mild deficits in spatial and contextual learning
Abeliovich, A., Paylor, R. E., Chen, C., Kim, J. J., Wehner, J. M., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90614-v · Cited by 540
Modified hippocampal long-term potentiation in PKCγ-mutant mice
Abeliovich, A., Chen, C., Goda, Y., Silva, A. J., Stevens, C. F., & Tonegawa, S. (1993) · Cell · doi:10.1016/0092-8674(93)90613-u · Cited by 504
Postsynaptic Induction and Presynaptic Expression of Hippocampal Long-Term Depression
Bolshakov, V. Y., & Siegelbaum, S. A. (1994) · Science · doi:10.1126/science.7909958 · Cited by 486
Bortolotto, Z. A., Bashir, Z. I., Davies, C. H., & Collingridge, G. L. (1994) · Nature · doi:10.1038/368740a0 · Cited by 432
Baskys, A., & Malenka, R. C. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018901 · Cited by 430
Locally Distributed Synaptic Potentiation in the Hippocampus
Schuman, E. M., & Madison, D. V. (1994) · Science · doi:10.1126/science.8290963 · Cited by 352
Role of a metabotropic glutamate receptor in synaptic modulation in the accessory olfactory bulb
Hayashi, Y., Momiyama, A., Takahashi, T., Ohishi, H., Ogawa-Meguro, R., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1993) · Nature · doi:10.1038/366687a0 · Cited by 347
Hayashi, Y., Sekiyama, N., Nakanishi, S., Jane, D., SUNTER, D., Birse, E. F., UDVARHELYI, P., & Watkins, J. C. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03370.1994 · Cited by 319
Kim, J. J., DeCola, J. P., Landeira-Fernández, J., & Fanselow, M. S. (1991) · Behavioral Neuroscience · doi:10.1037/0735-7044.105.1.126 · Cited by 301
Raastad, M., Storm, J. F., & Andersen, P. N. (1992) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1992.tb00114.x · Cited by 250
Fotuhi, M., Sharp, A., Glatt, C., Hwang, P. M., von Krosigk, M., Snyder, S. H., & Dawson, T. M. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-05-02001.1993 · Cited by 247
Forsythe, I. D., & Clements, J. D. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018240 · Cited by 247
Kullmann, D. M., Perkei, D. J., Manabe, T., & Nicoll, R. A. (1992) · Neuron · doi:10.1016/0896-6273(92)90075-o · Cited by 237
Quisqualate receptor-mediated depression of calcium currents in hippocampal neurons
Lester, R. A. J., & Jahr, C. E. (1990) · Neuron · doi:10.1016/0896-6273(90)90200-y · Cited by 182
MCPG Antagonizes Metabotropic Glutamate Receptors but not Long‐term Potentiation in the Hippocampus
Manzoni, O. J., Weisskopf, M. G., & Nicoll, R. A. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00599.x · Cited by 181
Desai, M. A., & Conn, P. J. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.1.40 · Cited by 168
Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor
Swartz, K., & Bean, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-11-04358.1992 · Cited by 163
Birse, E. F., Eaton, S. A., Jane, D. E., Jones, P. L., Porter, R. H. P., Pook, P. C. K., Sunter, D. C., Udvarhelyi, P. M., Wharton, B., Roberts, P., et al. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90400-a · Cited by 143
Bashir, Z. I., Jane, D. E., Sunter, D. C., Watkins, J. C., & Collingridge, G. L. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)91009-c · Cited by 134
Rosenmund, C., & Westbrook, G. L. (1993) · The Journal of Physiology · doi:10.1113/jphysiol.1993.sp019884 · Cited by 133
Glutamate mediates a slow synaptic response in hippocampal slice cultures
Charpak, S., & Gähwiler, B. H. (1991) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1991.0035 · Cited by 133
Sahara, Y., & Westbrook, G. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-07-03041.1993 · Cited by 122
Chinestra, P., Aniksztejn, L., Diabira, D., & Ben‐Ari, Y. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.6.2684 · Cited by 115
Wyllie, D. J. A., Manabe, T., & Nicoll, R. A. (1994) · Neuron · doi:10.1016/0896-6273(94)90158-9 · Cited by 112
Sayer, R. J., Schwindt, P. C., & Crill, W. E. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.833 · Cited by 107
Westbrook, G. L. (1994) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(94)90094-9 · Cited by 92
Riedel, G., Wetzel, W., & Reymann, K. G. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)91047-2 · Cited by 76
Glutamate iontophoresis induces long-term potentiation in the absence of evoked presynaptic activity
Cormier, R. J., Mauk, M. D., & Kelly, P. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90206-7 · Cited by 38
Modified Hebbian Rule for Synaptic Enhancement in the Hippocampus and the Visual CortexPreprint
Bonhoeffer, T., Kossel, A. H., Bolz, J., & Aertsen, A. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.017 · Cited by 13
Cited by
Sorted by citations
Long-Term Potentiation and Memory
Lynch, M. A. (2004) · Physiological Reviews · doi:10.1152/physrev.00014.2003 · Cited by 2,074
Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
Niswender, C. M., & Conn, P. J. (2010) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.011008.145533 · Cited by 1,889
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
Glutamate receptors in the mammalian central nervous system
Ozawa, S., Kamiya, H., & Tsuzuki, K. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00085-3 · Cited by 1,133
Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P. J., Neki, A., Abe, T., Nakanishi, S., et al. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07503.1997 · Cited by 1,116
Metadata
- Authors
- Aiba, A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Aiba, A
- ORCID
- Aiba, A
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-10-21
- Volume
- 79
- Issue
- 2
- Pages
- 365-375
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1983956991
- Cited by
- 614
- References
- 49
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 21
- FWCI
- 16.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01 NS32925, R01NS020591, NS20591, R01NS032925)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- metabotropic glutamate receptor 1, hippocampal long-term potentiation, hippocampal CA1, synaptic plasticity, long-term depression, short-term potentiation, excitatory synaptic transmission, learning disabilities
- MeSH terms
- Animals, Base Sequence, Electric Stimulation, Female, Genes, Hippocampus, Male, Mice, Inbred C57BL, Molecular Sequence Data, Synaptic Transmission, Neuronal Plasticity, Restriction Mapping, Receptors, Glutamate, Long-Term Potentiation, DNA Primers, Mice, Knockout, Mice, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review