Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

Dudek, S M; Bear, M F

doi:10.1073/pnas.89.10.4363

Cited by 1,708Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

Open access

Dudek, S M, Bear, M F·1992·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.89.10.4363PMC PMC49082

Open this paper in CoChat — free account

Abstract

We tested a theoretical prediction that patterns of excitatory input activity that consistently fail to activate target neurons sufficiently to induce synaptic potentiation will instead cause a specific synaptic depression. To realize this situation experimentally, the Schaffer collateral projection to area CA1 in rat hippocampal slices was stimulated electrically at frequencies ranging from 0.5 to 50 Hz. Nine hundred pulses at 1-3 Hz consistently yielded a depression of the CA1 population excitatory postsynaptic potential that persisted without signs of recovery for greater than 1 hr after cessation of the conditioning stimulation. This long-term depression was specific to the conditioned input, ruling out generalized changes in postsynaptic responsiveness or excitability. Three lines of evidence suggest that this effect is accounted for by a modification of synaptic effectiveness rather than damage to or fatigue of the stimulated inputs. First, the effect was dependent on the stimulation frequency; 900 pulses at 10 Hz caused no lasting change, and at 50 Hz a synaptic potentiation was usually observed. Second, the depressed synapses continued to support long-term potentiation in response to a high-frequency tetanus. Third, the effects of conditioning stimulation could be prevented by application of NMDA receptor antagonists. Thus, our data suggest that synaptic depression can be triggered by prolonged NMDA receptor activation that is below the threshold for inducing synaptic potentiation. We propose that this mechanism is important for the modifications of hippocampal response properties that underlie some forms of learning and memory.

Integrity signals

Registry

Crossref · 10.1073/pnas.89.10.4363

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

The text we found for this paper looks like another document, so its claims and self-check weren’t run. The registry and citation checks still apply.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The text we found for this paper looks like another document, so the self-check wasn’t run.

Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex
Bienenstock, E., Cooper, L., & Munro, P. (1982) · The Journal of Neuroscience · doi:10.1523/jneurosci.02-01-00032.1982 · Cited by 2,896 · see citing works
A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory.
Lisman, J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.23.9574 · Cited by 1,127 · see citing works
Heterosynaptic depression: a postsynaptic correlate of long-term potentiation
LYNCH, G. S., DUNWIDDIE, T., & GRIBKOFF, V. (1977) · Nature · doi:10.1038/266737a0 · Cited by 615 · see citing works
Statistical factors involved in neuromuscular facilitation and depression
del Castillo, J., & Katz, B. (1954) · The Journal of Physiology · doi:10.1113/jphysiol.1954.sp005130 · Cited by 587 · see citing works
Synapses as associative memory elements in the hippocampal formation
Levy, W. B., & Steward, O. (1979) · Brain Research · doi:10.1016/0006-8993(79)91003-5 · Cited by 557 · see citing works
A Physiological Basis for a Theory of Synapse Modification
Bear, M. F., Cooper, L. N., & Ebner, F. F. (1987) · Science · doi:10.1126/science.3037696 · Cited by 528 · see citing works
Self-citation
Long‐term potentiation and depression of synaptic responses in the rat hippocampus: localization and frequency dependency.
Dunwiddie, T. V., & LYNCH, G. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012239 · Cited by 479 · see citing works
Associative long-term depression in the hippocampus induced by hebbian covariance
Stanton, P. K., & B, T. J. S. A. (1989) · Nature · doi:10.1038/339215a0 · Cited by 461 · see citing works
A long-term depression of AMPA currents in cultured cerebellar purkinje neurons
Linden, D. J., Dickinson, M. H., Smeyne, M., & Connor, J. A. (1991) · Neuron · doi:10.1016/0896-6273(91)90076-c · Cited by 418 · see citing works
The Influence of Prior Synaptic Activity on the Induction of Long-Term Potentiation
Huang, Y.-Y., Colino, A., Selig, D. K., & Malenka, R. C. (1992) · Science · doi:10.1126/science.1346729 · Cited by 412 · see citing works
Reversal of long-term potentiation (depotentiation) induced by tetanus stimulation of the input to CA1 neurons of guinea pig hippocampal slices.
Fujii, S., Saito, K., Miyakawa, H., Ito, K., & Kato, H. (1991) · Brain Research · doi:10.1016/0006-8993(91)90867-u · Cited by 375 · see citing works
Development of neuronal selectivity in primary visual cortex of cat.
Frégnac, Y., & Imbert, M. (1984) · Physiological Reviews · doi:10.1152/physrev.1984.64.1.325 · Cited by 336 · see citing works
The effects of repetitive low frequency stimulation on control and “potentiated” synaptic responses in the hippocampus
Barrionuevo, G., Schottler, F., & Lynch, G. (1980) · Life Sciences · doi:10.1016/0024-3205(80)90509-3 · Cited by 321 · see citing works
Neuroscience and Connectionist Theory
Gluck, M. A., & Rumelhart, D. E. (2013) · Psychology Press eBooks · doi:10.4324/9780203762981 · Cited by 320 · see citing works
Stable depression of potentiated synaptic responses in the hippocampus with 1–5 Hz stimulation
Staubli, U. V., & LYNCH, G. S. (1990) · Brain Research · doi:10.1016/0006-8993(90)91096-y · Cited by 301 · see citing works
Quantal analysis of excitatory synaptic action and depression in hippocampal slices
Larkman, A. U., Stratford, K. J., & Jack, J. (1991) · Nature · doi:10.1038/350344a0 · Cited by 197 · see citing works
A theory for the acquisition and loss of neuron specificity in visual cortex
Cooper, L. N., Liberman, F. Z., & Erkki Oja, A. (1979) · Biological Cybernetics · doi:10.1007/bf00337414 · Cited by 145 · see citing works
Intracellular injection of Ca2+ chelators blocks induction of long-term depression in rat visual cortex.
Bröcher, S., Artola, A., & Singer, W. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.123 · Cited by 140 · see citing works
The neural and molecular bases of learning
Bruyn, G. W. (1987) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(87)90195-x · Cited by 123 · see citing works
Synaptic plasticity in visual cortex: comparison of theory with experiment
Clothiaux, E. E., Bear, M. F., & Cooper, L. N. (1991) · Journal of Neurophysiology · doi:10.1152/jn.1991.66.5.1785 · Cited by 112 · see citing works
Self-citation
Exploration-dependent modulation of evoked responses in fascia dentata: dissociation of motor, EEG, and sensory factors and evidence for a synaptic efficacy change
Green, E., McNaughton, B. L., & Barnes, C. A. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-05-01455.1990 · Cited by 77 · see citing works
Long-term depression at synapses in slices of rat hippocampus can be induced by bursts of postsynaptic activity
Pockett, S., Brookes, N. H., & Bindman, L. J. (1990) · Experimental Brain Research · doi:10.1007/bf00228861 · Cited by 62 · see citing works
Regulation of efficacy at central synapses
Korn, H., Faber, D., Burnod, Y., et al. (1984) · Journal of Neuroscience · doi:10.1523/jneurosci.04-01-00125.1984 · Cited by 54 · see citing works
Stimulation of Phosphoinositide Turnover by Excitatory Amino Acids
Bear, M. F., & Dudek, S. M. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1991.tb25912.x · Cited by 34 · see citing works
Self-citation
[Facial myokymia caused by pontine lesions and central fever in multiple sclerosis--case report].
Gold, R., & Kappos, L. (1991) · PubMed · Cited by 2 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Gold R., Kappos L. Faziale Myokymie durch pontine Läsionen und zentrales Fieber bei multipler Sklerose--Kasuistik. Schweiz Rundsch Med Prax. 1991 Nov 19;80(47):1327–1329. [PubMed] [Google Scholar]

Sorted by citations

Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
Bi, G.-Q., & Poo, M.-M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10464.1998 · Cited by 4,744 · see citing works
Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685 · see citing works
CORTICAL PLASTICITY: From Synapses to Maps
Buonomano, D. V., & Merzenich, M. M. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.149 · Cited by 2,083 · see citing works
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782 · see citing works
The mGluR theory of fragile X mental retardation
Bear, M. F., Huber, K. M., & Warren, S. T. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.04.009 · Cited by 1,580 · see citing works
Self-citation
The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Huber, K. M., Gallagher, S. M., Warren, S. T., & Bear, M. F. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122205699 · Cited by 1,349 · see citing works
Self-citation
Involvement of a calcineurin/ inhibitor-1 phosphatase cascade in hippocampal long-term depression
Mulkey, R. M., Endo, S., Shenolikar, S., & Malenka, R. C. (1994) · Nature · doi:10.1038/369486a0 · Cited by 1,083 · see citing works
TrkB signalling pathways in LTP and learning
Minichiello, L. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2738 · Cited by 1,055 · see citing works
AMPAR Removal Underlies Aβ-Induced Synaptic Depression and Dendritic Spine Loss
Hsieh, H., Boehm, J., Sato, C., Iwatsubo, T., Tomita, T., Sisodia, S., & Malinow, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.10.035 · Cited by 1,042 · see citing works
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025 · see citing works
AMPARs and Synaptic Plasticity: The Last 25 Years
Huganir, R. L., & Nicoll, R. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.025 · Cited by 968 · see citing works
Long-term depression in the CNS
Collingridge, G. L., Peineau, S., Howland, J. G., & Wang, Y. T. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2867 · Cited by 926 · see citing works
Activation of p75NTR by proBDNF facilitates hippocampal long-term depression
Woo, N. H., Teng, H. K., Siao, C.-J., Chiaruttini, C., Pang, P. T., Milner, T. A., Hempstead, B. L., & Lu, B. (2005) · Nature Neuroscience · doi:10.1038/nn1510 · Cited by 815 · see citing works
Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity
Deisseroth, K., Bito, H., & Tsien, R. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80026-4 · Cited by 698 · see citing works
A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
Tang, A.-H., Chen, H., Li, T. P., Metzbower, S. R., MacGillavry, H. D., & Blanpied, T. A. (2016) · Nature · doi:10.1038/nature19058 · Cited by 677 · see citing works
Progesterone receptors: form and function in brain
Brinton, R. D., Thompson, R. F., Foy, M. R., Baudry, M., Wang, J., Finch, C. E., Morgan, T. E., Pike, C. J., Mack, W. J., Stanczyk, F. Z., et al. (2008) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2008.02.001 · Cited by 675 · see citing works
Regulation of NMDA receptor subunit expression and its implications for LTD, LTP, and metaplasticity
Yashiro, K., & Philpot, B. D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.046 · Cited by 649 · see citing works
Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.
Aiba, A. (1994) · Cell · doi:10.1016/0092-8674(94)90204-6 · Cited by 614 · see citing works
Impairment of Suckling Response, Trigeminal Neuronal Pattern Formation, and Hippocampal LTD in NMDA Receptor ε2 Subunit Mutant Mice
Kutsuwada, T., Sakimura, K., Manabe, T., Takayama, C., Katakura, N., Kushiya, E., Natsume, R., Watanabe, M., Inoue, Y., Yagi, T., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80051-3 · Cited by 498 · see citing works
Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory
Nagy, V., Bozdagi, O., Matynia, A., Balcerzyk, M., Okulski, P., Dzwonek, J., Costa, R. M., Silva, A. J., Kaczmarek, L., & Huntley, G. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4359-05.2006 · Cited by 499 · see citing works
A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · see citing works
Insulin signaling in the central nervous system: Learning to survive
van der Heide, L. P., Ramakers, G. M. J., & Smidt, M. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.06.003 · Cited by 444 · see citing works
Environment and Brain Plasticity: Towards an Endogenous Pharmacotherapy
Sale, A., Berardi, N., & Maffei, L. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2012 · Cited by 402 · see citing works
Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation
Murphy, K. P. S. J., Carter, R. J., Lione, L. A., Mangiarini, L., Mahal, A., Bates, G. P., Dunnett, S. B., & Morton, A. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05115.2000 · Cited by 398 · see citing works
The BCM theory of synapse modification at 30: interaction of theory with experiment
Cooper, L. N., & Bear, M. F. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3353 · Cited by 395 · see citing works
Self-citation
The sequential hypothesis of the function of sleep
Giuditta, A., Ambrosini, M. V., Montagnese, P., Mandile, P., Cotugno, M., Zucconi, G. G., & Vescia, S. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00012-i · Cited by 382 · see citing works
Long-term potentiation and long-term depression: a clinical perspective
Bliss, T. V. P., & Cooke, S. F. (2011) · Clinics · doi:10.1590/s1807-59322011001300002 · Cited by 333 · see citing works
Influence of subunit composition on desensitization of neuronal acetylcholine receptors at low concentrations of nicotine
Fenster, C. P., Rains, M. F., Noerager, B., Quick, M. W., & Lester, R. A. J. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-15-05747.1997 · Cited by 332 · see citing works
Modulation of long-term synaptic depression in visual cortex by acetylcholine and norepinephrine
Kirkwood, A., Rozas, C., Kirkwood, J., Perez, F., & Bear, M. F. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-05-01599.1999 · Cited by 315 · see citing works
Self-citation
Prefrontal-Hippocampal Interactions in Memory and Emotion
Jin, J., & Maren, S. (2015) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2015.00170 · Cited by 313 · see citing works
“These forms of plasticity are NMDA receptor-dependent and involve activation of serine/threonine kinases such as CaMKII, PKC, and PKA (Dudek and Bear, 1992; Bliss and Collingridge, 1993; Jay et al., 1995, 1998; Burette et al., 1997; Takita et al., 1999).”
Background
NMDA receptors and memory encoding
Morris, R. G. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.014 · Cited by 295 · see citing works
Hippocampal ripples down-regulate synapses
Norimoto, H., Makino, K., Gao, M., Shikano, Y., Okamoto, K., Ishikawa, T., Sasaki, T., Hioki, H., Fujisawa, S., & Ikegaya, Y. (2018) · Science · doi:10.1126/science.aao0702 · Cited by 262 · see citing works
Insulin modulates hippocampal activity‐dependent synaptic plasticity in a <i>N</i>‐methyl‐<scp>d</scp>‐aspartate receptor and phosphatidyl‐inositol‐3‐kinase‐dependent manner
Van Der Heide, L. P., Kamal, A., Artola, A., Gispen, W. H., & Ramakers, G. M. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03269.x · Cited by 278 · see citing works
Specific Roles of AMPA Receptor Subunit GluR1 (GluA1) Phosphorylation Sites in Regulating Synaptic Plasticity in the CA1 Region of Hippocampus
Lee, H.-K., Takamiya, K., He, K., Song, L., & Huganir, R. L. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00835.2009 · Cited by 261 · see citing works
Bidirectional synaptic plasticity: from theory to reality
Bear, M. F. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1255 · Cited by 260 · see citing works
Self-citation
Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome
Krueger, D. D., & Bear, M. F. (2011) · Annual Review of Medicine · doi:10.1146/annurev-med-061109-134644 · Cited by 259 · see citing works
Self-citation
Deep molecular diversity of mammalian synapses: why it matters and how to measure it
O'Rourke, N. A., Weiler, N. C., Micheva, K. D., & Smith, S. J. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3170 · Cited by 210 · see citing works
Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms
Gladding, C. M., Fitzjohn, S. M., & Molnár, E. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001735 · Cited by 233 · see citing works
Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze
Dong, Z., Bai, Y., Wu, X., Li, H., Gong, B., Howland, J. G., Huang, Y., He, W., Li, T., & Wang, Y. T. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.06.027 · Cited by 219 · see citing works
Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD
Regan, P., Piers, T., Yi, J.-H., Kim, D.-H., Huh, S., Park, S. J., Ryu, J. H., Whitcomb, D. J., & Cho, K. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.2842-14.2015 · Cited by 202 · see citing works
Chapter 6 Regulation of hippocampus-dependent memory by cyclic AMP-dependent protein kinase
Abel, T., & Nguyen, P. V. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(07)00006-4 · Cited by 198 · see citing works
Hippocampal Interneurons Express a Novel Form of Synaptic Plasticity
McMahon, L. L., & Kauer, J. A. (1997) · Neuron · doi:10.1016/s0896-6273(00)80269-x · Cited by 182 · see citing works
d-serine augments NMDA-NR2B receptor-dependent hippocampal long-term depression and spatial reversal learning
Duffy, S., Labrie, V., & Roder, J. C. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301486 · Cited by 173 · see citing works
Tyrosine phosphatases regulate AMPA receptor trafficking during metabotropic glutamate receptor-mediated long-term depression
Moult, P. R., Gladding, C. M., Sanderson, T. M., Fitzjohn, S. M., Bashir, Z. I., Molnar, E., & Collingridge, G. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4322-05.2006 · Cited by 172 · see citing works
Convergent Mechanisms Underlying Rapid Antidepressant Action
Zanos, P., Thompson, S. M., Duman, R. S., Zarate, C. A., & Gould, T. D. (2018) · CNS Drugs · doi:10.1007/s40263-018-0492-x · Cited by 171 · see citing works
Altered Stress-Induced Anxiety in Adenylyl Cyclase Type VIII-Deficient Mice
Schaefer, M. L., Wong, S. T., Wozniak, D. F., Muglia, L. M., Liauw, J. A., Zhuo, M., Nardi, A., Hartman, R. E., Vogt, S. K., Luedke, C. E., et al. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-13-04809.2000 · Cited by 152 · see citing works
Mechanisms Underlying the Rules for Associative Plasticity at Adult Human Neocortical Synapses
Verhoog, M. B., Goriounova, N. A., Obermayer, J., Stroeder, J., Hjorth, J. J. J., Testa-Silva, G., Baayen, J. C., de Kock, C. P. J., Meredith, R. M., & Mansvelder, H. D. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3158-13.2013 · Cited by 127 · see citing works
AKAP150-Anchored Calcineurin Regulates Synaptic Plasticity by Limiting Synaptic Incorporation of Ca<sup>2+</sup>-Permeable AMPA Receptors
Sanderson, J. L., Gorski, J. A., Gibson, E. S., Lam, P., Freund, R. K., Chick, W. S., & Dell'Acqua, M. L. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3326-12.2012 · Cited by 137 · see citing works
“…synapses in forebrain-restricted, conditional CaN knock-out mice and inhibition of LTD by CaN phosphatase inhibitors using a standard low-frequency stimulation (LFS) LTD induction protocol (900 pulses at 1 Hz) (Dudek and Bear, 1992; Mulkey and Malenka, 1992; Mulkey et al., 1994; Zeng et al., 2001).”
Method
Long-Term Potentiation in Distinct Subtypes of Hippocampal Nonpyramidal Neurons
Maccaferri, G., & McBain, C. J. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05334.1996 · Cited by 133 · see citing works
Autonomous CaMKII can promote either long-term potentiation or long-term depression, depending on the state of T305/T306 phosphorylation
Pi, H. J., Otmakhov, N., Lemelin, D., De Koninck, P., & Lisman, J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0133-10.2010 · Cited by 125 · see citing works
Synaptic memory and CaMKII
Nicoll, R. A., & Schulman, H. (2023) · Physiological Reviews · doi:10.1152/physrev.00034.2022 · Cited by 126 · see citing works
“Second, NMDAR-dependent long-term depression (LTD) depresses synaptic transmission and can reverse established LTP (374, 375) (see sect.”
Background
Persistence of Coordinated Long-Term Potentiation and Dendritic Spine Enlargement at Mature Hippocampal CA1 Synapses Requires N-Cadherin
Bozdagi, O., Wang, X.-B., Nikitczuk, J. S., Anderson, T. R., Bloss, E. B., Radice, G. L., Zhou, Q., Benson, D. L., & Huntley, G. W. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1223-10.2010 · Cited by 116 · see citing works
Rapid eye movement sleep deprivation modifies expression of long-term potentiation in visual cortex of immature rats.
Shaffery, J. P., Sinton, C. M., Bissette, G., Roffwarg, H. P., & Marks, G. A. (2002) · Neuroscience · doi:10.1016/s0306-4522(01)00589-9 · Cited by 114 · see citing works
Interactions between synaptic homeostatic mechanisms: An attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance
Keck, T., Hübener, M., & Bonhoeffer, T. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.003 · Cited by 93 · see citing works
Differential Effects of Excitatory and Inhibitory Plasticity on Synaptically Driven Neuronal Input-Output Functions
Carvalho, T. P., & Buonomano, D. V. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.013 · Cited by 100 · see citing works
Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus.
Christie, B. R., Eadie, B. D., Kannangara, T. S., Robillard, J. M., Shin, J., & Titterness, A. K. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8033-2 · Cited by 99 · see citing works
Long-Term Potentiation Induced by θ Frequency Stimulation Is Regulated by a Protein Phosphatase-1-Operated Gate
Brown, G. P., Blitzer, R. D., Connor, J. H., Wong, T., Shenolikar, S., Iyengar, R., & Landau, E. M. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-07880.2000 · Cited by 98 · see citing works
Neural ageing and synaptic plasticity: prioritizing brain health in healthy longevity
Navakkode, S., & Kennedy, B. K. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1428244 · Cited by 75 · see citing works
Developmental synaptic plasticity at the thalamocortical input to barrel cortex: Mechanisms and roles
Daw, M. I., Scott, H. L., & Isaac, J. T. R. (2007) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2007.01.001 · Cited by 70 · see citing works
Bayesian spiking neurons II: learning
Deneve, S. (2008) · Neural Computation · doi:10.1162/neco.2008.20.1.118 · Cited by 71 · see citing works
Synaptic modifications at the CA3–CA1 synapse after chronic AMPA receptor blockade in rat hippocampal slices
Mateos, J. M., Lüthi, A., Savic, N., Stierli, B., Streit, P., Gähwiler, B. H., & McKinney, R. A. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.120550 · Cited by 53 · see citing works
Insulin, Synaptic Function, and Opportunities for Neuroprotection
Mielke, J. G., & Wang, Y.-T. (2011) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-385506-0.00004-1 · Cited by 55 · see citing works
MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression
Nelson, P. A., Sage, J. R., Wood, S. C., Davenport, C. M., Anagnostaras, S. G., & Boulanger, L. M. (2013) · Learning & Memory · doi:10.1101/lm.031351.113 · Cited by 49 · see citing works
The contribution of ion channels in input-output plasticity
Debanne, D., & Russier, M. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107095 · Cited by 38 · see citing works
Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity
Ingram, R., Kang, H., Lightman, S., Jane, D. E., Bortolotto, Z. A., Collingridge, G. L., Lodge, D., & Volianskis, A. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.06.008 · Cited by 36 · see citing works
Camkii-Mediated Phosphorylation Regulates Distributions of Syngap-α1 and –α2 at the Postsynaptic Density
Yang, Y., Tao-Cheng, J.-H., Bayer, K. U., Reese, T. S., & Dosemeci, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071795 · Cited by 35 · see citing works
Faster perceptual learning through excitotoxic neurodegeneration
Beste, C., Wascher, E., Dinse, H. R., & Saft, C. (2012) · Current Biology · doi:10.1016/j.cub.2012.08.012 · Cited by 33 · see citing works
The postsubiculum and spatial learning: the role of postsubicular synaptic activity and synaptic plasticity in hippocampal place cell, object, and object-location memory
Bett, D., Stevenson, C. H., Shires, K. L., Smith, M. T., Martin, S. J., Dudchenko, P. A., & Wood, E. R. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.5476-12.2013 · Cited by 27 · see citing works
Effects of N- on quisqualate-stimulated phosphoinositide hydrolysis in slices of kitten striate cortex
Bohner, A. P., Dudek, S. M., & Bear, M. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)91040-l · Cited by 8 · see citing works
Self-citation

Independent mechanisms for long-term depression of AMPA and NMDA responses.
Selig, D. K., Hjelmstad, G., Herron, C., Nicoll, R., & Malenka, R. (1995) · Neuron · doi:10.1016/0896-6273(95)90045-4 · Cited by 137 · see citing works
Neurogranin and synaptic plasticity balance
Zhong, L., & Gerges, N. Z. (2010) · Communicative & Integrative Biology · doi:10.4161/cib.3.4.11763 · Cited by 33 · see citing works
Hippocampal CA1 synaptic plasticity as a gamma transfer function
Tamura, H., Ikegaya, Y., & Shiosaka, S. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.004 · Cited by 2 · see citing works
GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity
Duprat, F., Daw, M. I., Lim, W., Collingridge, G. L., & Isaac, J. T. R. (2004) · doi:10.1093/oso/9780198530305.003.0015 · Cited by 3 · see citing works
Bidirectional modulation of hippocampal synaptic plasticity by Dopaminergic D4-receptors in the CA1 area of hippocampus
Navakkode, S., Chew, K. C. M., Tay, S. J. N., Lin, Q., Behnisch, T., & Soong, T. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-15917-1 · Cited by 40 · see citing works

Authors: Dudek, S. M., & Bear, M. F.
Affiliations: Brown University (US)
ORCID: Dudek, S M
Bear, M F
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1992-05-15
Volume: 89
Issue: 10
Pages: 4363-4367
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.89.10.4363
PMC: PMC49082
OpenAlex: W2061405268
Cited by: 1,708
References: 25
Citations by year: 2026: 20 · 2025: 39 · 2024: 57 · 2023: 35 · 2022: 47 · 2021: 53 · 2020: 37 · 2019: 47 · 2018: 60 · 2017: 57 · 2016: 55 · 2015: 61 · 2014: 57 · 2013: 66 · 2012: 55
FWCI: 16.57
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Office of Naval Research
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: hippocampus, NMDA receptor antagonism, Schaffer collaterals, excitatory postsynaptic potentials, synaptic potentiation, stimulation frequency, long-term potentiation, synaptic plasticity, learning and memory
MeSH terms: Animals, Electric Stimulation, Evoked Potentials, Hippocampus, Male, Pyramidal Tracts, Rats, Inbred Strains, Cortical Spreading Depression, Synapses, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Homosynaptic long-term depression in area CA1 of hippocampus and effects of N-methyl-D-aspartate receptor blockade.

Abstract

Integrity signals

Claims the paper makes

Self-check

Cites

Cited by

Related

Record

About these checks