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Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

Aiba, A·1994·Cell

DOI 10.1016/0092-8674(94)90204-6

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Abstract

We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 (mGluR1). Gross anatomy of the hippocampus, excitatory synaptic transmission, long-term depression, and short-term potentiation in the hippocampal CA1 region are all apparently normal in the mutant mice. In contrast, long-term potentiation (LTP) is substantially reduced, and a moderate level of impairment is observed in context-specific associative learning. We propose that mGluR1 is not "in line" in LTP production, but rather modulates the plasticity process, and hence affects context-specific associative learning.

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Authors: Aiba, A.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Aiba, A
ORCID: Aiba, A
Venue: Cell
Publisher: Elsevier BV
Published: 1994-10-21
Volume: 79
Issue: 2
Pages: 365-375
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90204-6
OpenAlex: W1983956991
Cited by: 614
References: 49
Citations by year: 2026: 3 · 2025: 2 · 2024: 1 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 14 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 14 · 2015: 14 · 2014: 13 · 2013: 12 · 2012: 21
FWCI: 16.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01 NS32925, R01NS020591, NS20591, R01NS032925)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: metabotropic glutamate receptor 1, hippocampal long-term potentiation, hippocampal CA1, synaptic plasticity, long-term depression, short-term potentiation, excitatory synaptic transmission, learning disabilities
MeSH terms: Animals, Base Sequence, Electric Stimulation, Female, Genes, Hippocampus, Male, Mice, Inbred C57BL, Molecular Sequence Data, Synaptic Transmission, Neuronal Plasticity, Restriction Mapping, Receptors, Glutamate, Long-Term Potentiation, DNA Primers, Mice, Knockout, Mice, In Vitro Techniques

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Reduced hippocampal long-term potentiation and context-specific deficit in associative learning in mGluR1 mutant mice.

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