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The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

Hiramatsu, Ryuji, Akagi, Kiwamu, Matsuoka, Masao, Sakumi, Kunihiko, Nakamura, Hiro, Kingsbury, Linda, David, Chella, Hardy, Richard R., Yamamura, Ken-ichi, Sakano, Hitoshi·1995·Cell
DOI 10.1016/0092-8674(95)90138-8
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Abstract

Using transgenic substrates, we found that the immunoglobulin kappa gene 3' enhancer (E3') acts as a negative regulator in V kappa-J kappa joining. Although the E3' was originally identified as a transcriptional enhancer, it acts in a suppressive manner for recombinational regulation. Base substitution analysis has shown that the PU.1-binding site within the E3' regulates the B/T specificity of V kappa-J kappa joining. In a substrate with a mutated PU.1-binding site (GAGGAA to TCTTCG), V kappa-J kappa joining occurred not only in B cells, but also in T cells. The E3' region is also responsible for determining the pro-B/pre-B specificity of V kappa-J kappa joining. When the E3' region was deleted, kappa gene rearrangement actively occurred at the early pro-B stage of B cell development: nongermline (N) nucleotides were common at recombination junctions.

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Citations

Cites

Research works printed but not linked: 41

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Metadata

Authors
Hiramatsu, R., Akagi, K., Matsuoka, M., Sakumi, K., Nakamura, H., Kingsbury, L., David, C., Hardy, R. R., Yamamura, K.-I., & Sakano, H.
Venue
Cell
Publisher
Elsevier BV
Published
1995-12
Volume
83
Issue
7
Pages
1113-1123
ISSN
0092-8674
DOI
10.1016/0092-8674(95)90138-8
Cited by
45
References
5
Language
en
Licence
Funders
National Institutes of Health

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