The DOI matches its Crossref record; 54 of the 58 references it cites were found in a registry or an index.
TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1
Open accessAbstract
Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption. mec1-1 tel1 delta 1 double mutants are synergistically sensitive to DNA-damaging agents, including radiomimetic drugs. These data indicate that TEL1 and MEC1 are functionally related and that functions of the ATM gene are apparently divided between at least two S. cerevisiae homologs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“This separation of tasks is not found in budding yeast, where Mec1 (the ATR homologue) is the main player of checkpoint activation after all kind of DNA lesions, while Tel1 (the ATM homologue) is especially devoted to telomere maintenance. The redundant role of Tel1 in the DNA damage checkpoint is uncovered only in the absence of Mec1 [15,43].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [43]
Citations
Cites
Basic local alignment search tool
Altschul, S. F., Gish, W., Miller, W., Myers, E. W., & Lipman, D. J. (1990) · Journal of Molecular Biology · doi:10.1006/jmbi.1990.9999 · Cited by 98,669
Sikorski, R. S., & Hieter, P. (1989) · Genetics · doi:10.1093/genetics/122.1.19 · Cited by 8,590
Self-citationTransformation of intact yeast cells treated with alkali cations
Ito, H., Fukuda, Y., Murata, K., & Kimura, A. (1983) · Journal of Bacteriology · doi:10.1128/jb.153.1.163-168.1983 · Cited by 7,518
Sherman, F., Fink, G. R., & Hicks, J. B. (1979) · Cold Spring Harbor Laboratory eBooks · Cited by 7,430
Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
Kim, N. W., Piatyszek, M. A., Prowse, K. R., Harley, C. B., West, M. D., Ho, P. L. C., Coviello, G. M., Wright, W. E., Weinrich, S. L., & Shay, J. W. (1994) · Science · doi:10.1126/science.7605428 · Cited by 7,091
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Jacob, H. (1988) · Bioelectrochemistry and Bioenergetics · doi:10.1016/0302-4598(88)80052-7 · Cited by 4,911
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Self-citation
Cited by
Sorted by citations
Items 301–369 of 369
Dual roles of ATM in the cellular response to radiation and in cell growth control
(1997) · Trends in Genetics · doi:10.1016/s0168-9525(97)84642-2 · Cited by 6
Model Organisms Illuminate Human Genetics and Disease
van Heyningen, V. (1997) · Molecular Medicine · doi:10.1007/bf03401676 · Cited by 6
Identifying human homologs of cell cycle genes using dbEST and XREFdb
Bassett, D. E., Boguski, M. S., & Hieter, P. (1997) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(97)83012-1 · Cited by 6
Self-citationAll Things Must End: Telomere Dynamics in YeastPreprint
DuBois, M. L., Diede, S. J., Stellwagen, A. E., & Gottschling, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.281 · Cited by 6
Hayashi, N., Murakami, S., Tsurusaki, S., Nagaura, Z.-I., Oki, M., Nishitani, H., Kobayashi, M., Shimizu, H., Yamamoto, K.-I., & Nishimoto, T. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.12.028 · Cited by 5
Single Living yEast PM Toxicity Sensor (SLEPTor) System
Wei, K., Qiu, M., Zhang, R., Zhou, L., Zhang, T., Yao, M., & Luo, C. (2017) · Journal of Aerosol Science · doi:10.1016/j.jaerosci.2017.02.006 · Cited by 5
Novel Checkpoint Pathway Organization Promotes Genome Stability in Stationary-Phase Yeast Cells
Alver, B., Kelly, M. K., & Kirkpatrick, D. T. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05831-11 · Cited by 5
Forever hopeful relations: chromatin, telomeres and checkpoints
Weinert, T. A., & Lundblad, V. (1999) · Nature Genetics · doi:10.1038/5930 · Cited by 5
Park, S.-Y., Karatayeva, N., Demin, A. A., Munashingha, P. R., & Seo, Y. (2020) · FEBS Journal · doi:10.1111/febs.15475 · Cited by 3
Huang, D., Piening, B., Kennedy, J. J., Lin, C., Jones-Weinert, C. W., Yan, P., & Paulovich, A. G. (2016) · Genetics · doi:10.1534/genetics.115.185231 · Cited by 4
Souza, C. P. C. D., & Osmani, S. A. (2014) · ASM Press eBooks · doi:10.1128/9781555816636.ch6 · Cited by 4
Cao, J.-P., Meyn, M. S., Eckardt‐Schupp, F., & Fritz, E. (2001) · Radiation and Environmental Biophysics · doi:10.1007/s00411-001-0125-4 · Cited by 4
Koltovaya, N. A. (2009) · Russian Journal of Genetics · doi:10.1134/s1022795409010013 · Cited by 4
γH2A/γH2AX Mediates DNA Damage-Specific Control of Checkpoint Signaling in Saccharomyces cerevisiae
Siler, J., Guo, N., Liu, Z., Qin, Y., & Bi, X. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052462 · Cited by 3
Constantinou, M., Charidemou, E., Shanlitourk, I., Strati, K., & Kirmizis, A. (2024) · PLoS Genetics · doi:10.1371/journal.pgen.1011433 · Cited by 3
Systems Biomechanics of the Cell
Maly, I. V. (2013) · SpringerBriefs in bioengineering · doi:10.1007/978-1-4614-6883-7 · Cited by 3
Telomere Dynamics, Aging, and Cancer: Study of Human Syndromes Characteristic of Premature Aging
Multani, A. S., Narayan, S., Jaiswal, A. S., Zhao, Y.-J., Barkley, R. A., Furlong, C., & Pathak, S. (2002) · Rejuvenation Research · doi:10.1089/109454502321091473 · Cited by 3
Tibbetts, R. S., & Abraham, R. T. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-218-0_15 · Cited by 3
Digweed, M., & Fritz, E. (2003) · CRC Press eBooks · doi:10.1201/9780203911709.ch14 · Cited by 3
Checkpoint activation and recovery: regulation of the 9–1–1 axis by the PP2A phosphatase
Casari, E., Tisi, R., & Longhese, M. P. (2025) · DNA repair · doi:10.1016/j.dnarep.2025.103854 · Cited by 3
Prevention of DNA Rereplication Through a Meiotic Recombination Checkpoint Response
Najor, N. A., Weatherford, L., & Brush, G. S. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.033910 · Cited by 2
Checkpoint Controls Halting the Cell Cycle
Carr, A. M., & Caspari, T. (2004) · Springer eBooks · doi:10.1007/978-3-662-10360-9_4 · Cited by 2
Telomeres and Aging in the Yeast Model System
Runge, K. W. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50018-7 · Cited by 2
Fujimori, A., Hashimoto, H., Araki, R., Saito, T., Sato, S., Kasama, Y., Tsutsumi, Y., Mori, M., Fukumura, R., Ohhata, T., et al. (2002) · Radiation Research · doi:10.1667/0033-7587(2002)157[0298:saoako]2.0.co;2 · Cited by 2
Comparative Genomics: An Introduction: Sequencing Projects and Model Organisms
Clark, M. S. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4657-3_1 · Cited by 2
Kinase Cascade of DNA Damage Checkpoint
Koltovaya, N. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-48838-7_11 · Cited by 1
Rojas, J. M., López, R. M., & Guzmán, J. V. (2020) · Conexões · doi:10.20396/conex.v17i0.8654724 · Cited by 1
Recognition of DNA Damage as the Initial Step of Eukaryotic Checkpoint Arrest
Siede, W. (2005) · CRC Press eBooks · doi:10.1201/9780849352683.ch36 · Cited by 1
Biological basis of genetic predisposition to breast cancer
Dairkee, S. H., & Smith, H. S. (1999) · Advances in oncobiology/Advances in oncobiology (Print) · doi:10.1016/s1569-254x(98)80007-1 · Cited by 1
DNA damage checkpoint pathways and the maintenance of genome stability in C. elegans
Alpi, A. F. (2004) · Electronic Theses of LMU Munich (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.2448 · Cited by 1
Sibling rivalry, arrested development and chromosomal mayhem
Friend, S. H., & Tapscott, S. J. (1998) · Nature Genetics · doi:10.1038/ng0598-9 · Cited by 1
Heterochromatic DNA Double Strand Break Repair
Goodarzi, A. A., Noon, A. T., & Jeggo, P. A. (2009) · Institutional Repositories DataBase (IRDB) · doi:10.11343/amn.53.s13 · Cited by 1
Parker, J. A. (2009) · cIRcle (University of British Columbia) · doi:10.14288/1.0090415 · Cited by 1
Telomere Length Regulation by the Pif1 DNA Helicase
Monson, E. K., Schulz, V., & Zakian, V. A. (1997) · Springer eBooks · doi:10.1007/978-1-4615-5365-6_7 · Cited by 1
Maximizing Quantitative Phosphoproteomics of Kinase Signaling Expands the Mec1 and Tel1 NetworksPreprint
Faça, V. M., Sanford, E. J., Tieu, J., Marshall, S., Comstock, W. J., & Smolka, M. B. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.25.008367 · Cited by 1
Moore, D., & Frazer, L. N. (1996) · Mycological Research · doi:10.1016/s0953-7562(96)80151-1 · Cited by 1
Bennett, C. B. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00260-6
Free Histones and the Cell Cycle
Maya‐Miles, D., Morillo‐Huesca, M., Chávez, S., & Muñoz-Centeno, M. C. (2011) · InTech eBooks · doi:10.5772/22330
Hashash, N. (2009) · OpenGrey (Institut de l'Information Scientifique et Technique)
Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis
Spencer, F. A. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60505-5_3
Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability
Searle, J. S., & Sánchez, Y. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5963-6_2
Ataxia telangiectasia and signal transduction
Jung, M. (1996) · Radiation Oncology Investigations · doi:10.1002/(sici)1520-6823(1996)4:3
Principles of Cell Cycle Control
Norbury, C. J. (1997) · Comprehensive physiology · doi:10.1002/cphy.cp140121
REVIEW Cancer Risk and the ATM Gene: a Continuing Debate
Khanna, K. K. (2015)
Alver, B. (2012) · University of Minnesota Digital Conservancy (University of Minnesota)
Yeast Cells as a Discovery Platform for Parkinson's Disease and other Protein Misfolding Diseases
Allendoerfer, K. L., Su, L. J., & Lindquist, S. L. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374028-1.00038-5
Imai, T., Yamauchi, M., Seki, N., Sugawara, T., Sagara, M., Saito, T., Matsuda, Y., Itô, H., Nagase, T., Nomura, N., et al. (1998) · Springer eBooks · doi:10.1007/978-3-642-72082-6_14
Review Inositol pyrophosphates: metabolism and signaling
Bennett, M. C., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006)
Gabrielsen, P. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616437113
Dual roles of ATM in the cellular response to radiation and in cell growth control.Preprint
Xu, Y., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2401 · Cited by 407
Siler, J., Guo, N., Liu, Z., Qin, Y., & Bi, X. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/572271
Giulotto, E., & Mondello, C. (1998) · Advances in genome biology · doi:10.1016/s1067-5701(98)80004-1
(2014) · ASM Press eBooks · doi:10.1128/9781555816704.ch20
Gasser, S. M., & Shimada, K. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.733450126.793553437
Comparison of Two Budding Yeast Disome Model Systems: Similarities, Difference, and ConflictPreprint
Vinton, P. J., & Langston, R. E. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.11.519961
Exploring the Mechanisms of Telomerase Regulation in Saccharomyces cerevisiae
Fekete-Szücs, E. (2023) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.33612/diss.777966042
Principles of Cell Cycle Control
Norbury, C. J. (1996) · Comprehensive physiology · doi:10.1002/j.2040-4603.1996.tb01771.x
Role of the Asf1-Rad53 interaction in genomic stability in S.cerevisiae
Jiao, Y. (2011) · theses.fr (ABES) · doi:10.70675/6682a2b6z80c8z49e3z8704zd182d4f122f8
Molecular and Cellular Responses to the Shortest Telomere in Saccharomyces cerevisiae
Berardi, P. (2024) · theses.fr (ABES) · doi:10.70675/7b7d608bza43cz4696z9e55z6043326f7d64
Reflections on the early days of the DNA damage response pathway in eukaryotes
Elledge, S. J. (2026) · Genetics · doi:10.1093/genetics/iyag202
The mechanism of mitotic recombination in yeast
Lee, P. S. (2010) · DukeSpace (Duke University)
The rad201 Gene ofDrosophila melanogasterControls Mitotic Delay in Irradiated Cells
Khromykh, Y. M., & Kotlovanova, L. V. (2001) · Russian Journal of Genetics · doi:10.1023/a:1016693828849
Cloning human homologs of yeast genes
Seeley, T. W. (1999) · Elsevier eBooks · doi:10.1016/b978-012372185-3/50027-4
Metadata
- Authors
- Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P.
- Affiliations
- Johns Hopkins University (US)
- National Institutes of Health (US)
- Tel Aviv University (IL)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 82
- Issue
- 5
- Pages
- 831-840
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2028263332
- Cited by
- 370
- References
- 58
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 7
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- National Institute for Health and Care Research
- Ministerio de Economía y Competitividad
- National Institutes of Health
- National Cancer Institute (CA-16519, P01CA016519)
- National Institute of General Medical Sciences (GM162283)
- National Institute of Neurological Disorders and Stroke (R01NS031763, NS 31763)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Tel1, Mec1, ataxia telangiectasia, ATM gene, DNA damage checkpoint, radiomimetic drugs, dosage compensation, Saccharomyces cerevisiae
- MeSH terms
- Ataxia Telangiectasia, Base Sequence, Bleomycin, Cloning, Molecular, DNA Damage, Fungal Proteins, Gamma Rays, Genes, Fungal, Humans, Hydroxyurea, Molecular Sequence Data, Mutation, Phenotype, Saccharomyces cerevisiae, Streptonigrin, Ultraviolet Rays, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
