Cited by 370DNA Repair MechanismsFungal and yeast genetics researchBacterial Genetics and Biotechnology

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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

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Morrow, Dwight M, Tagle, Danilo A, Shiloh, Yosef, Collins, Francis S, Hieter, Philip·1995·Cell

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Abstract

Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption. mec1-1 tel1 delta 1 double mutants are synergistically sensitive to DNA-damaging agents, including radiomimetic drugs. These data indicate that TEL1 and MEC1 are functionally related and that functions of the ATM gene are apparently divided between at least two S. cerevisiae homologs.

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Authors: Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P.
Affiliations: Johns Hopkins University (US)
National Institutes of Health (US)
Tel Aviv University (IL)
ORCID: Tagle, Danilo A
Shiloh, Yosef
Collins, Francis S
Hieter, Philip
Venue: Cell
Publisher: Elsevier BV
Published: 1995-09
Volume: 82
Issue: 5
Pages: 831-840
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(95)90480-8
OpenAlex: W2028263332
Cited by: 370
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 7
FWCI: 14.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 3245 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: U.S. Department of Energy
National Institute for Health and Care Research
Ministerio de Economía y Competitividad
National Institutes of Health
National Cancer Institute (CA-16519, P01CA016519)
National Institute of General Medical Sciences (GM162283)
National Institute of Neurological Disorders and Stroke (R01NS031763, NS 31763)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Tel1, Mec1, ataxia telangiectasia, ATM gene, DNA damage checkpoint, radiomimetic drugs, dosage compensation, Saccharomyces cerevisiae
MeSH terms: Ataxia Telangiectasia, Base Sequence, Bleomycin, Cloning, Molecular, DNA Damage, Fungal Proteins, Gamma Rays, Genes, Fungal, Humans, Hydroxyurea, Molecular Sequence Data, Mutation, Phenotype, Saccharomyces cerevisiae, Streptonigrin, Ultraviolet Rays, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins

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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

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