Cited by 370DNA Repair MechanismsFungal and yeast genetics researchBacterial Genetics and Biotechnology

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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

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Morrow, Dwight M, Tagle, Danilo A, Shiloh, Yosef, Collins, Francis S, Hieter, Philip·1995·Cell

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Abstract

Patients with the genetic disorder ataxia telangiectasia (AT) have mutations in the AT mutated (ATM) gene, which is homologous to TEL1 and the checkpoint gene MEC1. A tel1 deletion mutant, unlike a mec1 deletion, is viable and does not exhibit increased sensitivity to DNA-damaging agents. However, increased dosage of TEL1 rescues sensitivity of a mec1 mutant, mec1-1, to DNA-damaging agents and rescues viability of a mec1 disruption. mec1-1 tel1 delta 1 double mutants are synergistically sensitive to DNA-damaging agents, including radiomimetic drugs. These data indicate that TEL1 and MEC1 are functionally related and that functions of the ATM gene are apparently divided between at least two S. cerevisiae homologs.

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Cancer Predisposition: Ataxia–telangiectasia at the crossroads
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Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae
Mallory, J. C., Bashkirov, V. I., Trujillo, K. M., Solinger, J. A., Dominska, M., Sung, P., Heyer, W., & Petes, T. D. (2003) · DNA repair · doi:10.1016/s1568-7864(03)00115-0 · Cited by 47
Telomere Loss in Somatic Cells of Drosophila Causes Cell Cycle Arrest and Apoptosis
Ahmad, K., & Golic, K. G. (1999) · Genetics · doi:10.1093/genetics/151.3.1041 · Cited by 46
Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms
McCulley, J. L., & Petes, T. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006281107 · Cited by 47
Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand breakPreprint
Anderson, C. M., Korkin, D., Smith, D. L., Makovets, S., Seidel, J. J., Šali, A., & Blackburn, E. H. (2008) · Genes & Development · doi:10.1101/gad.1646208 · Cited by 49
ATM-like kinases and regulation of telomerase: lessons from yeast and mammals
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The DNA damage checkpoint: A tale from budding yeast
Pizzul, P., Casari, E., Gnugnoli, M., Rinaldi, C., Corallo, F., & Longhese, M. P. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.995163 · Cited by 50
Characterization of a Saccharomyces cerevisiae homologue of Schizosaccharomyces pombe Chk1 involved in DNA-damage-induced M-phase arrest
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Mind the gap: keeping UV lesions in check
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“The redundant role of Tel1 in the DNA damage checkpoint is uncovered only in the absence of Mec1 [15,43].”
Background
Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression
Clerici, M., Paciotti, V., Baldo, V., Romano, M., Lucchini, G., & Longhese, M. P. (2001) · The EMBO Journal · doi:10.1093/emboj/20.22.6485 · Cited by 43
Meiotic roles of Mec1, a budding yeast homolog of mammalian ATR/ATM
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Cell Signalling by Inositol Pyrophosphates
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A Tel1/MRX-Dependent Checkpoint Inhibits the Metaphase-to-Anaphase Transition after UV Irradiation in the Absence of Mec1
Clerici, M., Baldo, V., Mantiero, D., Lottersberger, F., Lucchini, G., & Longhese, M. P. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.23.10126-10144.2004 · Cited by 41
Varying the number of telomere-bound proteins does not alter telomere length in tel1Δ cells
Ray, A., & Runge, K. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.15044 · Cited by 43

Authors: Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P.
Affiliations: Johns Hopkins University (US)
National Institutes of Health (US)
Tel Aviv University (IL)
ORCID: Tagle, Danilo A
Shiloh, Yosef
Collins, Francis S
Hieter, Philip
Venue: Cell
Publisher: Elsevier BV
Published: 1995-09
Volume: 82
Issue: 5
Pages: 831-840
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(95)90480-8
OpenAlex: W2028263332
Cited by: 370
References: 58
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 9 · 2015: 8 · 2014: 6 · 2013: 8 · 2012: 7
FWCI: 14.99
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 3245 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: U.S. Department of Energy
National Institute for Health and Care Research
Ministerio de Economía y Competitividad
National Institutes of Health
National Cancer Institute (CA-16519, P01CA016519)
National Institute of General Medical Sciences (GM162283)
National Institute of Neurological Disorders and Stroke (R01NS031763, NS 31763)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Tel1, Mec1, ataxia telangiectasia, ATM gene, DNA damage checkpoint, radiomimetic drugs, dosage compensation, Saccharomyces cerevisiae
MeSH terms: Ataxia Telangiectasia, Base Sequence, Bleomycin, Cloning, Molecular, DNA Damage, Fungal Proteins, Gamma Rays, Genes, Fungal, Humans, Hydroxyurea, Molecular Sequence Data, Mutation, Phenotype, Saccharomyces cerevisiae, Streptonigrin, Ultraviolet Rays, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Saccharomyces cerevisiae Proteins, Intracellular Signaling Peptides and Proteins

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TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

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