Shiloh, Yosef

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science

DNA Repair MechanismsProtein Kinase Regulation and GTPase Signaling

Cited by 3,075

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,785

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 2,577

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Banin, S., Moyal, L., Shieh, S.-Y., Taya, Y., Anderson, C. W., Chessa, L., Smorodinsky, N. I., Prives, C., Reiss, Y., Shiloh, Y., et al. (1998) · Science

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,797

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Shiloh, Y., & Ziv, Y. (2013) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 1,649

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 1,075

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

Goodarzi, A. A., Noon, A. T., Deckbar, D., Ziv, Y., Shiloh, Y., Löbrich, M., & Jeggo, P. A. (2008) · Molecular Cell

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 836

Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway

Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D. C., Lukas, J., Bekker-Jensen, S., Bartek, J., & Shiloh, Y. (2006) · Nature Cell Biology

DNA Repair MechanismsGenomics and Chromatin Dynamics

Cited by 735

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

Maya, R., Balass, M., Kim, S.-T., Shkedy, D., Leal, J.-F. M., Shifman, O., Moas, M., Buschmann, T., Ronai, Z., Shiloh, Y., et al. (2001) · Genes & Development

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 731

ATM and ATR: networking cellular responses to DNA damage

Shiloh, Y. (2001) · Current Opinion in Genetics & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 601

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

Khosravi, R., Maya, R., Gottlieb, T., Oren, M., Shiloh, Y., & Shkedy, D. (1999) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 461

TEL1, an S. cerevisiae homolog of the human gene mutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene, MEC1

Morrow, D. M., Tagle, D. A., Shiloh, Y., Collins, F. S., & Hieter, P. (1995) · Cell

DNA Repair MechanismsFungal and yeast genetics research

Cited by 370

New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., et al. (2022) · Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 319

ATM: Genome stability, neuronal development, and cancer cross paths

Shiloh, Y., & Kastan, M. B. (2001) · Advances in Cancer Research

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 299

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

Andegeko, Y., Moyal, L., Rotman, G., Shiloh, Y., Mittelman, L., & Tsarfaty, I. (2001) · Journal of Biological Chemistry

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 276

Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage

Pereg, Y., Shkedy, D., de Graaf, P., Meulmeester, E., Edelson-Averbukh, M., Salek, M., Biton, S., Teunisse, A. F. A. S., Lehmann, W. D., Jochemsen, A. G., et al. (2005) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 181

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

Rotman, G., & Shiloh, Y. (1997) · BioEssays

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 160

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK

Das, B. B., Antony, S., Gupta, S., Dexheimer, T. S., Redon, C. E., Garfield, S., Shiloh, Y., & Pommier, Y. (2009) · The EMBO Journal

DNA Repair MechanismsCancer therapeutics and mechanisms

Cited by 151

DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

Okamoto, K., Kashima, K., Pereg, Y., Ishida, M., Yamazaki, S., Nota, A., Teunisse, A., Migliorini, D., Kitabayashi, I., Marine, J.-C., et al. (2005) · Molecular and Cellular Biology

Cancer-related Molecular Pathways14-3-3 protein interactions

Cited by 129

Systemic DNA damage responses in aging and diseases

Ribezzo, F., Shiloh, Y., & Schumacher, B. (2016) · Seminars in Cancer Biology

DNA Repair MechanismsGenetics, Aging, and Longevity in Model Organisms

Cited by 116

Transcriptional modulation induced by ionizing radiation: p53 remains a central player

Rashi‐Elkeles, S., Elkon, R., Shavit, S., Lerenthal, Y., Linhart, C., Kupershtein, A., Amariglio, N., Rechavi, G., Shamir, R., & Shiloh, Y. (2011) · Molecular Oncology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 95

Differential Roles of ATM- and Chk2-Mediated Phosphorylations of Hdmx in Response to DNA Damage

Pereg, Y., Lam, S., Teunisse, A., Biton, S., Meulmeester, E., Mittelman, L., Buscemi, G., Okamoto, K., Taya, Y., Shiloh, Y., et al. (2006) · Molecular and Cellular Biology

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 93

Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by α-lipoic acid

Gatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F., & Rotman, G. (2001) · Oncogene

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 68