The DOI matches its Crossref record; 22 of the 23 references it cites were found in a registry or an index.
Cure of duodenal ulcer associated with eradication of Helicobacter pylori
Abstract
50 patients with intractable duodenal ulcer were randomly assigned to 4 weeks of treatment with colloidal bismuth subcitrate (CBS) alone (26 patients) or with amoxicillin and metronidazole (24 patients). 5 patients (all on triple therapy) withdrew because of side-effects. In 17 of the 45 patients who completed the treatment, Helicobacter pylori was eradicated, and there was no ulcer relapse during the first 12 months of follow-up. The ulcer relapse rate was significantly higher (17 of 21 [89%]) among patients who remained positive for H pylori. 9 patients who remained positive for H pylori and had ulcer relapses within 6 months of treatment with CBS alone, were subsequently given triple therapy. 7 of the 9 showed H pylori eradication and no relapses within the next 12 months. The 2 patients still H pylori-positive after triple therapy had further ulcer relapses. H pylori eradication, without altering acid output, will become the mainstay of duodenal ulcer treatment because it cures the disease.
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“A final piece of evidence was demonstration that antibiotics alone, without H2 blockers or PPIs, could cure ulcers [17–20].”
From What would it take to prove that a chronic infection is a causal agent in Alzheimer’s disease? (2025) · cites this paper as [20]
Citations
Cites
Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
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PROSPECTIVE DOUBLE-BLIND TRIAL OF DUODENAL ULCER RELAPSE AFTER ERADICATION OF CAMPYLOBACTER PYLORI
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Campylobacter pyloridis-associated chronic active antral gastritis
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Self-citationIngestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH.
Morris, A., & Nicholson, G. I. (1987) · PubMed · Cited by 750
CAMPYLOBACTER PYLORI AND RECURRENCE OF DUODENAL ULCERS— A 12-MONTH FOLLOW-UP STUDY
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CAMPYLOBACTER-UKE ORGANISMS IN THE STOMACH OF PATIENTS AND HEALTHY INDIVIDUALS
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Research works printed but not linked: 3
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Malfertheiner, P., Chan, F. K. L., & McColl, K. E. L. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60938-7 · Cited by 1,558
Malfertheiner, P., Camargo, M. C., El-Omar, E. M., Liou, J., Peek, R. M., Schulz, C., Smith, S. I., & Suerbaum, S. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00431-8 · Cited by 1,339
The Sydney System: Histological division
Price, A. B. (1991) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1991.tb01468.x · Cited by 991
Graham, D. Y., Lew, G. M., Klein, P. D., Evans, D. G., Evans, D. J., Saeed, Z. A., & Malaty, H. M. (1992) · Annals of Internal Medicine · doi:10.7326/0003-4819-116-9-705 · Cited by 909
Metadata
- Authors
- Rauws, E. A. J., & Tytgat, G. N. J.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Rauws, E.A.J.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1990-05
- Volume
- 335
- Issue
- 8700
- Pages
- 1233-1235
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2029865847
- Cited by
- 922
- References
- 23
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 6 · 2018: 6 · 2017: 12 · 2016: 13 · 2015: 10 · 2014: 18 · 2013: 11 · 2012: 14
- FWCI
- 106.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Keywords
- duodenal ulcer, Helicobacter pylori eradication, bismuth subcitrate, amoxicillin, metronidazole, triple therapy, ulcer recurrence
- MeSH terms
- Administration, Oral, Amoxicillin, Anti-Ulcer Agents, Campylobacter, Campylobacter Infections, Drug Administration Schedule, Drug Evaluation, Drug Therapy, Combination, Duodenal Ulcer, Follow-Up Studies, Gastric Mucosa, Humans, Metronidazole, Organometallic Compounds, Prospective Studies, Recurrence, Randomized Controlled Trials as Topic
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